Zobrazeno 1 - 10
of 13
pro vyhledávání: '"Lucy E. Walmsley"'
Autor:
Qingshan Teng, Mary Garrity-Moses, Thais Federici, Diana Tanase, James K. Liu, Nicholas D. Mazarakis, Mimoun Azzouz, Lucy E. Walmsley, Erin Carlton, Nicholas M. Boulis
Publikováno v:
Neurobiology of Disease, Vol 20, Iss 3, Pp 694-700 (2005)
The present study examines gene delivery to cultured motor neurons (MNs) with the Rabies G protein (RabG)-pseudotyped lentiviral equine infectious anemia virus (RabG.EIAV) vector. RabG.EIAV-mediated β-galactosidase (RabG.EIAV-LacZ) gene expression i
Externí odkaz:
https://doaj.org/article/fadd0179677e4a0992f20be438f51d4e
Autor:
Nicholas D. Mazarakis, Mary E. Garrity-Moses, Lucy E. Walmsley, Mimoun Azzouz, Erin Carlton, James K. Liu, Diana Tanase, Qingshan Teng, Nicholas M. Boulis, Thais Federici
Publikováno v:
Neurobiology of Disease, Vol 20, Iss 3, Pp 694-700 (2005)
The present study examines gene delivery to cultured motor neurons (MNs) with the Rabies G protein (RabG)-pseudotyped lentiviral equine infectious anemia virus (RabG.EIAV) vector. RabG.EIAV-mediated β-galactosidase (RabG.EIAV-LacZ) gene expression i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5d1f88c0fb7ac89886812019097ea8cb
https://doi.org/10.1016/j.nbd.2005.05.016
https://doi.org/10.1016/j.nbd.2005.05.016
Autor:
Mimoun Azzouz, Umrao R. Monani, G. Scott Ralph, Fraser J. Wilkes, Debbie C.P. Lee, Susan M. Kingsman, Lucy E. Walmsley, Arthur H.M. Burghes, Kyriacos A. Mitrophanous, Nicholas D. Mazarakis, Thanh Le
Publikováno v:
Journal of Clinical Investigation. 114:1726-1731
Spinal muscular atrophy (SMA) is a frequent recessive autosomal disorder. It is caused by mutations or deletion of the telomeric copy of the survival motor neuron (SMN) gene, leading to depletion in SMN protein levels. The treatment rationale for SMA
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8203d3554a255d105539071a8bc9d16f
https://doi.org/10.1172/jci22922
https://doi.org/10.1172/jci22922
Lentiviral-mediated delivery of Bcl-2 or GDNF protects against excitotoxicity in the rat hippocampus
Autor:
Stephen Parham, Susan M. Kingsman, Nicholas D. Mazarakis, G. Scott Ralph, Liang-Fong Wong, Alison S. Bienemann, James B. Uney, Lucy E. Walmsley
Publikováno v:
Molecular therapy : the journal of the American Society of Gene Therapy. 11(1)
Nutrient deprivation during ischemia leads to severe insult to neurons causing widespread excitotoxic damage in specific brain regions such as the hippocampus. One possible strategy for preventing neurodegeneration is to express therapeutic proteins
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9915679cdb836e6544b8f93bec98d202
https://pubmed.ncbi.nlm.nih.gov/15585409
https://pubmed.ncbi.nlm.nih.gov/15585409
Autor:
L Lawrence, Kyriacos A. Mitrophanous, Lucy E. Walmsley, Brian W. Bigger, Simon N. Waddington, Maxine V. Holder, Charles Coutelle, Michael Themis, Faisal A. Al-Allaf, Suzanne M. K. Buckley, K. Mosley, Susan M. Kingsman, Lisa G. Gregory, F M Ellard
Publikováno v:
Gene therapy. 11(14)
Gene therapy for Duchenne muscular dystrophy has so far not been successful because of the difficulty in achieving efficient and permanent gene transfer to the large number of affected muscles and the development of immune reactions against vector an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::63927d02dc00801557fca456fafb0991
