Zobrazeno 1 - 8
of 8
pro vyhledávání: '"Lucy Findlay"'
Publikováno v:
ALTEX. :47-53
The rabbit pyrogen test was developed in the early 1900's to detect contaminating pyrogens in parenteral medicines. Since its conception alternative methods with improved sensitivity, relevancy and which are ethically more acceptable have been develo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::94053d305d4a3f66453d9a4e53ffad2e
https://doi.org/10.14573/altex.1509291
https://doi.org/10.14573/altex.1509291
Autor:
Meenu Wadhwa, David Eastwood, Susan J. Thorpe, Chris Bird, Paula Dilger, Lucy Findlay, Stephen Poole, Richard Stebbings, Robin Thorpe, Jason Hockley
Publikováno v:
British Journal of Clinical Pharmacology
Aim To determine if cytokine release with a solid phase assay is predictive of adverse responses for a range of therapeutic mAbs. Methods Cytokine ELISAs and a multi-array system were used to compare responses generated by different therapeutic mAbs
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::929329117f2a06d2fcb093c474b38bf8
https://doi.org/10.1111/bcp.12165
https://doi.org/10.1111/bcp.12165
Autor:
Giles Sharp, Christina Ball, Stephen Poole, Richard Stebbings, Adrian Bristow, Lucy Findlay, Paul W. H. I. Parren, Susan J. Thorpe, Bernard Fox, Simon E. Hufton, Robin Thorpe, David Eastwood
Publikováno v:
The Journal of Immunology. 189:5831-5840
The unexpected outcome of the clinical trial of the superagonistic CD28 mAb TGN1412 (IgG4κ) continues to stimulate interest. We show that TGN1412 binds similarly to human and cynomolgus macaque FcγR, eliminating the possibility that differences in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3074059840d57854618bc4d6cebb6430
https://doi.org/10.4049/jimmunol.1201795
https://doi.org/10.4049/jimmunol.1201795
Autor:
Chris Bird, Richard Stebbings, Robin Thorpe, Lucy Findlay, Susan J. Thorpe, David Eastwood, C. Jane Robinson, Stephen Poole, Christina Ball, Meenu Wadhwa
Publikováno v:
Journal of Immunological Methods. 371:134-142
Two methods for predicting the risk of pro-inflammatory clinical infusion reactions during monoclonal antibody therapy were evaluated. In the first, the antibody of interest is immobilised by air-drying onto 96-well plates prior to the addition of hu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3eecc34f783065e9e6ca0baea4c45aac
https://doi.org/10.1016/j.jim.2011.06.022
https://doi.org/10.1016/j.jim.2011.06.022
Autor:
Richard Stebbings, Susan J. Thorpe, Giles Sharp, Meenu Wadhwa, Robin Thorpe, Chris Bird, C. Jane Robinson, Stephen Poole, Bernard Fox, David Eastwood, Christina Ball, Lucy Findlay
Publikováno v:
Cytokine. 55:141-151
The failure of preclinical testing to predict the severity of the cytokine storm experienced by the recipients of the superagonistic anti-CD28 monoclonal antibody (mAb) TGN1412 during its Phase 1 clinical trial prompted the development of new in vitr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::25dd27809fda531430baa204b577cc63
https://doi.org/10.1016/j.cyto.2011.03.019
https://doi.org/10.1016/j.cyto.2011.03.019
Autor:
David Eastwood, Lucy Findlay, Robin Thorpe, Christina Ball, Stephen Poole, Richard Stebbings, Giles Sharp, Yogesh Mistry, John Hood
Publikováno v:
Journal of Immunological Methods. 352:1-12
TGN1412 is a "superagonistic" CD28 monoclonal antibody (IgG4) that caused serious adverse events at its first time in human clinical trial. In the present study, different in vitro methods for detecting and quantifying unwanted pro-inflammatory activ
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7bfe1a9de10167a036356e48f902e927
https://doi.org/10.1016/j.jim.2009.10.013
https://doi.org/10.1016/j.jim.2009.10.013
Autor:
Yogesh Mistry, Emily C. Liefooghe, David North, Isabelle Cludts, Cherry Edwards, Lucy Findlay, Robin Thorpe, Carl Dolman, Jane Robinson, David Eastwood, Stephen Poole, Adrian Bristow, Chris Bird, Susan J. Thorpe, Meenu Wadhwa, Tony Meager, P. Dilger, Gill Tarrant, Richard Stebbings, Bernard Fox
Publikováno v:
The Journal of Immunology. 179:3325-3331
The CD28-specific mAb TGN1412 rapidly caused a life-threatening “cytokine storm” in all six healthy volunteers in the Phase I clinical trial of this superagonist, signaling a failure of preclinical safety testing. We report novel in vitro procedu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d2cef95ee329534f8bc706f74ef5ab45
https://doi.org/10.4049/jimmunol.179.5.3325
https://doi.org/10.4049/jimmunol.179.5.3325
Autor:
Richard Stebbings, David Eastwood, Lucy Findlay, Stephen Poole, Robin Thorpe, Susan J. Thorpe
Publikováno v:
Cytokine. 64(1)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8690d97202c9aaef0242afbe0c4f9776
https://pubmed.ncbi.nlm.nih.gov/23921146
https://pubmed.ncbi.nlm.nih.gov/23921146