Zobrazeno 1 - 8
of 8
pro vyhledávání: '"Lucy E. Durham"'
Autor:
Giovanni A.M. Povoleri, Lucy E. Durham, Elizabeth H. Gray, Sylvine Lalnunhlimi, Shichina Kannambath, Michael J. Pitcher, Pawan Dhami, Thomas Leeuw, Sarah E. Ryan, Kathryn J.A. Steel, Bruce W. Kirkham, Leonie S. Taams
Publikováno v:
Cell Reports, Vol 42, Iss 5, Pp 112514- (2023)
Summary: CD69+CD103+ tissue-resident memory T (TRM) cells are important drivers of inflammation. To decipher their role in inflammatory arthritis, we apply single-cell, high-dimensional profiling to T cells from the joints of patients with psoriatic
Externí odkaz:
https://doaj.org/article/7c887f70768745f6826a22484fb9b917
Autor:
Elizabeth H. Gray, Ushani Srenathan, Lucy E. Durham, Sylvine Lalnunhlimi, Kathryn J. A. Steel, Anca Catrina, Bruce W. Kirkham, Leonie S. Taams
IL-17A+ CD8+ T-cells, often referred to as Tc17 cells, have been identified at sites of inflammation in several immune-mediated inflammatory diseases including psoriasis and spondyloarthritis. Whilst much of our understanding of IL-17A+ CD8+ T-cells
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0f85020ba6b65f166f544b8773ae9583
https://doi.org/10.1101/2022.11.14.516164
https://doi.org/10.1101/2022.11.14.516164
Autor:
Estee Chan, Ushani Srenathan, Catherine Dawn Hughes, Michael Ridley, Leonie S. Taams, Shih Ying Wu, Sarah Ryan, Bruce Kirkham, Lucy E. Durham, Kathryn J. A. Steel
Publikováno v:
Steel, K J A, Srenathan, U, Ridley, M, Durham, L E, Wu, S Y, Ryan, S E, Hughes, C D, Chan, E, Kirkham, B W & Taams, L S 2020, ' Polyfunctional, Proinflammatory, Tissue-Resident Memory Phenotype and Function of Synovial Interleukin-17A+CD8+ T Cells in Psoriatic Arthritis ', Arthritis and Rheumatology, vol. 72, no. 3, pp. 435-447 . https://doi.org/10.1002/art.41156
Steel, K J A, Srenathan, U, Ridley, M L, Durham, L, Wu, S Y, Ryan, S, Hughes, C D, Chan, E, Kirkham, B & Taams, L 2020, ' Polyfunctional, Proinflammatory, Tissue-Resident Memory Phenotype and Function of Synovial Interleukin-17A+CD8+ T Cells in Psoriatic Arthritis ', Arthritis & rheumatology, vol. 72, no. 3, pp. 435-447 . https://doi.org/10.1002/art.41156
Arthritis & Rheumatology (Hoboken, N.j.)
Steel, K J A, Srenathan, U, Ridley, M L, Durham, L, Wu, S Y, Ryan, S, Hughes, C D, Chan, E, Kirkham, B & Taams, L 2020, ' Polyfunctional, Proinflammatory, Tissue-Resident Memory Phenotype and Function of Synovial Interleukin-17A+CD8+ T Cells in Psoriatic Arthritis ', Arthritis & rheumatology, vol. 72, no. 3, pp. 435-447 . https://doi.org/10.1002/art.41156
Arthritis & Rheumatology (Hoboken, N.j.)
Objective: Genetic associations imply a role for CD8+ T cells and the interleukin-23 (IL-23)/IL-17 axis in psoriatic arthritis (PsA) and other spondyloarthritides (SpA). IL-17A+CD8+ (Tc17) T cells are enriched in the synovial fluid (SF) of patients w
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ad9dc61ad2b349a4ed2e5f8f0add4027
https://doi.org/10.1002/art.41156
https://doi.org/10.1002/art.41156
Publikováno v:
Current Rheumatology Reports. 23
The recognition that IL-17 is produced by many lymphoid-like cells other than CD4+ T helper (Th17) cells raises the potential for new pathogenic pathways in IBD/psoriasis/SpA. We review recent knowledge concerning the role of unconventional and conve
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7219c89c743000ba7984a6fba432ed89
https://doi.org/10.1007/s11926-021-01005-x
https://doi.org/10.1007/s11926-021-01005-x
Publikováno v:
Frontiers in Immunology
Roberts, C A, Durham, L E, Fleskens, V, Evans, H G & Taams, L S 2017, ' TNF blockade maintains an IL-10+ phenotype in human effector CD4+ and CD8+ T cells ', Frontiers in Immunology, vol. 8, 157 . https://doi.org/10.3389/fimmu.2017.00157
Roberts, C A, Durham, L E, Fleskens, V, Evans, H G & Taams, L S 2017, ' TNF blockade maintains an IL-10+ phenotype in human effector CD4+ and CD8+ T cells ', Frontiers in Immunology, vol. 8, 157 . https://doi.org/10.3389/fimmu.2017.00157
CD4+ and CD8+ effector T cell subpopulations can display regulatory potential characterized by expression of the prototypically anti-inflammatory cytokine IL-10. However, the underlying cellular mechanisms that regulate expression of IL-10 in differe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1c2778afb1fae8acf276d98bc1f51a47
https://doi.org/10.3389/fimmu.2017.00157
https://doi.org/10.3389/fimmu.2017.00157
Publikováno v:
Current rheumatology reports. 17(8)
Investigators have accrued compelling evidence that the IL-17 pathway is central to the pathogenesis of psoriasis and psoriatic arthritis. The evidence comprises genome-wide association studies (GWAS), data from experimental murine models and finding
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::641ddcdd4d3fb2a99b43e3da7b34ecee
https://pubmed.ncbi.nlm.nih.gov/26209291
https://pubmed.ncbi.nlm.nih.gov/26209291
Autor:
Lucy E, Durham
Publikováno v:
BMJ (Clinical research ed.). 342
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::aaffe6407c59e88a6d9e310c3f56f312
https://pubmed.ncbi.nlm.nih.gov/21478236
https://pubmed.ncbi.nlm.nih.gov/21478236
Autor:
Lucy E Durham
Publikováno v:
BMJ. 342:d2294-d2294
Recent guidelines on food allergy in children and young people from the National Institute for Health and Clinical Excellence (NICE) emphasise that eczema should trigger clinicians to focus on allergy when taking a history—namely, the nature of the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e0f7af3c64681c48dd73833c37c250a9
https://doi.org/10.1136/bmj.d2294
https://doi.org/10.1136/bmj.d2294