Zobrazeno 1 - 10
of 165
pro vyhledávání: '"Lucy M. Collinson"'
Autor:
Paul-Christian Burda, Abhinay Ramaprasad, Sabrina Bielfeld, Emma Pietsch, Anna Woitalla, Christoph Söhnchen, Mehar Nihal Singh, Jan Strauss, Aaron Sait, Lucy M. Collinson, Dominik Schwudke, Michael J. Blackman, Tim-Wolf Gilberger
Publikováno v:
mBio, Vol 14, Iss 4 (2023)
ABSTRACT For its replication within red blood cells, the malaria parasite depends on a highly active and regulated lipid metabolism. Enzymes involved in lipid metabolic processes such as phospholipases are, therefore, potential drug targets. Here, us
Externí odkaz:
https://doaj.org/article/c204e2746b334bc1a200c8924a7767df
Autor:
Anja C. Schlott, Ellen Knuepfer, Judith L. Green, Philip Hobson, Aaron J. Borg, Julia Morales-Sanfrutos, Abigail J. Perrin, Catherine Maclachlan, Lucy M. Collinson, Ambrosius P. Snijders, Edward W. Tate, Anthony A. Holder
Publikováno v:
PLoS Biology, Vol 19, Iss 10 (2021)
We have combined chemical biology and genetic modification approaches to investigate the importance of protein myristoylation in the human malaria parasite, Plasmodium falciparum. Parasite treatment during schizogony in the last 10 to 15 hours of the
Externí odkaz:
https://doaj.org/article/5fbf8e9a9f734a64b495f33819b59ac8
Autor:
Daniel Fisch, Barbara Clough, Marie-Charlotte Domart, Vesela Encheva, Hironori Bando, Ambrosius P. Snijders, Lucy M. Collinson, Masahiro Yamamoto, Avinash R. Shenoy, Eva-Maria Frickel
Publikováno v:
Cell Reports, Vol 32, Iss 6, Pp 108008- (2020)
Summary: Interferon-inducible guanylate-binding proteins (GBPs) promote cell-intrinsic defense through host cell death. GBPs target pathogens and pathogen-containing vacuoles and promote membrane disruption for release of microbial molecules that act
Externí odkaz:
https://doaj.org/article/fcd45fd07738483588df111dbf4ade5d
Autor:
Cefa Karabağ, Martin L. Jones, Christopher J. Peddie, Anne E. Weston, Lucy M. Collinson, Constantino Carlos Reyes-Aldasoro, Yuanquan Wang
Publikováno v:
PLoS ONE, Vol 15, Iss 10 (2020)
The quantitative study of cell morphology is of great importance as the structure and condition of cells and their structures can be related to conditions of health or disease. The first step towards that, is the accurate segmentation of cell structu
Externí odkaz:
https://doaj.org/article/ee24a1842df7407da96438028c2b0181
Autor:
Gary Hong Chun Chung, Marie-Charlotte Domart, Christopher Peddie, Judith Mantell, Kieran Mclaverty, Angela Arabiotorre, Lorna Hodgson, Richard D. Byrne, Paul Verkade, Kenton Arkill, Lucy M. Collinson, Banafshé Larijani
Publikováno v:
Journal of Lipid Research, Vol 59, Iss 8, Pp 1402-1413 (2018)
Dysregulation of nuclear envelope (NE) assembly results in various cancers; for example, renal and some lung carcinomas ensue due to NE malformation. The NE is a dynamic membrane compartment and its completion during mitosis is a highly regulated pro
Externí odkaz:
https://doaj.org/article/4427097e29ec42fd9b6672ab3da01cf7
Autor:
Charlotte E. Melia, Christopher J. Peddie, Anja W. M. de Jong, Eric J. Snijder, Lucy M. Collinson, Abraham J. Koster, Hilde M. van der Schaar, Frank J. M. van Kuppeveld, Montserrat Bárcena
Publikováno v:
mBio, Vol 10, Iss 3 (2019)
ABSTRACT Enterovirus genome replication occurs at virus-induced structures derived from cellular membranes and lipids. However, the origin of these replication organelles (ROs) remains uncertain. Ultrastructural evidence of the membrane donor is lack
Externí odkaz:
https://doaj.org/article/060c6b968b3649048287ffe1bae24e3f
Autor:
Yongchan Lee, Jens C. Hamann, Mark Pellegrino, Joanne Durgan, Marie-Charlotte Domart, Lucy M. Collinson, Cole M. Haynes, Oliver Florey, Michael Overholtzer
Publikováno v:
Cell Reports, Vol 26, Iss 12, Pp 3212-3220.e4 (2019)
Summary: Metazoan cell death mechanisms are diverse and include numerous non-apoptotic programs. One program called entosis involves the invasion of live cells into their neighbors and is known to occur in cancers. Here, we identify a developmental f
Externí odkaz:
https://doaj.org/article/471df9d5812b4a9bb524a4d4f4f846c0
Autor:
Abigail J. Perrin, Christine R. Collins, Matthew R. G. Russell, Lucy M. Collinson, David A. Baker, Michael J. Blackman
Publikováno v:
mBio, Vol 9, Iss 4 (2018)
ABSTRACT Apicomplexa are obligate intracellular parasites that actively invade, replicate within, and egress from host cells. The parasite actinomyosin-based molecular motor complex (often referred to as the glideosome) is considered an important med
Externí odkaz:
https://doaj.org/article/093ba9dc06054e14aab1802c0b6e0989
Autor:
Cefa Karabağ, Martin L. Jones, Christopher J. Peddie, Anne E. Weston, Lucy M. Collinson, Constantino Carlos Reyes-Aldasoro
Publikováno v:
Journal of Imaging, Vol 5, Iss 9, p 75 (2019)
This paper describes an unsupervised algorithm, which segments the nuclear envelope of HeLa cells imaged by Serial Block Face Scanning Electron Microscopy. The algorithm exploits the variations of pixel intensity in different cellular regions by calc
Externí odkaz:
https://doaj.org/article/cd6fbdc62c004131aa4cf3b83eccbcbb
Autor:
Elisabeth Brama, Christopher J. Peddie, Gary Wilkes, Yan Gu, Lucy M. Collinson, Martin L. Jones
Publikováno v:
Wellcome Open Research, Vol 1 (2016)
In-resin fluorescence (IRF) protocols preserve fluorescent proteins in resin-embedded cells and tissues for correlative light and electron microscopy, aiding interpretation of macromolecular function within the complex cellular landscape. Dual-contra
Externí odkaz:
https://doaj.org/article/75cb3a8a794a4ae2bd6bf04134e7cfbc