Zobrazeno 1 - 10
of 22
pro vyhledávání: '"Lucy J Goudswaard"'
Autor:
Naveed Sattar, Kaitlin H Wade, Dimitri J Pournaras, Nicholas J Timpson, Madeleine L Smith, Lucy J Goudswaard, Laura J Corbin
Publikováno v:
BMJ Medicine, Vol 3, Iss 1 (2024)
Associations between obesity and health are unequivocal and coupled with a substantial body of evidence suggesting that associations are likely causal. These associations and the supporting causal evidence are useful, but hide both the inadequacies o
Externí odkaz:
https://doaj.org/article/545b6bc4f080412296f2f3e270f12e00
Autor:
Lucy J Goudswaard, Sean Harrison, Daniel Van De Klee, Nishi Chaturvedi, Debbie A Lawlor, George Davey Smith, Alun D Hughes, Laura D Howe
Publikováno v:
PLoS ONE, Vol 16, Iss 6, p e0253196 (2021)
Greater blood pressure (BP) is associated with greater left ventricular mass indexed to height2.7 (LVMi2.7) in adolescents. This study examined whether greater BP variability and reduced night-time dipping are associated with cardiac remodeling in a
Externí odkaz:
https://doaj.org/article/6c1a3bbc67b2454fb9be9bb20f2247cb
Autor:
Lucy J. Goudswaard, Laura J. Corbin, Kate L. Burley, Andrew Mumford, Parsa Akbari, Nicole Soranzo, Adam S. Butterworth, Nicholas A. Watkins, Dimitri J. Pournaras, Jessica Harris, Nicholas J. Timpson, Ingeborg Hers
Publikováno v:
Platelets, Vol 33, Iss 6, Pp 869-878 (2022)
Higher body mass index (BMI) is a risk factor for thrombosis. Platelets are essential for hemostasis but contribute to thrombosis when activated pathologically. We hypothesized that higher BMI leads to changes in platelet characteristics, thereby inc
Externí odkaz:
https://doaj.org/article/86940295a842420597079a5ed65b1f72
Autor:
Lucy J. Goudswaard, Christopher M. Williams, Jawad Khalil, Kate L. Burley, Fergus Hamilton, David Arnold, Alice Milne, Phil A. Lewis, Kate J. Heesom, Stuart J. Mundell, Andrew D. Davidson, Alastair W. Poole, Ingeborg Hers
Publikováno v:
Journal of Thrombosis and Haemostasis. 21:1307-1321
Autor:
Justin S. Trory, Attila Munkacsi, Kamila M. Śledź, Jordan Vautrinot, Lucy J. Goudswaard, Molly L. Jackson, Kate J. Heesom, Samantha F. Moore, Alastair W. Poole, Behnam Nabet, Varinder K. Aggarwal, Ingeborg Hers
Publikováno v:
Blood Advances. 7:1692-1696
Autor:
Neil J. Goulding, Lucy J. Goudswaard, David A. Hughes, Laura J. Corbin, Alix Groom, Susan Ring, Nicholas J. Timpson, Abigail Fraser, Kate Northstone, Matthew Suderman
Publikováno v:
Goulding, N J, Goudswaard, L, Hughes, D A, Corbin, L J, Groom, A, Ring, S M, Timpson, N J, Fraser, A, Northstone, K & Suderman, M J 2022, ' Inflammation proteomics datasets in the ALSPAC cohort ', Wellcome Open Research . https://doi.org/10.12688/wellcomeopenres.18482.1
Proteomics is the identification, detection and quantification of proteins within a biological sample. The complete set of proteins expressed by an organism is known as the proteome. The availability of new high-throughput proteomic technologies, suc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c62c53a38217e35b3d563c9c23c8fe54
https://research-information.bris.ac.uk/en/publications/0d7b2861-a741-42ef-bf7c-ae1216147019
https://research-information.bris.ac.uk/en/publications/0d7b2861-a741-42ef-bf7c-ae1216147019
Autor:
Lucy J. Goudswaard, Christopher M. Williams, Jawad Khalil, Kate L. Burley, Fergus Hamilton, David Arnold, Alice Milne, Phil A. Lewis, Kate J. Heesom, Stuart J. Mundell, Andrew D. Davidson, Alastair W. Poole, Ingeborg Hers
BackgroundPatients with coronavirus disease-19 (COVID-19) are at increased risk of thrombosis, which is associated with altered platelet function and coagulopathy, contributing to excess mortality.ObjectivesWe aimed to characterise the mechanism of a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2f5d48555bc939a4906b0230ce40577d
https://doi.org/10.1101/2022.10.12.511145
https://doi.org/10.1101/2022.10.12.511145
Autor:
Justin S. Trory, Attila Munkacsi, Kamila M. Śledź, Lucy J. Goudswaard, Kate J. Heesom, Samantha F. Moore, Behnam Nabet, Varinder K. Aggarwal, Ingeborg Hers
The tyrosine kinase BTK plays an important role in platelet function downstream of GPVI and CLEC2 receptors and has been proposed as a novel target to prevent thrombosis in patients that are at increased risk. However, current clinically approved BTK
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1e617c468b2532e8a99fd83249e2f129
https://doi.org/10.1101/2022.05.30.493973
https://doi.org/10.1101/2022.05.30.493973
Autor:
Nicholas J. Timpson, David A. Hughes, Lucy J Goudswaard, Nicole Soranzo, Ingeborg Hers, Adam S. Butterworth, Joshua A. Bell, Klaudia Walter
Publikováno v:
International Journal of Epidemiology. 50
Background Variation in body mass index (BMI) is associated with cardiometabolic health outcomes such as diabetes, but the mechanism(s) leading from BMI to disease remain unclear. This study used proteomic data measured by SomaLogic from healthy adul
Autor:
Molly L Jackson, Haonan Liu, Lucy J Goudswaard, James L Hutchinson, Samantha F. Moore, Ingeborg Hers
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-14 (2021)
Liu, H, Jackson, M L, Goudswaard, L J, Moore, S F, Hutchinson, J L & Hers, I 2021, ' Sphingosine-1-phosphate modulates PAR1-mediated human platelet activation in a concentration-dependent biphasic manner ', Scientific Reports, vol. 11, no. 1, 15308 . https://doi.org/10.1038/s41598-021-94052-4
Scientific Reports
Liu, H, Jackson, M L, Goudswaard, L J, Moore, S F, Hutchinson, J L & Hers, I 2021, ' Sphingosine-1-phosphate modulates PAR1-mediated human platelet activation in a concentration-dependent biphasic manner ', Scientific Reports, vol. 11, no. 1, 15308 . https://doi.org/10.1038/s41598-021-94052-4
Scientific Reports
Sphingosine 1-phosphate (S1P) is a bioactive signalling sphingolipid that is increased in diseases such as obesity and diabetes. S1P can modulate platelet function, however the direction of effect and S1P receptors (S1PRs) involved are controversial.