Corneal avascularity is due to soluble VEGF receptor-1

Autor: Tejvir S. Khurana, Angela Orecchia, Lucy J. Leiper, Jayakrishna Ambati, Sakae Ikeda, Hans-Peter Gerber, Masabumi Shibuya, Yuichiro Ogura, Donna Kwan, Balamurali K. Ambati, Atsunobu Takeda, Judit Z. Baffi, Megan Baldwin, Napoleone Ferrara, B.J. Raisler, Michael T. Newcomb, Qing Lin, P. Jani, Judy St. Leger, Jassir Witta, J. Martin Collinson, Elizabeth Richter, Mark E. Kleinman, Eiji Sakurai, Tushar Suthar, David T. Curiel, Sandro De Falco, Don Samuelson, W. Richard Green, Romulo Albuquerque, Nirbhai Singh, Helene Marsh, Sasha Bogdanovich, Parameshwar J. Mahasreshti, Dalen W. Agnew, Miho Nozaki, Ruth B. Caldwell

Publikováno v: Nature (Lond.) 443 (2006): 993–997. doi:10.1038/nature05249
info:cnr-pdr/source/autori:Ambati B.K.; Nozaki M.; Singh N.; Takeda A.; Jani P.D.; Suthar T.; Albuquerque R.J.; Richter E.; Sakurai E.; Newcomb M.T.; Kleinman M.E.; Caldwell R.B.; Lin Q.; Ogura Y.; Orecchia A.; Samuelson D.A.; Agnew D.W.; St Leger J.; Green W.R.; Mahasreshti P.J.; Curiel D.T.; Kwan D.; Marsh H.; Ikeda S.; Leiper L.J.; Collinson J.M.; Bogdanovich S.; Khurana T.S.; Shibuya M.; Baldwin M.E.; Ferrara N.; Gerber H.P.; De Falco S.; Witta J.; Baffi J.Z.; Raisler B.J.; Ambati J./titolo:Corneal avascularity is due to soluble VEGF receptor-1/doi:10.1038%2Fnature05249/rivista:Nature (Lond.)/anno:2006/pagina_da:993/pagina_a:997/intervallo_pagine:993–997/volume:443

Corneal avascularity—the absence of blood vessels in the cornea—is required for optical clarity and optimal vision, and has led to the cornea being widely used for validating pro- and anti-angiogenic therapeutic strategies for many disorders1-4.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5895895d2d9645d1d550255ce89560d5
https://doi.org/10.1038/nature05249

Cell surface glycoconjugate abnormalities and corneal epithelial wound healing in the pax6+/- mouse model of aniridia-related keratopathy

Autor: Diane Lawson, Lucy J. Leiper, Romana Kucerova, J. Martin Collinson, Jingxing Ou

Publikováno v: Investigative ophthalmologyvisual science. 47(12)

When an epithelium is wounded, a complex series of signaling pathways are initiated in cells radiating from the wound site that promote immediate cell migration into the wound.1-4 Epithelial proliferation is initiated within a few hours, and stem cel

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6a6016b2453727ed69eb802a5a21d29d
https://pubmed.ncbi.nlm.nih.gov/17122113

Control of Patterns of Corneal Innervation by Pax6

Autor: Petr Walczysko, John D. West, Romana Kucerova, Lucy J. Leiper, Derek N. Lavery, Jingxing Ou, J. Martin Collinson

Publikováno v: Leiper, L J, Ou, J X, Walczysko, P, Kucerova, R, Lavery, D N, West, J D & Collinson, J M 2009, ' Control of Patterns of Corneal Innervation by Pax6 ', Investigative Ophthalmology & Visual Science, vol. 50, no. 3, pp. 1122-1128 . https://doi.org/10.1167/iovs.08-2812

The transcription factor PAX6 is essential for eye development and is found in several ocular cell types, including the corneal and limbal epithelia, where gene expression is maintained throughout life.1-4 Heterozygous deficiencies in PAX6 are charac

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::44d6152c4c540f56712d0543d73247ca
https://doi.org/10.1167/iovs.08-2812