Zobrazeno 1 - 3
of 3
pro vyhledávání: '"Lucy H. Elliot"'
Autor:
Pitt Gary Robert William, Andrzej Roman Batt, Paul D. Jenkins, Graeme Semple, Rooker David Philip, Andrew John Baxter, Doreen M. Ashworth, Peter Hudson, D.Michael Evans, David W.M. Benzies, Franklin Richard Jeremy, Yasuo Isomura, Satoshi Yamamoto, Lucy H. Elliot
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 8:959-964
Pyridone-based peptidomimetic inhibitors of recombinant human Interleukin-1 beta-converting enzyme (ICE, caspase-1) with an aminomethylene ketone activating group in the P1' position are described. Several analogues with sub-nanomolar Ki's versus ICE
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4e1ce28144a6a86556fc86ebc2ac3924
https://doi.org/10.1016/s0960-894x(98)00136-x
https://doi.org/10.1016/s0960-894x(98)00136-x
Autor:
Lucy H. Elliot, Pitt Gary Robert William, Franklin Richard Jeremy, Doreen M. Ashworth, Michael Szelke, Satoshi Yamamoto, Andrew John Baxter, Graham R. Baker, D.Michael Evans, Andrew Sheppard, David W.M. Benzies, Graeme Semple, Rooker David Philip, Peter Hudson, Paul D. Jenkins, Andrzej Roman Batt, Yasuo Isomura
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 7:1337-1342
New potent, reversible inhibitors of recombinant human Interleukin-1β-converting enzyme (ICE, caspase-1) with significantly reduced peptide character are described. The compounds were designed by incorporation of pyridone and pyrimidone heterocyclic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::51cb0170ce05f4c726aed52a2ab09800
https://doi.org/10.1016/s0960-894x(97)00220-5
https://doi.org/10.1016/s0960-894x(97)00220-5
Autor:
Y. Isomura, Lucy H. Elliot, Andrew John Baxter, Peter Hudson, S. Yamamoto, Paul D. Jenkins, Andrzej Roman Batt, Doreen M. Ashworth, Graeme Semple, Andrew Sheppard, Michael Szelke, Graham R. Baker, Pitt Gary Robert William, David Michael Evans, David W.M. Benzies, Franklin Richard Jeremy, Rooker David Philip
Publikováno v:
ChemInform. 28
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4ae4f35e5d83594bb3d778a27d6652dc
https://doi.org/10.1002/chin.199739227
https://doi.org/10.1002/chin.199739227