Zobrazeno 1 - 10
of 347
pro vyhledávání: '"Lucy R Wedderburn"'
Autor:
Polly Livermore, Klaudia Kupiec, Lucy R Wedderburn, Andrea Knight, Ameenat L Solebo, Roz Shafran, Glenn Robert, N J Sebire, Faith Gibson
Publikováno v:
JMIR Research Protocols, Vol 13, p e57238 (2024)
BackgroundPediatric rheumatology is a term that encompasses over 80 conditions affecting different organs and systems. Children and young people with rheumatological chronic conditions are known to have high levels of mental health problems and there
Externí odkaz:
https://doaj.org/article/a5bddb5e1b874146875dd83a553aff6b
Autor:
Kathleen Mulligan, Shashivadan P Hirani, Sally Harris, Jo Taylor, Lucy R Wedderburn, Stanton Newman
Publikováno v:
Journal of Medical Internet Research, Vol 24, Iss 5, p e29787 (2022)
BackgroundJuvenile idiopathic arthritis (JIA) is a group of autoinflammatory diseases that cause pain and disability if not controlled by treatment. Parenting a child with JIA is stressful for parents, who express concerns about their child’s treat
Externí odkaz:
https://doaj.org/article/9522d7cb9dca465ea6f4902aadff70e5
Autor:
Ahmed F Hawwa, Abdelqader Albawab, Madeleine Rooney, Lucy R Wedderburn, Michael W Beresford, James C McElnay
Publikováno v:
PLoS ONE, Vol 9, Iss 2, p e89908 (2014)
Development and validation of a selective and sensitive LCMS method for the determination of methotrexate polyglutamates in dried blood spots (DBS).DBS samples [spiked or patient samples] were prepared by applying blood to Guthrie cards which was the
Externí odkaz:
https://doaj.org/article/09d4cc77bead45669e7a18b3ce2dfa0b
Autor:
Yvonne Vercoulen, Felicitas Bellutti Enders, Jenny Meerding, Maud Plantinga, Elisabeth F Elst, Hemlata Varsani, Christa van Schieveen, Mette H Bakker, Mark Klein, Rianne C Scholman, Wim Spliet, Valeria Ricotti, Hans J P M Koenen, Roel A de Weger, Lucy R Wedderburn, Annet van Royen-Kerkhof, Berent J Prakken
Publikováno v:
PLoS ONE, Vol 9, Iss 8, p e105353 (2014)
Juvenile dermatomyositis (JDM) is an immune-mediated inflammatory disease affecting the microvasculature of skin and muscle. CD4+ CD25+ FOXP3+ regulatory T cells (Tregs) are key regulators of immune homeostasis. A role for Tregs in JDM pathogenesis h
Externí odkaz:
https://doaj.org/article/3296525a23284cd694bfd5b6d58efaec
Association of the IL-10 gene family locus on chromosome 1 with juvenile idiopathic arthritis (JIA).
Autor:
Ebun Omoyinmi, Paola Forabosco, Raja Hamaoui, Annette Bryant, Anne Hinks, Simona Ursu, Childhood Arthritis Prospective Study (CAPS), BSPAR study group, Childhood Arthritis Response to Medication Study (CHARMS), Lucy R Wedderburn, Wendy Thomson, Cathryn M Lewis, Patricia Woo
Publikováno v:
PLoS ONE, Vol 7, Iss 10, p e47673 (2012)
BackgroundThe cytokine IL-10 and its family members have been implicated in autoimmune diseases and we have previously reported that genetic variants in IL-10 were associated with a rare group of diseases called juvenile idiopathic arthritis (JIA). T
Externí odkaz:
https://doaj.org/article/68848ac2dda2488597842d2648905178
Autor:
Jan D Haas, Kiran Nistala, Franziska Petermann, Namita Saran, Vijaykumar Chennupati, Susanne Schmitz, Thomas Korn, Lucy R Wedderburn, Reinhold Förster, Andreas Krueger, Immo Prinz
Publikováno v:
PLoS ONE, Vol 6, Iss 5, p e20171 (2011)
Differentiation of T helper 17 cells (Th17) is a multistep process that involves the cytokines IL-6, TGF-β, and IL-23 as well as IL-1β, IL-21, and TNF-α. Thereby, robust induction of the capacity to produce IL-17 involves epigenetic modifications
Externí odkaz:
https://doaj.org/article/bed165c268e341f991d0911b65c3c69d
Autor:
Lindsey A Edwards, Kiran Nistala, Dominic C Mills, Holly N Stephenson, Matthias Zilbauer, Brendan W Wren, Nick Dorrell, Keith J Lindley, Lucy R Wedderburn, Mona Bajaj-Elliott
Publikováno v:
PLoS ONE, Vol 5, Iss 11, p e15398 (2010)
BackgroundCampylobacter jejuni is the most prevalent cause of bacterial gastroenteritis worldwide. Despite the significant health burden this infection presents, molecular understanding of C. jejuni-mediated disease pathogenesis remains poorly define
Externí odkaz:
https://doaj.org/article/4c162ee640d244f0abc9b10af7c40bfd
Autor:
Charalampia Papadopoulou, Christine Chew, Meredyth G. Ll. Wilkinson, Liza McCann, Lucy R. Wedderburn
Publikováno v:
Nature Reviews Rheumatology. 19:343-362
Autor:
Meredyth G Ll Wilkinson, Dale Moulding, Thomas C R McDonnell, Michael Orford, Chris Wincup, Joanna Y J Ting, Georg W Otto, Restuadi Restuadi, Daniel Kelberman, Charalampia Papadopoulou, Sergi Castellano, Simon Eaton, Claire T Deakin, Elizabeth C Rosser, Lucy R Wedderburn
Publikováno v:
Annals of the Rheumatic Diseases. 82:658-669
ObjectivesTo define the host mechanisms contributing to the pathological interferon (IFN) type 1 signature in Juvenile dermatomyositis (JDM).MethodsRNA-sequencing was performed on CD4+, CD8+, CD14+and CD19+cells sorted from pretreatment and on-treatm
Publikováno v:
Clinical and Experimental Rheumatology. 40:394-403
Juvenile onset idiopathic inflammatory myopathy (IIM) has many similarities and distinct differences from adult-onset disease. This review will focus on recent developments in understanding and treatment of juvenile dermatomyositis (JDM), the most co