Zobrazeno 1 - 10
of 48
pro vyhledávání: '"Lucy Glover"'
Autor:
Martial Kassi N’Djetchi, Oumou Camara, Mathurin Koffi, Mamadou Camara, Dramane Kaba, Jacques Kaboré, Alkali Tall, Brice Rotureau, Lucy Glover, Mélika Barkissa Traoré, Minayegninrin Koné, Bamoro Coulibaly, Guy Pacome Adingra, Aissata Soumah, Mohamed Gassama, Abdoulaye Dansy Camara, Charlie Franck Alfred Compaoré, Aïssata Camara, Salimatou Boiro, Elena Perez Anton, Paul Bessell, Nick Van Reet, Bruno Bucheton, Vincent Jamonneau, Jean-Mathieu Bart, Philippe Solano, Sylvain Biéler, Veerle Lejon
Publikováno v:
Infectious Diseases of Poverty, Vol 13, Iss 1, Pp 1-16 (2024)
Abstract Background Serological screening tests play a crucial role to diagnose gambiense human African trypanosomiasis (gHAT). Presently, they preselect individuals for microscopic confirmation, but in future “screen and treat” strategies they w
Externí odkaz:
https://doaj.org/article/cddf7d328fd243efa70783ee893348cb
Autor:
Monica Chandra, Sara Đaković, Konstantina Foti, Johan P Zeelen, Monique van Straaten, Francisco Aresta-Branco, Eliane Tihon, Nicole Lübbehusen, Thomas Ruppert, Lucy Glover, F Nina Papavasiliou, C Erec Stebbins
Publikováno v:
PLoS Neglected Tropical Diseases, Vol 17, Iss 2, p e0011093 (2023)
During infection of mammalian hosts, African trypanosomes thwart immunity using antigenic variation of the dense Variant Surface Glycoprotein (VSG) coat, accessing a large repertoire of several thousand genes and pseudogenes, and switching to antigen
Externí odkaz:
https://doaj.org/article/751ce205165247368209f63d3c1aca63
Autor:
Núria Sima, Annick Dujeancourt-Henry, Blanca Liliana Perlaza, Marie-Noelle Ungeheuer, Brice Rotureau, Lucy Glover
Publikováno v:
EBioMedicine, Vol 85, Iss , Pp 104308- (2022)
Summary: Background: To achieve elimination of Human African Trypanosomiasis (HAT) caused by Trypanosoma brucei gambiense (gHAT), the development of highly sensitive diagnostics is needed. We have developed a CRISPR based diagnostic for HAT using SHE
Externí odkaz:
https://doaj.org/article/d1f12cda33154f34804a60140dadf453
Publikováno v:
mBio, Vol 13, Iss 2 (2022)
ABSTRACT In the mammalian host, Trypanosoma brucei is coated in a single-variant surface glycoprotein (VSG) species. Stochastic switching of the expressed VSG allows the parasite to escape detection by the host immune system. DNA double-strand breaks
Externí odkaz:
https://doaj.org/article/88a129a68c75409facefdcd72c7ab6e7
VEX1 Influences mVSG Expression During the Transition to Mammalian Infectivity in Trypanosoma brucei
Autor:
Eliane Tihon, Karinna Rubio-Peña, Annick Dujeancourt-Henry, Aline Crouzols, Brice Rotureau, Lucy Glover
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 10 (2022)
The Trypanosoma (T) brucei life cycle alternates between the tsetse fly vector and the mammalian host. In the insect, T. brucei undergoes several developmental stages until it reaches the salivary gland and differentiates into the metacyclic form, wh
Externí odkaz:
https://doaj.org/article/e3cfad18f8db4caca8a9fb50ec1481c1
Autor:
Alix Thivolle, Ann-Kathrin Mehnert, Eliane Tihon, Emilia McLaughlin, Annick Dujeancourt-Henry, Lucy Glover
Publikováno v:
PLoS Pathogens, Vol 17, Iss 11, p e1010038 (2021)
Antigenic variation is an immune evasion strategy used by Trypanosoma brucei that results in the periodic exchange of the surface protein coat. This process is facilitated by the movement of variant surface glycoprotein genes in or out of a specializ
Externí odkaz:
https://doaj.org/article/31e13eb5031649dba360298ff464beb3
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-14 (2019)
Monoallelic expression of variant surface glycoprotein genes (VSGs) is essential for immune evasion by Trypanosoma brucei. Here, Faria et al. show that the VEX protein complex controls VSG allelic exclusion, and that CAF‐1 sustains inheritance of t
Externí odkaz:
https://doaj.org/article/efa215bb5b8341a084cb1cc4eee142c9
Autor:
Lucy Glover
Publikováno v:
mSphere, Vol 5, Iss 1 (2020)
ABSTRACT Lucy Glover’s research focuses on the role of DNA repair and recombination in antigenic variation in the parasite Trypanosoma brucei, the causative agent of both human and animal African trypanosomiasis. In this mSphere of Influence articl
Externí odkaz:
https://doaj.org/article/8db6244baa2c43bf9dfd4872bbceadda
Publikováno v:
Open Biology, Vol 9, Iss 11 (2019)
African trypanosomes escape the mammalian immune response by antigenic variation—the periodic exchange of one surface coat protein, in Trypanosoma brucei the variant surface glycoprotein (VSG), for an immunologically distinct one. VSG transcription
Externí odkaz:
https://doaj.org/article/96a39d14eb54403c98cc769abab5c306
Publikováno v:
mBio, Vol 10, Iss 4 (2019)
ABSTRACT Damaged DNA typically imposes stringent controls on eukaryotic cell cycle progression, ensuring faithful transmission of genetic material. Some DNA breaks, and the resulting rearrangements, are advantageous, however. For example, antigenic v
Externí odkaz:
https://doaj.org/article/143e3366d41c43898cd4efaedcc625dd