Progesterone receptor expression contributes to gemcitabine resistance at higher ECM stiffness in breast cancer cell lines.

Autor: Emma Grant, Fatma A Bucklain, Lucy Ginn, Peter Laity, Barbara Ciani, Helen E Bryant

Publikováno v: PLoS ONE, Vol 17, Iss 5, p e0268300 (2022)

Chemoresistance poses a great barrier to breast cancer treatment and is thought to correlate with increased matrix stiffness. We developed two-dimensional (2D) polyacrylamide (PAA) and three-dimensional (3D) alginate in vitro models of tissue stiffne

Externí odkaz: https://doaj.org/article/eda66da8f4c74a25a7443d5701b3abd4

Mechanisms of drug resistance mediated by long non-coding RNAs in non-small-cell lung cancer

Autor: Lucy Ginn, Michela Garofalo, Manuela La Montagna

Publikováno v: Cancer Gene Therapy. 28:175-187

Non-small-cell lung cancer (NSCLC) is the most prevalent form of lung cancer and has a poor five-year survival rate of 15%. Chemotherapy and targeted therapies have significantly improved patients' prognosis. Nevertheless, after a successful initial

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::65f1ac71b60f80f966637f6c6004aea8
https://doi.org/10.1038/s41417-020-00214-3

Diverse roles of long non‐coding RNAs in viral diseases

Autor: Lucy Ginn, Qinghua Wu, Manuela La Montagna, Lei Shi

Publikováno v: Reviews in Medical Virology
La Montagna, M, Shi, L & Ginn, L 2020, ' Diverse roles of long non-coding RNAs in viral diseases ', Reviews in Medical Virology . https://doi.org/10.1002/rmv.2198

Summary Viral infection leads to large alterations in the host transcriptome and stimulates an antiviral host immune response involving numerous proteins and signalling pathways. Long non‐coding RNAs (lncRNAs) have emerged as important regulators d

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3d17125c2e4f17c3a39dc0fa0143fa8b

LncRNAs in Non-Small-Cell Lung Cancer

Autor: Michaela Garofalo, Manuela La Montagna, Lei Shi, Lucy Ginn

Publikováno v: Non-Coding RNA, Vol 6, Iss 25, p 25 (2020)
La Montagna, M, Ginn, L, Shi, L & Garofalo, M 2020, ' LncRNAs in non-small-cell lung cancer ', Non-Coding RNA, vol. 6, no. 3, 25 . https://doi.org/10.3390/NCRNA6030025
Non-Coding RNA

Lung cancer is associated with a high mortality, with around 1.8 million deaths worldwide in 2018. Non-small-cell lung cancer (NSCLC) accounts for around 85% of cases and, despite improvement in the management of NSCLC, most patients are diagnosed at

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::afc0d4a84642e6b6916af4b68737f171
https://www.mdpi.com/2311-553X/6/3/25