Zobrazeno 1 - 10
of 53
pro vyhledávání: '"Lucy A. Hunsaker"'
Autor:
Lucy A. Hunsaker, Lorraine M. Deck, David L. Vander Jagt, Thomas A. Vander Jagt, Lisa J. Whalen, Robert E. Royer
Publikováno v:
European Journal of Medicinal Chemistry. 143:854-865
Inflammation and oxidative stress are common in many chronic diseases. Targeting signaling pathways that contribute to these conditions may have therapeutic potential. The transcription factor Nrf2 is a major regulator of phase II detoxification and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::283db546f09fcf027c5c7e0403000d37
https://doi.org/10.1016/j.ejmech.2017.11.048
https://doi.org/10.1016/j.ejmech.2017.11.048
Publikováno v:
Bioorganic & Medicinal Chemistry. 25:1423-1430
Nrf2, which is a member of the cap'n'collar family of transcription factors, is a major regulator of phase II detoxification and anti-oxidant genes as well as anti-inflammatory and neuroprotective genes. The importance of inflammation and oxidative s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cd95dd0fdc67d8a5e541031da39bb940
https://doi.org/10.1016/j.bmc.2017.01.005
https://doi.org/10.1016/j.bmc.2017.01.005
Autor:
Lorraine M. Deck, Tudor I. Oprea, Lucy A. Hunsaker, W. Michael Brown, Andrei Leitão, Donald R. Bellew, David L. Vander Jagt, Shawn Martin, Ariella Sasson
Publikováno v:
Journal of Chemical Information and Modeling. 48:1626-1637
Understanding the relationship between chemical structure and function is a ubiquitous problem within the fields of chemistry and biology. Simulation approaches attack the problem utilizing physics to understand a given process at the particle level.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ddd3b82233ee8a874c64f2df8d2f453d
https://doi.org/10.1021/ci8001233
https://doi.org/10.1021/ci8001233
Autor:
Justin J. Heynekamp, Thomas A. Vander Jagt, Robert E. Royer, Lorraine M. Deck, David L. Vander Jagt, Lucy A. Hunsaker
Publikováno v:
Bioorganic & Medicinal Chemistry. 16:5285-5294
Pancreatic cholesterol esterase (CEase), which is secreted from the exocrine pancreas, is a serine hydrolase that aids in the bile salt-dependent hydrolysis of dietary cholesteryl esters and contributes to the hydrolysis of triglycerides and phosphol
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9dc54d04fa67f03a2b300714769de045
https://doi.org/10.1016/j.bmc.2008.03.016
https://doi.org/10.1016/j.bmc.2008.03.016
Autor:
Lorraine M. Deck, Waylon M. Weber, Steve F. Abcouwer, David L. Vander Jagt, Robert E. Royer, Ekaterina V. Bobrovnikova-Marjon, C. Nathaniel Roybal, Lucy A. Hunsaker
Publikováno v:
Bioorganic & Medicinal Chemistry. 14:2450-2461
The transcription factor NFkappaB (NFkappaB) is up-regulated in many cancer cells where it contributes to development of the pro-survival, anti-apoptotic state. The natural product curcumin is a known inhibitor of activation of NFkappaB. Enone analog
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::07d543b1257b4ec66537ecbb19598525
https://doi.org/10.1016/j.bmc.2005.11.035
https://doi.org/10.1016/j.bmc.2005.11.035
Publikováno v:
Bioorganic & Medicinal Chemistry. 13:3811-3820
The natural product curcumin (diferuloylmethane, 1,7-bis(4-hydroxy-3-methoxyphenyl)-1,6-heptadiene-3,5-dione), obtained from the spice turmeric, exhibits numerous biological activities including anti-cancer, anti-inflammatory, and anti-angiogenesis a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::88fbf111eb5eaec8cdf15615eb4c20eb
https://doi.org/10.1016/j.bmc.2005.03.035
https://doi.org/10.1016/j.bmc.2005.03.035
Autor:
C. Nathaniel Roybal, Olena Barbash, Steve F. Abcouwer, Lucy A. Hunsaker, David L. Vander Jagt
Publikováno v:
Journal of Biological Chemistry. 280:20331-20339
Aberrant retinal expression of vascular endothelial growth factor (VEGF) leading to neovascularization is a central feature of age-related macular degeneration and diabetic retinopathy, two leading causes of vision loss. Oxidative stress is suggested
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d4ddddb561e0bc7b9b0687a0f7ed2f12
https://doi.org/10.1074/jbc.m411275200
https://doi.org/10.1074/jbc.m411275200
Autor:
M T Makler, Hoard A, Lorraine M. Deck, Vander Jagt Dl, Robert C. Piper, Yowell Ca, John B. Dame, Robert E. Royer, Vander Jagt Ta, William M. Brown, Lucy A. Hunsaker
Publikováno v:
Biochemistry. 43:6219-6229
Parasite lactate dehydrogenase (pLDH) is a potential drug target for new antimalarials owing to parasite dependence on glycolysis for ATP production. The pLDH from all four species of human malarial parasites were cloned, expressed, and analyzed for
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a436043e94170e190f7615f3a1714ca3
https://doi.org/10.1021/bi049892w
https://doi.org/10.1021/bi049892w
Autor:
William M. Brown, Lucy A. Hunsaker, David L. Vander Jagt, Jeremy P. Barlow, Louis E Metzger, Robert E. Royer, Lorraine M. Deck
Publikováno v:
Chemico-Biological Interactions. :481-491
17-beta-Hydroxysteroid dehydrogenase type 1 (17betaHSD1), also called estradiol dehydrogenase, catalyzes the NADPH-dependent reduction of the weak estrogen, estrone, into the more potent estrogen, 17-beta-estradiol. 17betaHSD1 is an attractive drug t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a667cc699ba5f4f90d2100d14041adb9
https://doi.org/10.1016/s0009-2797(02)00184-9
https://doi.org/10.1016/s0009-2797(02)00184-9
Autor:
David L. Vander Jagt, Robert E. Royer, Lorraine M. Deck, Xiulan Zhou, Caroline Dando, Eric R Schroeder, Stephen F. Parmley, Lucy A. Hunsaker
Publikováno v:
Molecular and Biochemical Parasitology. 118:23-32
Toxoplasma gondii differentially expresses two forms of lactate dehydrogenase in tachyzoites and bradyzoites, respectively, designated LDH1 and LDH2. Previously it was demonstrated that LDH1 and LDH2 share a unique structural feature with LDH from th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f22298750e451c891a5bbd26c746f966
https://doi.org/10.1016/s0166-6851(01)00360-7
https://doi.org/10.1016/s0166-6851(01)00360-7