Zobrazeno 1 - 10
of 18
pro vyhledávání: '"Lucy C Young"'
Autor:
Anne E Roehrig, Kristina Klupsch, Juan A Oses-Prieto, Selim Chaib, Stephen Henderson, Warren Emmett, Lucy C Young, Silvia Surinova, Andreas Blees, Anett Pfeiffer, Maha Tijani, Fabian Brunk, Nicole Hartig, Marta Muñoz-Alegre, Alexander Hergovich, Barbara H Jennings, Alma L Burlingame, Pablo Rodriguez-Viciana
Publikováno v:
PLoS ONE, Vol 16, Iss 8, p e0254697 (2021)
The PAF complex (PAFC) coordinates transcription elongation and mRNA processing and its CDC73/parafibromin subunit functions as a tumour suppressor. The NF2/Merlin tumour suppressor functions both at the cell cortex and nucleus and is a key mediator
Externí odkaz:
https://doaj.org/article/060b7e02b03d49888281c2e401c2133d
Autor:
Lucy C. Young, Ruby Goldstein de Salazar, Sae-Won Han, Zi Yi Stephanie Huang, Alan Merk, Matthew Drew, Joseph Darling, Vanessa Wall, Reinhard Grisshammer, Alice Cheng, Madeline R. Allison, Matthew J. Sale, Dwight V. Nissley, Dominic Esposito, Jana Ognjenovic, Frank McCormick
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America, vol 120, iss 5
The majority of pathogenic mutations in the neurofibromatosis type I ( NF1 ) gene reduce total neurofibromin protein expression through premature truncation or microdeletion, but it is less well understood how loss-of-function missense variants drive
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::42467259853d995e6612da3438b31efe
https://escholarship.org/uc/item/19n3q41h
https://escholarship.org/uc/item/19n3q41h
Autor:
Greg G. Jones, Sibel Sari, Pablo Rodriguez-Viciana, Nicole Hartig, Amandeep Bhamra, Ewa Rejnowicz, Isabel Boned del Río, Benjamin Ringham-Terry, Winnie Lei, Lucy C. Young, Silvia Surinova
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America
Proceedings of the National Academy of Sciences of the United States of America, vol 116, iss 27
Proceedings of the National Academy of Sciences of the United States of America, vol 116, iss 27
Significance The ERK signaling pathway is hyperactivated in a majority of cancers. However, because it mediates myriad physiological responses, the clinical efficacy of current ERK pathway inhibitors has been severely limited by toxicity. This study
Autor:
Timothy H. Tran, Srisathiyanarayanan Dharmaiah, Troy Taylor, Simon Messing, Dhirendra K. Simanshu, John-Paul Denson, Albert H. Chan, Lakshman Bindu, Dwight V. Nissley, Dominic Esposito, Andrew G. Stephen, Chris Neale, Lucy C. Young, Frank McCormick
Publikováno v:
Nature communications, vol 12, iss 1
Nature Communications, Vol 12, Iss 1, Pp 1-16 (2021)
Nature Communications
Nature Communications, Vol 12, Iss 1, Pp 1-16 (2021)
Nature Communications
The first step of RAF activation involves binding to active RAS, resulting in the recruitment of RAF to the plasma membrane. To understand the molecular details of RAS-RAF interaction, we present crystal structures of wild-type and oncogenic mutants
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d06bfdad1f48da07a90cbefcedbdeea8
https://escholarship.org/uc/item/4z27z91n
https://escholarship.org/uc/item/4z27z91n
Autor:
Alma L. Burlingame, Warren Emmett, Andreas Blees, Fabian Brunk, Silvia Surinova, Anne E. Roehrig, Marta Munoz-Alegre, Alexander Hergovich, Kristina Klupsch, Maha Tijani, Anett Pfeiffer, Juan A. Oses-Prieto, Stephen Henderson, Pablo Rodriguez-Viciana, Nicole Hartig, Selim Chaib, Barbara H. Jennings, Lucy C. Young
