Zobrazeno 1 - 10
of 165
pro vyhledávání: '"Lucy M Collinson"'
Autor:
Anja C Schlott, Ellen Knuepfer, Judith L Green, Philip Hobson, Aaron J Borg, Julia Morales-Sanfrutos, Abigail J Perrin, Catherine Maclachlan, Lucy M Collinson, Ambrosius P Snijders, Edward W Tate, Anthony A Holder
Publikováno v:
PLoS Biology, Vol 19, Iss 10, p e3001408 (2021)
We have combined chemical biology and genetic modification approaches to investigate the importance of protein myristoylation in the human malaria parasite, Plasmodium falciparum. Parasite treatment during schizogony in the last 10 to 15 hours of the
Externí odkaz:
https://doaj.org/article/34e864e4f85047e9879d4fa62f5010e1
Autor:
Christine R Collins, Fiona Hackett, Steven A Howell, Ambrosius P Snijders, Matthew RG Russell, Lucy M Collinson, Michael J Blackman
Publikováno v:
eLife, Vol 9 (2020)
Red blood cell (RBC) invasion by malaria merozoites involves formation of a parasitophorous vacuole into which the parasite moves. The vacuole membrane seals and pinches off behind the parasite through an unknown mechanism, enclosing the parasite wit
Externí odkaz:
https://doaj.org/article/db80ffd4e5224938a70dac40b370a90c
Autor:
Cefa Karabağ, Martin L Jones, Christopher J Peddie, Anne E Weston, Lucy M Collinson, Constantino Carlos Reyes-Aldasoro
Publikováno v:
PLoS ONE, Vol 15, Iss 10, p e0230605 (2020)
The quantitative study of cell morphology is of great importance as the structure and condition of cells and their structures can be related to conditions of health or disease. The first step towards that, is the accurate segmentation of cell structu
Externí odkaz:
https://doaj.org/article/174a34d3ecd647db8fc7dbc9ca0a2222
Autor:
Emma S Sherling, Abigail J Perrin, Ellen Knuepfer, Matthew R G Russell, Lucy M Collinson, Louis H Miller, Michael J Blackman
Publikováno v:
PLoS Pathogens, Vol 15, Iss 9, p e1008049 (2019)
The malaria parasite Plasmodium falciparum invades, replicates within and destroys red blood cells in an asexual blood stage life cycle that is responsible for clinical disease and crucial for parasite propagation. Invasive malaria merozoites possess
Externí odkaz:
https://doaj.org/article/2489d6a65cf34f7da3cb255cdebd8f41
Autor:
Marie-Charlotte Domart, Tina M C Hobday, Christopher J Peddie, Gary H C Chung, Alan Wang, Karen Yeh, Nirmal Jethwa, Qifeng Zhang, Michael J O Wakelam, Rudiger Woscholski, Richard D Byrne, Lucy M Collinson, Dominic L Poccia, Banafshé Larijani
Publikováno v:
PLoS ONE, Vol 7, Iss 12, p e51150 (2012)
The functions and morphology of cellular membranes are intimately related and depend not only on their protein content but also on the repertoire of lipids that comprise them. In the absence of in vivo data on lipid asymmetry in endomembranes, it has
Externí odkaz:
https://doaj.org/article/740a89a7ae874dad8993050362785356
Imaging transient blood vessel fusion events in zebrafish by correlative volume electron microscopy.
Autor:
Hannah E J Armer, Giovanni Mariggi, Ken M Y Png, Christel Genoud, Alexander G Monteith, Andrew J Bushby, Holger Gerhardt, Lucy M Collinson
Publikováno v:
PLoS ONE, Vol 4, Iss 11, p e7716 (2009)
The study of biological processes has become increasingly reliant on obtaining high-resolution spatial and temporal data through imaging techniques. As researchers demand molecular resolution of cellular events in the context of whole organisms, corr
Externí odkaz:
https://doaj.org/article/08ac156c91e84c0cb0a824e53c36e166
Autor:
Paul-Christian Burda, Abhinay Ramaprasad, Sabrina Bielfeld, Emma Pietsch, Anna Woitalla, Christoph Söhnchen, Mehar Nihal Singh, Jan Strauss, Aaron Sait, Lucy M. Collinson, Dominik Schwudke, Michael J. Blackman, Tim-Wolf Gilberger
Publikováno v:
mBio, Vol 14, Iss 4 (2023)
ABSTRACT For its replication within red blood cells, the malaria parasite depends on a highly active and regulated lipid metabolism. Enzymes involved in lipid metabolic processes such as phospholipases are, therefore, potential drug targets. Here, us
Externí odkaz:
https://doaj.org/article/c204e2746b334bc1a200c8924a7767df
Autor:
Jane C. Stinchcombe, Yukako Asano, Christopher J. G. Kaufman, Kristin Böhlig, Christopher J. Peddie, Lucy M. Collinson, André Nadler, Gillian M. Griffiths
Publikováno v:
Science. 380:818-823
Cytotoxic T lymphocytes (CTLs) kill virus-infected and cancer cells through T cell receptor (TCR) recognition. How CTLs terminate signaling and disengage to allow serial killing has remained a mystery. TCR activation triggers membrane specialization
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f603013f7c79fc3c32582a318a2827c5
https://doi.org/10.1126/science.abp8933
https://doi.org/10.1126/science.abp8933
Autor:
Daniel Krentzel, Matouš Elphick, Marie-Charlotte Domart, Christopher J. Peddie, Romain F. Laine, Ricardo Henriques, Lucy M. Collinson, Martin L. Jones
Correlative light and volume electron microscopy (vCLEM) is a powerful imaging technique that enables visualisation of fluorescently labelled proteins within their ultrastructural context on a subcellular level. Currently, expert microscopists find t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8c05b56c493780180fe905f5d2f51719
https://doi.org/10.1101/2023.05.11.540445
https://doi.org/10.1101/2023.05.11.540445
Autor:
Lucy M. Collinson, Carles Bosch, Anwen Bullen, Jemima J. Burden, Raffaella Carzaniga, Cheng Cheng, Michele C. Darrow, Georgina Fletcher, Errin Johnson, Kedar Narayan, Christopher J. Peddie, Martyn Winn, Charles Wood, Ardan Patwardhan, Gerard J. Kleywegt, Paul Verkade
Publikováno v:
Collinson, L M, Bosch, C, Bullen, A, Burden, J J, Carzaniga, R, Cheng, C, Darrow, M C, Fletcher, G, Johnson, E, Narayan, K, Peddie, C J, Winn, M, Wood, C, Patwardhan, A, Kleywegt, G J & Verkade, P 2023, ' Volume EM : a quiet revolution takes shape ', Nature Methods, vol. 20, no. 6, pp. 777-782 . https://doi.org/10.1038/s41592-023-01861-8
Volume electron microscopy (vEM) is a group of techniques that reveal the 3D ultrastructure of cells and tissues through continuous depths of at least 1 micrometer. A burgeoning grassroots community effort is fast building the profile and revealing t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9d3913f95f04543d2a13dd1040ccd538
https://doi.org/10.1038/s41592-023-01861-8
https://doi.org/10.1038/s41592-023-01861-8