Výsledky vyhledávání

Akademický článek

Designing Clinical Trials for Anti-Inflammatory Therapies in Cystic Fibrosis

Autor: Lucy Perrem, Felix Ratjen

Publikováno v: Frontiers in Pharmacology, Vol 11 (2020)

The inflammatory response in the CF airway begins early in the disease process and becomes persistent through life in most patients. Inflammation, which is predominantly neutrophilic, worsens airway obstruction and plays a critical role in the develo

Externí odkaz: https://doaj.org/article/00d7c607950f4e1d9bc30e1e433e83e5

Zobrazit plný text záznamu

Lung Clearance Index to Track Acute Respiratory Events in School-Age Children with Cystic Fibrosis

Autor: Lucy Perrem, Sanja Stanojevic, Michelle Shaw, Renee Jensen, Nancy McDonald, Sarah M. Isaac, Miriam Davis, Charles Clem, Julia Guido, Sylvia Jara, Lisa France, Melinda Solomon, Hartmut Grasemann, Valerie Waters, Neil Sweezey, Don B. Sanders, Stephanie D. Davis, Felix Ratjen

Publikováno v: American Journal of Respiratory and Critical Care Medicine. 203:977-986

Rationale: The lung clearance index (LCI) is responsive to acute respiratory events in preschool children with cystic fibrosis (CF), but its utility to identify and manage these events in school-ag...

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::feb83962331ffaab6efe5b1684109c1a
https://doi.org/10.1164/rccm.202006-2433oc

Zobrazit plný text záznamu

Central catheter removal timing and growth patterns in preterm infants

Autor: A. Doolan, Lucy Perrem, Jan Miletin, Jana Semberova, Anne O’Sullivan, A. Branagan

Publikováno v: European Journal of Clinical Nutrition. 74:1661-1667

Early discontinuation of total parenteral nutrition (TPN) at 100 ml/kg/day of enteral feeds, compared with 140 ml/kg/day, led to significant delay in time to regain the birth weight in very low birth weight infants (birth weight

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::88b1a2dd7650888006fc5536b6112aaf
https://doi.org/10.1038/s41430-020-0645-0

Zobrazit plný text záznamu

Plný text ve formátu HTML

Changes in the parent cystic fibrosis questionnaire-revised (CFQ-R) with respiratory symptoms in preschool children with cystic fibrosis

Autor: Sanja Stanojevic, Stephanie D. Davis, Lucy Perrem, Felix Ratjen, Michelle Shaw, George Z. Retsch-Bogart

Publikováno v: J Cyst Fibros

Introduction The Cystic Fibrosis Questionnaire-Revised (CFQ-R) Respiratory score is a validated and widely used patient-reported outcome. This study aimed to establish changes in the score with acute respiratory events in preschool children with CF a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7bc3a8f0a06e650cce54083f6124af6a
https://doi.org/10.1016/j.jcf.2020.02.017

Zobrazit plný text záznamu

Comparative analysis of respiratory symptom scores to detect acute respiratory events in children with cystic fibrosis

Autor: Lucy Perrem, Sanja Stanojevic, Michelle Shaw, Maryjess Pornillos, Julia Guido, Don B. Sanders, Melinda Solomon, Hartmut Grasemann, Neil Sweezey, Valerie Waters, Stephanie D Davis, Felix Ratjen

Publikováno v: Journal of cystic fibrosis : official journal of the European Cystic Fibrosis Society.

Patient-reported outcomes (PROs) are important outcome measures in research and clinical practice. This study describes the longitudinal variability the Cystic Fibrosis Questionnaire-Revised (CFQ-R) Respiratory score and the Chronic Respiratory Infec

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eccefb1bfa22611aa98e013bba182144
https://pubmed.ncbi.nlm.nih.gov/35753986

Zobrazit plný text záznamu

Evaluation of clinically relevant changes in the lung clearance index in children with cystic fibrosis and healthy controls

Autor: Lucy Perrem, Sanja Stanojevic, Melinda Solomon, Hartmut Grasemann, Neil Sweezey, Valerie Waters, Don B Sanders, Stephanie D Davis, Felix Ratjen

Publikováno v: Thorax.

BackgroundThe limits of reproducibility of the lung clearance index (LCI) are higher in children with cystic fibrosis (CF) compared with healthy children, and it is currently unclear what defines a clinically meaningful change.MethodsIn a prospective

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::de1ddf02b6e0898831aa99c0bbc6c55c
https://pubmed.ncbi.nlm.nih.gov/35428702

Zobrazit plný text záznamu

Vyhledávací nástroje:

Upřesnit hledání