A randomised phase II trial of temozolomide with or without cannabinoids in patients with recurrent glioblastoma (ARISTOCRAT): protocol for a multi-centre, double-blind, placebo-controlled trial

Autor: Divyalakshmi Bhaskaran, Joshua Savage, Amit Patel, Fiona Collinson, Rhys Mant, Florien Boele, Lucy Brazil, Sara Meade, Peter Buckle, Siân Lax, Lucinda Billingham, Susan C. Short

Publikováno v: BMC Cancer, Vol 24, Iss 1, Pp 1-12 (2024)

Abstract Background Glioblastoma (GBM) is the most common adult malignant brain tumour, with an incidence of 5 per 100,000 per year in England. Patients with tumours showing O6-methylguanine-DNA methyltransferase (MGMT) promoter methylation represent

Externí odkaz: https://doaj.org/article/eab0ef4f27614cabaf65f9eab32b4134

Overcoming challenges of translating deep-learning models for glioblastoma:the ZGBM consortium

Autor: Haris, Shuaib, Gareth J, Barker, Peter, Sasieni, Enrico, De Vita, Alysha, Chelliah, Roman, Andrei, Keyoumars, Ashkan, Erica, Beaumont, Lucy, Brazil, Chris, Rowland-Hill, Andrea, Lau, Aysha, Luis, James, Powell, Angela, Swampillai, Sean, Tenant, Stefanie C, Thust, Stephen, Wastling, Tom, Young, Thomas Calvert, Booth, Juliet, Brock, Stuart, Currie, Kavi, Fatani, Karen, Foweraker, Jennifer, Glendenning, Nigel, Hoggard, Avinash K, Kanodia, Anant, Krishnan, Mark Dv, Thurston, Joanne, Lewis, Christian, Linares, Ryan K, Mathew, Satheesh, Ramalingam, Vijay, Sawlani, Liam, Welsh, Matt, Williams

Publikováno v: 2023, ' Overcoming challenges of translating deep-learning models for glioblastoma : the ZGBM consortium ', British Journal of Radiology, vol. 96, no. 1141, 20220206 . https://doi.org/10.1259/bjr.20220206

Objective: To report imaging protocol and scheduling variance in routine care of glioblastoma patients in order to demonstrate challenges of integrating deep-learning models in glioblastoma care pathways. Additionally, to understand the most common i

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::078c27d90ee71a46d3adbece1c6ced86
https://kclpure.kcl.ac.uk/en/publications/8dda2016-a664-4344-abb6-fc7375793ea0

Trabectedin for recurrent WHO grade 2 or 3 meningioma: A randomized phase II study of the EORTC Brain Tumor Group (EORTC-1320-BTG)

Autor: Charlotte Bronnimann, Antonio Silvani, Vassilis Golfinopoulos, François Ducray, Martin Bendszus, Michael Weller, Marc Sanson, Paul Clement, Felix Sahm, Riccardo Soffietti, Niklas Thon, Corneel Coens, Florence Lefranc, Josef Pichler, Christian Mawrin, Veronique Lorgis, Lucy Brazil, Matthias Preusser, Emilie Le Rhun, Elodie Vauleon, Jacoline E C Bromberg, Alison Cameron, Juan Manuel Sepúlveda, Jordi Bruna, Joanne Lewis, Alice Bonneville-Levard, Christine Marosi, Sarah Dumont, Maximilian J. Mair, Sara Erridge, Julia Furtner, Jaap C. Reijneveld, Philipp Sievers, Wolfgang Wick, Giuseppe Lombardi, Petter Brandal, Carmen Balana, Thierry Gorlia

Publikováno v: Neuro-Oncology
r-IGTP. Repositorio Institucional de Producción Científica del Instituto de Investigación Germans Trias i Pujol
instname
Neuro Oncol
Preusser, M, Silvani, A, le Rhun, E, Soffietti, R, Lombardi, G, Sepulveda, J M, Brandal, P, Brazil, L, Bonneville-Levard, A, Lorgis, V, Vauleon, E, Bromberg, J, Erridge, S, Cameron, A, Lefranc, F, Clement, P M, Dumont, S, Sanson, M, Bronnimann, C, Balaná, C, Thon, N, Lewis, J, Mair, M J, Sievers, P, Furtner, J, Pichler, J, Bruna, J, Ducray, F, Reijneveld, J C, Mawrin, C, Bendszus, M, Marosi, C, Golfinopoulos, V, Coens, C, Gorlia, T, Weller, M, Sahm, F & Wick, W 2022, ' Trabectedin for recurrent WHO grade 2 or 3 meningioma : A randomized phase II study of the EORTC Brain Tumor Group (EORTC-1320-BTG) ', Neuro-Oncology, vol. 24, no. 5, pp. 755-767 . https://doi.org/10.1093/neuonc/noab243
Neuro-Oncology, 24(5), 755-767. Oxford University Press

Background No systemic treatment has been established for meningioma progressing after local therapies. Methods This randomized, multicenter, open-label, phase II study included adult patients with recurrent WHO grade 2 or 3 meningioma. Patients were

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::caa9ac3cf01f56f7912643d67ee32456
https://fundanet.igtp.cat/Publicaciones/ProdCientif/PublicacionFrw.aspx?id=4496

RADT-30. RADIATION INDUCED MENINGIOMA IN BACKGROUND OF CHILDHOOD CRANIAL IRRADIATION: A CASE SERIES

Autor: Sunnia Gupta, Angela Swampillai, Lucy Brazil, Omar Al-Salihi

Publikováno v: Neuro-Oncology. 24:vii56-vii56

BACKGROUND Cranial irradiation as part of prophylactic (PCI) or radical treatment for childhood malignancies can be associated with late consequences such as radiotherapy induced meningioma. METHODS We are reporting 5 such patients treated at our ins

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::bc76b3a10c8a91aed6ff6c97146ae906
https://doi.org/10.1093/neuonc/noac209.220

How Can Clinical Teams Support Patients With a Brain Tumour Diagnosis With Sex Relationships and Intimacy?

Autor: Ellie Kostick, Jessica La, Victoria Hurwitz, Sarah Hedges, Charlotte Robinson, Aeron Suarez, Keyoumars Ashkan, Ranjeev Bhangoo, Richard Gullan, Francesco Vergani, Lucy Brazil, Omar Al-Salihi, Angela Swampillai, Kazumi Chia, Katia Cikurel, Dorothy Joe, Gerald Finnerty, Jose Pedro Lavrador

Publikováno v: Neuro-Oncology. 24:iv13-iv13

AIMS There is a gap in supporting patients with sexual relationships and intimacy. The aim of this study is to establish if patients with a brain tumour feel they are able to ask questions and concerns about sex, relationships and intimacy following

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::3be9ed1125e666c077fcb6be4cf168b3
https://doi.org/10.1093/neuonc/noac200.056