Zobrazeno 1 - 10
of 51
pro vyhledávání: '"Lucy G. Andrews"'
Publikováno v:
International Journal of Cancer. 125:286-296
Genistein, a natural isoflavone found in soybean products, has been reported to down-regulate telomerase activity and that this prevents cancer and contributes to the apoptosis of cancer cells. However, the precise molecular mechanism by which genist
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::96658d5ab01ea1c2a49a2e3817f696a1
https://doi.org/10.1002/ijc.24398
https://doi.org/10.1002/ijc.24398
Autor:
Lucy G. Andrews, Santosh K. Katiyar, Trygve O. Tollefsbol, William K. Love, Joel B. Berletch, Can-hui Liu
Publikováno v:
Journal of Cellular Biochemistry. 103:509-519
The ends of human chromosomes are protected from the degradation associated with cell division by 15-20 kb long segments of hexameric repeats of 5′-TTAGGG-3′ termed telomeres. In normal cells telomeres lose up to 300 bp of DNA per cell division t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2708207417aa6090afaccc6bbcebf322
https://doi.org/10.1002/jcb.21417
https://doi.org/10.1002/jcb.21417
Publikováno v:
Current Medicinal Chemistry. 13:2875-2888
Current standard cancer therapies (chemotherapy and radiation) often cause serious adverse off-target effects. Drug design strategies are therefore being developed that will more precisely target cancer cells for destruction while leaving surrounding
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::608c9d054110be32416d6f7b4c9e03d6
https://doi.org/10.2174/092986706778521887
https://doi.org/10.2174/092986706778521887
Autor:
Lucy G. Andrews, Joel B. Berletch, Jessica G. Green, Amanda P. Cunningham, Trygve O. Tollefsbol
Publikováno v:
Current Pharmacogenomics. 2:313-324
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::eb64afa8c266f34df66259715b81f170
https://doi.org/10.2174/1570160043377321
https://doi.org/10.2174/1570160043377321
Autor:
Liang Liu, Joel B. Berletch, Jessica G. Green, Mitchell S. Pate, Lucy G. Andrews, Trygve O. Tollefsbol
Publikováno v:
Molecular Cancer Therapeutics. 3:1003-1009
Human promyelocytic leukemia HL60 cells display high telomerase activity, a phenotype related to their immortal status. All-trans retinoic acid (ATRA) is a clinically effective cytodifferentiating agent. To understand the mechanism underlying ATRA-in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8de0ea68a632217db5472a73876e30ce
https://doi.org/10.1158/1535-7163.1003.3.8
https://doi.org/10.1158/1535-7163.1003.3.8
Publikováno v:
Mechanisms of Ageing and Development. 124:989-998
Cancer and aging are two coupled developmental processes as reflected by the higher incidence of cancer in the elderly human population group. Genetic mutations accumulate in somatic cells with age, which may explain in part the association of age wi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7927477b9395cf614701a5b4cb0cae17
https://doi.org/10.1016/j.mad.2003.08.001
https://doi.org/10.1016/j.mad.2003.08.001
Autor:
Lucy G. Andrews, Mark A Pita, Nathaniel J. Hansen, Sabita N. Saldanha, Jason S Key, Joseph C Poole, Nadejda Lopatina, Trygve O. Tollefsbol
Publikováno v:
Biochemical and Biophysical Research Communications. 306:650-659
Telomerase is active in about 90% of cancers and contributes to the immortality of cancer cells by maintaining the lengths of the ends of chromosomes. Undifferentiated embryonic human teratocarcinoma (HT) cells were found to express high levels of hT
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::864a021d0daf24d30e023a46cd0e0e18
https://doi.org/10.1016/s0006-291x(03)01033-7
https://doi.org/10.1016/s0006-291x(03)01033-7
Publikováno v:
Analytical Biochemistry. 315:1-21
The discovery of the enzyme telomerase and its subunits has led to major advances in understanding the mechanisms of cellular proliferation, immortalization, aging, and neoplastic transformation. The expression of telomerase in more than 85% of tumor
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3921f84ea2534f1193432429a1250d66
https://doi.org/10.1016/s0003-2697(02)00663-2
https://doi.org/10.1016/s0003-2697(02)00663-2
Autor:
Trygve O. Tollefsbol, Sabita N. Saldanha, Lucy G. Andrews, Joyce F. Haskell, Joseph C Poole, Nadejda Lopatina
Publikováno v:
Journal of Cellular Biochemistry. 84:324-334
Genomic methylation, which influences many cellular processes such as gene expression and chromatin organization, generally declines with cellular senescence although some genes undergo paradoxical hypermethylation during cellular aging and immortali
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bad32cee6d2db12789f1b40f1e2d4689
https://doi.org/10.1002/jcb.10015
https://doi.org/10.1002/jcb.10015
Autor:
Trygve O. Tollefsbol, Lucy G. Andrews
Publikováno v:
Medical Hypotheses. 56:630-637
Although telomerase, which maintains the ends of chromosomes, is down-regulated as cells differentiate leading to attrition of chromosomal termini and ultimate replicative senescence, it is up-regulated in most cancer cells which show no net loss of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d964c28550bb1277cff42cd46f473674
https://doi.org/10.1054/mehy.2000.1241
https://doi.org/10.1054/mehy.2000.1241