Zobrazeno 1 - 6
of 6
pro vyhledávání: '"Lucy M Kimbley"'
Autor:
Lucy M Kimbley, Rachel Parker, Jack Harrington, Robert C Walker, Ben Grace, Jonathan J West, Tim J Underwood, Matthew JJ Rose-Zerilli
Publikováno v:
BioTechniques, Vol 72, Iss 3, Pp 104-109 (2022)
Single-nuclei RNA sequencing allows single cell-based analysis in frozen tissue, ameliorating cell recovery biases associated with enzymatic dissociation methods. The authors present two optimized methods for isolating and sequencing nuclei from esop
Externí odkaz:
https://doaj.org/article/381a5d78a1c54facaec793d606d3523f
Autor:
Lucy M Kimbley, Rachel Parker, Maaike Sybil Jongen, John W Holloway, Emily J Swindle, Matthew JJ Rose-Zerilli
Publikováno v:
BioTechniques, Vol 71, Iss 1, Pp 387-391 (2021)
Single-cell RNA sequencing (scRNA-seq) of the bronchial epithelium enables examination of cellular subtypes and their responses to viral infections. Here, an optimized method for the isolation of virally infected primary bronchial epithelial cells us
Externí odkaz:
https://doaj.org/article/414344b6eb0145d0816cdde2bd71dad1
Autor:
Christopher J. Hanley, Sara Waise, Matthew J. Ellis, Maria A. Lopez, Wai Y. Pun, Julian Taylor, Rachel Parker, Lucy M. Kimbley, Serena J. Chee, Emily C. Shaw, Jonathan West, Aiman Alzetani, Edwin Woo, Christian H. Ottensmeier, Matthew J. J. Rose-Zerilli, Gareth J. Thomas
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-18 (2023)
Fibroblast heterogeneity is a prominent but poorly understood feature of solid tumours. Here three major fibroblast subpopulations in non-small cell lung cancer are identified and characterised through single cell RNA-sequencing, multiplexed immunohi
Externí odkaz:
https://doaj.org/article/90c9737e349b4a0f860180335c1700ab
Autor:
Maaike S. A. Jongen, Matthew Jj Rose-Zerilli, Lucy M Kimbley, John W. Holloway, Rachel Parker, Emily J. Swindle
Publikováno v:
BioTechniques. 71:387-391
Single-cell RNA sequencing (scRNA-seq) of the bronchial epithelium enables examination of cellular subtypes and their responses to viral infections. Here, an optimized method for the isolation of virally infected primary bronchial epithelial cells us
Autor:
Christian H. Ottensmeier, Julian Taylor, Jonathan West, Gareth J. Thomas, Christopher J. Hanley, Lucy M Kimbley, M Rose-Zerilli, Rachel Parker, Sara Waise, Maria-Antoinette Lopez
Fibroblasts are functionally heterogeneous cells, capable of promoting and suppressing tumour progression. Across cancer types, the extent and cause of this phenotypic diversity remains unknown. We used single-cell RNA sequencing and multiplexed immu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1a565c443f5be4a3eca43d7292a0d228
https://doi.org/10.1101/2020.06.08.134270
https://doi.org/10.1101/2020.06.08.134270
Autor:
Christian H. Ottensmeier, Julian Taylor, Jonathon West, M Rose-Zerilli, Maria-Antoinette Lopez, Gareth J. Thomas, Lucy M Kimbley, Sara Waise, Christopher J. Hanley, Parker Rachel
Publikováno v:
Cancer Research. 80:PO-039
In this study we set out to define the prominent fibroblast subpopulations found in human non-small cell lung cancer. Fibroblasts are functionally heterogeneous cells, capable of promoting and suppressing tumor progression. Across cancer types, the e