Zobrazeno 1 - 10
of 85
pro vyhledávání: '"Lucy F Donaldson"'
Publikováno v:
F1000Research, Vol 7 (2018)
Central nervous system (CNS) pericytes regulate critical functions of the neurovascular unit in health and disease. CNS pericytes are an attractive pharmacological target for their position within the neurovasculature and for their role in neuroinfla
Externí odkaz:
https://doaj.org/article/9bcb6daffd72413e9c151c4ecc3ab294
Autor:
Roaa H. Alalwany, Tom Hawtrey, Kevin Morgan, Jonathan C. Morris, Lucy F. Donaldson, David O. Bates
Publikováno v:
Frontiers in Molecular Neuroscience, Vol 16 (2023)
Alzheimer’s disease (AD) is the most common cause of dementia, the chronic and progressive deterioration of memory and cognitive abilities. AD can be pathologically characterised by neuritic plaques and neurofibrillary tangles, formed by the aberra
Externí odkaz:
https://doaj.org/article/440c5e871b4a4cc58d6172dcaed53313
Autor:
Bridget M. Lumb, Lucy F. Donaldson
Publikováno v:
Frontiers in Pain Research, Vol 3 (2022)
Descending pain modulatory systems (DPMS) that originate within the brain and act to modulate spinal nociceptive transmission are a major determinant of the acute and chronic pain experience. Investigations of these systems in basic scientific resear
Externí odkaz:
https://doaj.org/article/3584bc4e569642aebbfc694b36509e49
Publikováno v:
Neurobiology of Disease, Vol 96, Iss , Pp 186-200 (2016)
Neuropathic pain results from neuroplasticity in nociceptive neuronal networks. Here we demonstrate that control of alternative pre-mRNA splicing, through the splice factor serine-arginine splice factor 1 (SRSF1), is integral to the processing of noc
Externí odkaz:
https://doaj.org/article/48cc6e43d9a74931b454519581875e44
Autor:
Marlene E. Da Vitoria Lobo, Nick Weir, Lydia Hardowar, Yara Al Ojaimi, Ryan Madden, Alex Gibson, Samuel M. Bestall, Masanori Hirashima, Chris B. Schaffer, Lucy F. Donaldson, David O. Bates, Richard Philip Hulse
Publikováno v:
Pain. 163:2264-2279
Neuropathic pain, such as that seen in diabetes mellitus, results in part from central sensitisation in the dorsal horn. However, the mechanisms responsible for such sensitisation remain unclear. There is evidence that disturbances in the integrity o
Autor:
Lucy F Donaldson, Ramiro Alberio, Jennifer Batson, Frances Henson, Roger Lemon, Anna Mitchell, Jo Murrell, Domingo Tortonese
Publikováno v:
Physiology News. :18-22
Autor:
Lucy F. Donaldson, Andrew W. Trafford
Publikováno v:
Physiology News.
Publikováno v:
Neurobiology of Disease, Vol 17, Iss 1, Pp 62-69 (2004)
Cation chloride cotransporters have been proposed to play a role in the modulation of neuronal responses to γ-aminobutyric acid (GABA). In conditions of neuronal damage, where neuronal excitability is increased, the expression of the KCC2 transporte
Externí odkaz:
https://doaj.org/article/31ae5ef823c34ce5aee87de95e57d97f
Autor:
Lucy F Donaldson, Cheryl L. Stucky
Publikováno v:
Current Opinion in Physiology. 11:iii-v
Autor:
Richard P. Hulse, David O. Bates, Lucy F. Donaldson, William Robert Ashby, Fatimah Almahasneh, Alexandra M. Durrant, Samuel M. Bestall, Catherine E. Moss, Kurt Ballmer-Hofer, Andrew V. Benest, Nicholas Beazley-Long, Zoe Blackley, Masanori Hirashima
Publikováno v:
Brain, Behavior, and Immunity
BRAIN BEHAVIOR AND IMMUNITY
BRAIN BEHAVIOR AND IMMUNITY
Highlights • Targeting VEGFR2 prevents secondary allodynia in inflammatory arthritis models. • Anti-VEGFR2 reduces vascular ICAM-1 and microglia in the dorsal horn. • Anti-VEGFR2 inhibits monocyte attachment to brain endothelial cells. • We p