Inhibitory effects of fluorinated benzenesulfonamides on insulin fibrillation

Autor: Saeid Hadi Ali Janvand, Lucy Kate Ladefoged, Asta Zubrienė, Andrius Sakalauskas, Gunna Christiansen, Virginija Dudutienė, Birgit Schiøtt, Daumantas Matulis, Vytautas Smirnovas, Daniel E. Otzen

Publikováno v: Alijanvand, S H, Ladefoged, L K, Zubrienė, A, Sakalauskas, A, Christiansen, G, Dudutiene, V, Schiøtt, B, Matulis, D, Smirnovas, V & Otzen, D E 2023, ' Inhibitory effects of fluorinated benzenesulfonamides on insulin fibrillation ', International Journal of Biological Macromolecules, vol. 227, pp. 590-600 . https://doi.org/10.1016/j.ijbiomac.2022.12.105
International journal of biological macromolecules, Amsterdam : Elsevier, 2023, vol. 227, p. 590-600

Amyloid fibrils are protein aggregates formed by protein assembly through cross β structures. Inhibition of amyloid fibril formation may contribute to therapy against amyloid-related disorders like Parkinson's, Alzheimer's, and type 2 diabetes. Here

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::12638c84d7aa0709214d3cfcfb56f56e
https://vbn.aau.dk/ws/files/531241107/1_s2.0_S0141813022030070_main.pdf

Potentiation of Drug Toxicity through Virus Latency Reversal Promotes Preferential Elimination of HIV Infected Cells

Autor: Thanh Tung Truong, Manuel Hayn, Camilla Kaas Frich, Lia‐Raluca Olari, Lucy Kate Ladefoged, Morten T. Jarlstad Olesen, Josefine H. Jakobsen, Cherie K. Lunabjerg‐Vestergaard, Birgit Schiøtt, Jan Münch, Alexander N. Zelikin

Publikováno v: Truong, T T, Hayn, M, Frich, C K, Olari, L-R, Ladefoged, L K, Olesen, M T J, Jakobsen, J H, Lunabjerg-Vestergaard, C K, Schiøtt, B, Münch, J & Zelikin, A N 2022, ' Potentiation of Drug Toxicity through Virus Latency Reversal Promotes Preferential Elimination of HIV Infected Cells ', Advanced Therapeutics, vol. 5, no. 11, 2200113 . https://doi.org/10.1002/adtp.202200113

Eliminating latently infected cells is a highly challenging, indispensable step toward the cure for HIV/AIDS. Hypothesis put forward herein is that the unique HIV protease cut site (Phe-Pro) can be reconstructed using a potent inhibitor of tubulin po

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f33d4b88f7b4ffe160418a863e4ff46a
https://pure.au.dk/portal/da/publications/potentiation-of-drug-toxicity-through-virus-latency-reversal-promotes-preferential-elimination-of-hiv-infected-cells(323f54da-3321-4e75-890f-728061c7bbe7).html

Monoamine transporters: Insights from molecular dynamics simulations

Autor: Julie eGrouleff, Lucy Kate Ladefoged, Heidi eKoldsø, Birgit eSchiøtt

Publikováno v: Frontiers in Pharmacology, Vol 6 (2015)

The human monoamine transporters facilitate the reuptake of the neurotransmitters serotonin, dopamine, and norepinephrine from the synaptic cleft. Imbalance in monoaminergic neurotransmission is linked to various diseases including major depression,

Externí odkaz: https://doaj.org/article/de777b266fd74b19808e3d286867ea92

Molecular modeling of neurological membrane proteins − from binding sites to synapses

Autor: Talia Zeppelin, Lucy Kate Ladefoged, Birgit Schiøtt

Publikováno v: Ladefoged, L K, Zeppelin, T & Schiøtt, B 2019, ' Molecular modeling of neurological membrane proteins − from binding sites to synapses ', Neuroscience Letters, vol. 700, pp. 38-49 . https://doi.org/10.1016/j.neulet.2018.05.034

The field of molecular mechanics studies of proteins has developed enormously since its origin in the 1970’s, and many applications and methodologies have branched from the original idea of the force field. The applications of such methodologies ar

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f5bda57502c630bcfa46b053ed0dc85a
https://doi.org/10.1016/j.neulet.2018.05.034

Beneficent and maleficent effects of cations on bufadienolide binding to Na+,K+-ATPase

Autor: Lucy Kate Ladefoged, Natalya U. Fedosova, Birgit Schiøtt

Publikováno v: Ladefoged, L K, Schiøtt, B & Fedosova, N U 2021, ' Beneficent and Maleficent Effects of Cations on Bufadienolide Binding to Na +,K +-ATPase ', Journal of Chemical Information and Modeling, vol. 61, no. 2, pp. 976-986 . https://doi.org/10.1021/acs.jcim.0c01396
Ladefoged, L K, Schiøtt, B & Fedosova, N 2021, ' Beneficent and Maleficent Effects of Cations on Bufadienolide Binding to Na+,K+-ATPase ', Journal of Chemical Information and Modeling, vol. 61, no. 2, pp. 976-986 . https://doi.org/10.1021/acs.jcim.0c01396

Kinetic properties and crystal structures of the Na+,K+-ATPase in complex with cardiotonic steroids (CTS) revealed significant differences between CTS subfamilies (Laursen et al., 2015): beneficial effects of K+ on bufadienolide binding strongly cont

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::29bea1585f4c8b91746be6535a67a981
https://doi.org/10.1101/2020.11.09.373902