https://pubmed.ncbi.nlm.nih.gov/15141156
https://pubmed.ncbi.nlm.nih.gov/15141156
Autor:
Susan M. Kingsman, Mimoun Azzouz, Peter Carmeliet, Kyriacos A. Mitrophanous, G. Scott Ralph, Nicholas D. Mazarakis, Lucy E. Walmsley, Erik Storkebaum
Publikováno v:
Nature. 429(6990)
Amyotrophic lateral sclerosis (ALS) causes adult-onset, progressive motor neuron degeneration in the brain and spinal cord, resulting in paralysis and death three to five years after onset in most patients. ALS is still incurable, in part because its
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::127e0e4233cd81995f99d7c11ed965ca
https://pubmed.ncbi.nlm.nih.gov/15164063
https://pubmed.ncbi.nlm.nih.gov/15164063
Autor:
Nicholas D. Mazarakis, Susan M. Kingsman, Lucy E. Walmsley, Kyriacos A. Mitrophanous, Liang-Fong Wong, Mimoun Azzouz, Zoe Askham, Fraser J. Wilkes
Publikováno v:
Molecular therapy : the journal of the American Society of Gene Therapy. 9(1)
We have developed a non-primate-based lentiviral vector based on the equine infectious anemia virus (EIAV) for efficient gene transfer to the central and peripheral nervous systems. Previously we have demonstrated that pseudotyping lentiviral vectors
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ee08fe95ff25fb8f9dcd00eec52c3627
https://pubmed.ncbi.nlm.nih.gov/14741783
https://pubmed.ncbi.nlm.nih.gov/14741783
Autor:
Suzanne M. K. Buckley, Charles Coutelle, Pippa A Radcliffe, Terrence Cook, L Lawrence, Michael Themis, Kyriacos A. Mitrophanous, Nick Mazarakis, Faisal A. Allaf, Lisa G. Gregory, Brian W. Bigger, Susan M. Kingsman, Fiona E. Ellard, Mimoun Azzouz, Simon N. Waddington, Maxine V. Holder, Lucy E. Walmsley
Publikováno v:
Molecular Therapy. 9:S91
Top of pageAbstract Gene therapy for Duchenne muscular dystrophy has so far not been successful because of the difficulty in achieving efficient and permanent gene transfer to the large number of affected muscles and the development of immune reactio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5f89556863558f552625dbcadb5159c0
https://doi.org/10.1016/j.ymthe.2004.06.164
https://doi.org/10.1016/j.ymthe.2004.06.164
Autor:
James K. Liu, Qingshan Teng, Mimoun Azzouz, Lucy E. Walmsley, Nicholas D. Mazarakis, Diana Tanase, Ajit A. Krishnaney, Nicholas M. Boulis, Mary E. Garrity-Moses
Publikováno v:
Molecular Therapy. 9:S201
Objective: Recent work has suggested that injection of lentiviral vectors might constitute means of therapeutic gene delivery to diseased motor neurons in ALS. However, as implied by the name, Amyotrophic Lateral Sclerosis, this disorder results in s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0db4d43617790dfb160e4a9e55746954
https://doi.org/10.1016/j.ymthe.2004.06.479
https://doi.org/10.1016/j.ymthe.2004.06.479
Autor:
Liang-Fong Wong, Mimoun Azzouz, Nicholas D. Mazarakis, Fraser J. Wilkes, Lucy E. Walmsley, Zoe Askham, Kyriacos A. Mitrophanous, Susan M. Kingsman
Publikováno v:
Molecular Therapy. 9:765
The publisher regrets that a proof correction requested by the author was misinterpreted. On page 109, left-hand column, lines 15 and 16 should read: "In differentiated PC12 cells, p75NTR has been shown to internalize into vesicles bound to its ligan
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4335cdd199449eb90265467423fdab29
https://doi.org/10.1016/j.ymthe.2004.01.020
https://doi.org/10.1016/j.ymthe.2004.01.020