Publikováno v:
PloS one, vol 16, iss 8
PLoS ONE
PLoS ONE, Vol 16, Iss 8, p e0254697 (2021)
PLoS ONE
PLoS ONE, Vol 16, Iss 8, p e0254697 (2021)
The PAF complex (PAFC) coordinates transcription elongation and mRNA processing and its CDC73/parafibromin subunit functions as a tumour suppressor. The NF2/Merlin tumour suppressor functions both at the cell cortex and nucleus and is a key mediator
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::230e0538a32a3dbbdd2c44b48de833dd
https://escholarship.org/uc/item/57d9s6th
https://escholarship.org/uc/item/57d9s6th
Autor:
Stephen Henderson, Alma L. Burlingame, Marta Munoz-Alegre, Alexander Hergovich, A. E. Roehrigh, Juan A. Oses-Prieto, Pablo Rodriguez-Viciana, A. Blees, K. Klupsch, Barbara H. Jennings, Nicole Hartig, Warren Emmett, Silvia Surinova, F. Brunk, A. Pfeiffer, S. Chaib, Maha Tijani, Lucy C. Young
SUMMARYThe PAF complex (PAFC) coordinates transcription elongation and mRNA processing events and its CDC73/parafibromin subunit functions as a tumour suppressor. The NF2/Merlin tumour suppressor functions at the cell cortex and nucleus and is a key
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ebfa1052b053cce99932ff3d641a4d05
https://doi.org/10.1101/717769
https://doi.org/10.1101/717769
Autor:
Sibel Sari, Nicole Hartig, Aysen Sekerim, Julian Downward, Itziar Areso Zubiaur, Miriam Molina-Arcas, Winnie Lei, Greg G. Jones, Isabel Boned del Río, Lucy C. Young, Mona El-Bahrawy, Pablo Rodriguez-Viciana, Robert E. Hynds
Publikováno v:
Nature Communications
Nature Communications, Vol 10, Iss 1, Pp 1-16 (2019)
Nature communications, vol 10, iss 1
Nature Communications, Vol 10, Iss 1, Pp 1-16 (2019)
Nature communications, vol 10, iss 1
Targeted inhibition of the ERK-MAPK pathway, upregulated in a majority of human cancers, has been hindered in the clinic by drug resistance and toxicity. The MRAS-SHOC2-PP1 (SHOC2 phosphatase) complex plays a key role in RAF-ERK pathway activation by
Autor:
Frank McCormick, Greg G. Jones, Joshua R. Wainwright, Lucy C. Young, Nicole Hartig, Benjamin Ringham-Terry, Sibel Sari, Isabel Boned del Río, Pablo Rodriguez-Viciana
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America, vol 115, iss 45
Dephosphorylation of the inhibitory "S259" site on RAF kinases (S259 on CRAF, S365 on BRAF) plays a key role in RAF activation. The MRAS GTPase, a close relative of RAS oncoproteins, interacts with SHOC2 and protein phosphatase 1 (PP1) to form a hete
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::043fd74764d8eeaa7289fdbb429b878f
https://escholarship.org/uc/item/9ct3g7st
https://escholarship.org/uc/item/9ct3g7st
Publikováno v:
Cancer Research. 80:3765-3765
Spred1 negatively regulates Ras/MAPK signaling following growth factor stimulation. Spred1 inhibits Ras by binding and localizing Neurofibromin, a RasGAP, to the plasma membrane to accelerate Ras GTPase activity. c-Kit, a receptor tyrosine kinase (RT
Autor:
Sibel Sari, Isabel Boned del Río, Julian Downward, Nicole Hartig, Mona El-Bahrawy, Aysen Sekerim, Pablo Rodriguez-Viciana, Miriam Molina-Arcas, Greg G. Jones, Lucy C. Young
Publikováno v:
Molecular Cancer Research. 18:B26-B26
Mutual exclusivity of RAS and BRAF mutations in multiple cancer types illustrates the key role of the RAF-MEK-ERK signaling pathway in mediating RAS oncogenesis. Although MEK inhibitors in particular are potent and specific, their on-target toxicity