Zobrazeno 1 - 8
of 8
pro vyhledávání: '"Lucy J. Martinez-Guerrero"'
Publikováno v:
J Pharmacol Exp Ther
In the wake of the COVID-19 pandemic, drug repurposing has been highlighted for rapid introduction of therapeutics. Proposed drugs with activity against SARS-CoV-2 include compounds with positive charges at physiologic pH, making them potential targe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4c853a437651c9617a690f5c752fc272
https://doi.org/10.1124/jpet.121.000619
https://doi.org/10.1124/jpet.121.000619
Publikováno v:
American Journal of Physiology-Renal Physiology. 310:F57-F67
Secretion of organic cations (OCs) across renal proximal tubules (RPTs) involves basolateral OC transporter (OCT)2-mediated uptake from the blood followed by apical multidrug and toxin extruder (MATE)1/2-mediated efflux into the tubule filtrate. Wher
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5ca1b27c09f56306d386805b232a1e5b
https://doi.org/10.1152/ajprenal.00318.2015
https://doi.org/10.1152/ajprenal.00318.2015
Publikováno v:
The FASEB Journal. 34:1-1
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3b1c049b4ed0b8b4cb3c17c26f06a7f9
https://doi.org/10.1096/fasebj.2020.34.s1.09069
https://doi.org/10.1096/fasebj.2020.34.s1.09069
Publikováno v:
Journal of Pharmacology and Experimental Therapeutics. 346:495-503
The multidrug and toxin extruders 1- and 2-K (MATE1 and MATE2-K) are expressed in the luminal membrane of renal proximal tubule cells and provide the active step in the secretion of molecules that carry a net positive charge at physiologic pH, so-cal
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::788e00f5326176557f3e5f153e437d1a
https://doi.org/10.1124/jpet.113.204206
https://doi.org/10.1124/jpet.113.204206
Multidrug and toxin extruder (MATE) 1 plays a central role in mediating renal secretion of organic cations, a structurally diverse collection of compounds that includes ∼40% of prescribed drugs. Because inhibition of transport activity of other mul
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d66a2e38827f1570b0ea6a11ea991ff5
https://europepmc.org/articles/PMC4998666/
https://europepmc.org/articles/PMC4998666/
Autor:
Yaofeng Cheng, I. Glenn Sipes, Lucy J. Martinez-Guerrero, R. K. Kuester, Stephen H. Wright, Michelle J. Hooth
Publikováno v:
Drug Metabolism and Disposition. 39:1755-1761
Ionic liquids (ILs) are a class of salts that are expected to be used as a new source of solvents and for many other applications. Our previous studies revealed that selected ILs, structurally related organic cations, are eliminated exclusively in ur
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fc5b35b6d881bfa8d7f7856fcb6dfd20
https://doi.org/10.1124/dmd.110.035865
https://doi.org/10.1124/dmd.110.035865
Autor:
Lucy J. Martinez-Guerrero, Takahiro Shibayama, Xiaohong Zhang, Mark Morales, Timothy W. Secomb, Alfred Berteloot, Stephen H. Wright
Unstirred water layers (UWLs) present an unavoidable complication to the measurement of transport kinetics in cultured cells, and the high rates of transport achieved by overexpressing heterologous transporters exacerbate the UWL effect. This study e
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9301c0e2ca47a5edbfe6075679b7b0a1
https://europepmc.org/articles/PMC4529401/
https://europepmc.org/articles/PMC4529401/
Publikováno v:
The FASEB Journal. 26
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ad9f02ec1fc9118a3e98d2fb588ed7dc
https://doi.org/10.1096/fasebj.26.1_supplement.1099.4
https://doi.org/10.1096/fasebj.26.1_supplement.1099.4