Zobrazeno 1 - 10
of 14
pro vyhledávání: '"Lucy Kirkham-McCarthy"'
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-12 (2024)
Abstract Dissemination of multiple myeloma into the bone marrow proceeds through sequential steps mediated by a variety of adhesion molecules and chemokines that eventually results in the extravasation of malignant plasma cells into this protective n
Externí odkaz:
https://doaj.org/article/0027f159d20e4443a71312c37e812095
Autor:
Mark Gurney, Arwen Stikvoort, Emma Nolan, Lucy Kirkham-McCarthy, Stanislav Khoruzhenko, Rama Shivakumar, Sonja Zweegman, Niels W.C.J. van de Donk, Tuna Mutis, Eva Szegezdi, Subhashis Sarkar, Michael O’Dwyer
Publikováno v:
Haematologica, Vol 107, Iss 2 (2020)
There is a strong biological rationale for the augmentation of allogeneic natural killer (NK) cell therapies with a chimeric antigen receptor (CAR) to enhance acute myeloid leukemia (AML) targeting. CD38 is an established immunotherapeutic target in
Externí odkaz:
https://doaj.org/article/b0166d6551d14cd29eee673fac8c0c91
Autor:
Alessandro Natoni, Mariah L. Farrell, Sophie Harris, Carolyne Falank, Lucy Kirkham-McCarthy, Matthew S. Macauley, Michaela R. Reagan, Michael O’Dwyer
Publikováno v:
Haematologica, Vol 105, Iss 2 (2020)
Aberrant glycosylation resulting from altered expression of sialyltransferases, such as ST3 β-galactoside α2-3-sialyltransferase 6, plays an important role in disease progression in multiple myeloma (MM). Hypersialylation can lead to increased immu
Externí odkaz:
https://doaj.org/article/0ad5f9da28a14ec79b3a3aae64f07875
Publikováno v:
Scientific Reports, Vol 7, Iss 1, Pp 1-15 (2017)
Abstract Huntington’s disease (HD) is a neurodegenerative disorder whose major symptoms include progressive motor and cognitive dysfunction. Cognitive decline is a critical quality of life concern for HD patients and families. The enzyme histone de
Externí odkaz:
https://doaj.org/article/83fb75d6d54c4e1bb96e9a37f243acff
Autor:
Kim Debacker, Aisling Frizzell, Olive Gleeson, Lucy Kirkham-McCarthy, Tony Mertz, Robert S Lahue
Publikováno v:
PLoS Biology, Vol 10, Iss 2, p e1001257 (2012)
Expansions of DNA trinucleotide repeats cause at least 17 inherited neurodegenerative diseases, such as Huntington's disease. Expansions can occur at frequencies approaching 100% in affected families and in transgenic mice, suggesting that specific c
Externí odkaz:
https://doaj.org/article/b927da874127465b9d9a9362fd86d0c4
Autor:
Alessandro Natoni, Marina Cerreto, Maria Stefania De Propris, Maria Teresa Petrucci, Francesca Fazio, Stefania Intoppa, Maria Laura Milani, Lucy Kirkham-McCarthy, Robert Henderson, Dawn Swan, Anna Guarini, Michael O’Dwyer, Robin Foà
Publikováno v:
Cancers; Volume 15; Issue 7; Pages: 2154
Multiple myeloma (MM) is a plasma cell disorder that develops in the bone marrow (BM) and is characterized by uncontrolled proliferation and the ability to disseminate to different sites of the skeleton. Sialofucosylated structures, particularly Sial
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f6174af36b573f5c3054f0b65e6b4724
Autor:
Sophie Harris, Alessandro Natoni, Matthew S. Macauley, Mariah Farrell, Michael O'Dwyer, Carolyne Falank, Michaela R. Reagan, Lucy Kirkham-McCarthy
Publikováno v:
Haematologica
Aberrant glycosylation resulting from altered expression of sialyltransferases, such as ST3 β-galactoside α2-3-sialyltransferase 6, plays an important role in disease progression in multiple myeloma (MM). Hypersialylation can lead to increased immu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8a613ef8c3f560563d44081f42cb4271
http://europepmc.org/articles/PMC7012485
http://europepmc.org/articles/PMC7012485
Autor:
Michael O’Dwyer, Enda Shevlin, Sarah Brophy, David Hermanson, Hallie Hintz, Neil Otto, Brianna Ettestad, Lucy Kirkham-McCarthy, Marjut Köylijärvi, David Hardwicke, Mary Reilly
Publikováno v:
Clinical Lymphoma Myeloma and Leukemia. 22:S45-S46
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::00b2c6cb0e4f5a3d180b98fc02544a5a
https://doi.org/10.1016/s2152-2650(22)00348-2
https://doi.org/10.1016/s2152-2650(22)00348-2
Autor:
Shaji Kumar, Elena Ellert, M. Andrulis, C. Connolly, W. E. Fogler, Lucy Kirkham-McCarthy, S. C. Locatelli-Hoops, Alessandro Natoni, Cian McEllistrim, I. Oliva, Niamh Keane, T. A.G. Smith, Michael O'Dwyer, Marc-Steffen Raab, Alokkumar Jha, Siobhan Glavey, John L. Magnani
Publikováno v:
Leukemia
Multiple myeloma (MM) is characterized by the clonal expansion and metastatic spread of malignant plasma cells to multiple sites in the bone marrow (BM). Recently, we implicated the sialyltransferase ST3Gal-6, an enzyme critical to the generation of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5938687e89786dec6f36f16977415c5c
http://europepmc.org/articles/PMC5729350
http://europepmc.org/articles/PMC5729350
Autor:
Mariah Farrell, Heather Fairfield, Lucy Kirkham-McCarthy, Alessandro Natoni, Michaela R. Reagan, Michael O'Dwyer, Matt Macauley
Introduction Multiple myeloma (MM) is a cancer of clonal plasma cells that hijack the bone marrow (BM) niche to create a drug resistant, incurable malignancy. Aberrant sialylation has been linked to immune cell evasion, drug resistance, and metastasi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4c74104fc90f478e66eb2a14c14e4e21
https://hdl.handle.net/11573/1673727
https://hdl.handle.net/11573/1673727
