Zobrazeno 1 - 10
of 95
pro vyhledávání: '"Lucy S K Walker"'
Autor:
Natalie M. Edner, Luke P. Houghton, Elisavet Ntavli, Chloe Rees-Spear, Lina Petersone, Chunjing Wang, Astrid Fabri, Yassin Elfaki, Andrea Rueda Gonzalez, Rachel Brown, Kai Kisand, Pärt Peterson, Laura E. McCoy, Lucy S. K. Walker
Publikováno v:
Frontiers in Immunology, Vol 15 (2024)
Circulating follicular helper T cells (cTfh) can show phenotypic alterations in disease settings, including in the context of tissue-damaging autoimmune or anti-viral responses. Using severe COVID-19 as a paradigm of immune dysregulation, we have exp
Externí odkaz:
https://doaj.org/article/e691596e5a1945598aa5b7e47fe61d36
Autor:
Chun Jing Wang, Lina Petersone, Natalie M. Edner, Frank Heuts, Vitalijs Ovcinnikovs, Elisavet Ntavli, Alexandros Kogimtzis, Astrid Fabri, Yassin Elfaki, Luke P. Houghton, Ralf J. Hosse, David A. Schubert, Andreas P. Frei, Ellen M. Ross, Lucy S. K. Walker
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-12 (2022)
Abstract Blockade of CD28 costimulation with CTLA-4-Ig/Abatacept is used to dampen effector T cell responses in autoimmune and transplantation settings. However, a significant drawback of this approach is impaired regulatory T cell homeostasis that r
Externí odkaz:
https://doaj.org/article/88fdb72320aa489eb09cc8536ed4b458
Autor:
Chun Jing Wang, Lina Petersone, Natalie M. Edner, Frank Heuts, Vitalijs Ovcinnikovs, Elisavet Ntavli, Alexandros Kogimtzis, Astrid Fabri, Yassin Elfaki, Luke P. Houghton, Ralf J. Hosse, David A. Schubert, Andreas P. Frei, Ellen M. Ross, Lucy S. K. Walker
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-1 (2023)
Externí odkaz:
https://doaj.org/article/bb4af0f8c0874ff3af8a19e29e105ca1
Publikováno v:
Frontiers in Immunology, Vol 11 (2021)
Externí odkaz:
https://doaj.org/article/8a8b15324867447e931725c3d88c6e08
Autor:
Neil Halliday, Cayman Williams, Alan Kennedy, Erin Waters, Anne M. Pesenacker, Blagoje Soskic, Claudia Hinze, Tie Zheng Hou, Behzad Rowshanravan, Daniel Janman, Lucy S. K. Walker, David M. Sansom
Publikováno v:
Frontiers in Immunology, Vol 11 (2020)
CD80 and CD86 are expressed on antigen presenting cells and are required to engage their shared receptor, CD28, for the costimulation of CD4 T cells. It is unclear why two stimulatory ligands with overlapping roles have evolved. CD80 and CD86 also bi
Externí odkaz:
https://doaj.org/article/4bb9b3851d544090be42099ef370e403
Autor:
Alexandra Mazharian, Blandine Maître, Alicia Bornert, Desline Hennequin, Marc Lourenco-Rodrigues, Mitchell J. Geer, Christopher W. Smith, Silke Heising, Michaela Walter, Florian Montel, Lucy S. K. Walker, Henri de la Salle, Steve P. Watson, Christian Gachet, Yotis A. Senis
Publikováno v:
Blood Advances. 7:46-59
Mice lacking the immunoreceptor tyrosine-based inhibition motif-containing co-inhibitory receptor G6b-B (Mpig6b, G6b knockout, KO) are born with a complex megakaryocyte (MK) per platelet phenotype, characterized by severe macrothrombocytopenia, expan
Publikováno v:
Nature Immunology. 23:1157-1168
Autor:
Natalie M Edner, Elisavet Ntavli, Lina Petersone, Chun Jing Wang, Astrid Fabri, Alexandros Kogimtzis, Vitalijs Ovcinnikovs, Ellen M Ross, Frank Heuts, Yassin Elfaki, Luke P Houghton, Toby Talbot, Amna Sheri, Alexandra Pender, David Chao, Lucy S K Walker
Publikováno v:
Immunotherapy Advances. 3
SummaryEfficacy of checkpoint inhibitor therapies in cancer varies greatly, with some patients showing complete responses while others do not respond and experience progressive disease. We aimed to identify correlates of response and progression foll
Autor:
Lina Petersone, Natalie M. Edner, Vitalijs Ovcinnikovs, Frank Heuts, Ellen M. Ross, Elisavet Ntavli, Chun J. Wang, Lucy S. K. Walker
Publikováno v:
Frontiers in Immunology, Vol 9 (2018)
Co-ordinated interaction between distinct cell types is a hallmark of successful immune function. A striking example of this is the carefully orchestrated cooperation between helper T cells and B cells that occurs during the initiation and fine-tunin
Externí odkaz:
https://doaj.org/article/a0edfa3c98b64d6e92fe1077110a0a54