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Synergistic Effect of 5-Hydroxytryptamine 3 and Neurokinin 1 Receptor Antagonism in Rodent Models of Somatic and Visceral Pain

Autor: Karl R. Tyler, Anthony H. Dickenson, Claudio Pietra, Lucy A. Bee, Ehsan Mohammadi, Beverley Greenwood-Van Meerveld

Publikováno v: Journal of Pharmacology and Experimental Therapeutics. 351:146-152

Synergistic activity has been observed between serotonergic 5-hydroxytryptamine 3 (5-HT3) and tachykinergic neurokinin 1 (NK1) receptor-mediated responses. This study investigated the efficacy of a 5-HT3 antagonist, palonosetron, and a NK1 antagonist

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a4937709f55b2c61af458df0e6014f8b
https://doi.org/10.1124/jpet.114.216028

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A pronociceptive role for the 5-HT2 receptor on spinal nociceptive transmission: An in vivo electrophysiological study in the rat

Autor: Wahida Rahman, Lucy A. Bee, Kirsty Bannister, Anthony H. Dickenson

Publikováno v: Brain Research

Serotonin (5-HT) plays a major yet complex role in modulating spinal nociceptive transmission as a consequence of the number of 5-HT receptor subtypes. These include the 5-HT2 receptor, which is further sub classified into 5-HT2A, B and C. Studies ha

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e67b1ef5a33566129768691ce03e0206
https://doi.org/10.1016/j.brainres.2011.01.057

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Effects of lacosamide, a novel sodium channel modulator, on dorsal horn neuronal responses in a rat model of neuropathy

Autor: Anthony H. Dickenson, Lucy A. Bee

Publikováno v: Neuropharmacology. 57:472-479

Various mechanisms underlie the complexity of neuropathic pain (pain due to disease of the somatosensory system), with each mechanism bearing a different order of relevance from one person and pain state to the next. Successful treatment is contingen

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::67ebce81bd6230ae3913fc6fb19307b4
https://doi.org/10.1016/j.neuropharm.2009.06.021

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Descending facilitation from the brainstem determines behavioural and neuronal hypersensitivity following nerve injury and efficacy of pregabalin

Autor: Lucy A. Bee, Anthony H. Dickenson

Publikováno v: Pain. 140:209-223

Various mechanisms at peripheral, spinal and/or supraspinal levels may underlie neuropathic pain. The nervous system's capacity for long-term reorganisation and chronic pain may result from abnormalities in RVM facilitatory On cells. Hence, via brain

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7b6418441ba711caaaae6954663a276d
https://doi.org/10.1016/j.pain.2008.08.008

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The Cav2.3 calcium channel antagonist SNX-482 reduces dorsal horn neuronal responses in a rat model of chronic neuropathic pain

Autor: Elizabeth A. Matthews, Anthony H. Dickenson, Gary J. Stephens, Lucy A. Bee

Publikováno v: European Journal of Neuroscience. 25:3561-3569

Neuropathic pain is a difficult state to treat, characterized by alterations in sensory processing that can include allodynia (touch-evoked pain). Evidence exists for nerve damage-induced plasticity in both transmission and modulatory systems, includ

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ef557e5e16ec0d998b13269e34c8fa2c
https://doi.org/10.1111/j.1460-9568.2007.05605.x

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Efficacy of Chronic Morphine in a Rat Model of Cancer-Induced Bone Pain: Behavior and in Dorsal Horn Pathophysiology

Autor: Tansy Donovan-Rodriguez, Catherine E. Urch, Anthony H. Dickenson, Richard Gordon-Williams, Lucy A. Bee

Publikováno v: The Journal of Pain. 6:837-845

Morphine is one of the main analgesics in cancer-induced bone pain (CIBP). To investigate the efficacy of morphine in CIBP and alteration in dorsal horn pathophysiology, systemic morphine was administered (3 mg/kg) bi-daily between days 11 and 15 aft

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7af9992c552d4fc907ad0739ee27a48d
https://doi.org/10.1016/j.jpain.2005.08.005

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A role for Piezo2 in EPAC1-dependent mechanical allodynia

Autor: Uhtaek Oh, James J. Cox, John E. Linley, J. M. Torres, M. Gringhuis, G. S. Hong, John N. Wood, F. J. Zwartkuis, Anthony H. Dickenson, Yoshihiro Ishikawa, Michael S. Minett, Lucy A. Bee, E. Lee, Niels Eijkelkamp

Publikováno v: Digibug. Repositorio Institucional de la Universidad de Granada
instname
Nature Communications
Digibug: Repositorio Institucional de la Universidad de Granada
Universidad de Granada (UGR)

N.E. and J.W. designed and supervised experiments. N.E. performed most of the in vivo and in vitro experiments. J.L. performed experiments to characterize hPiezo2. G.H and G.L. supervised by U.O., and J.T. and J.C. cloned hPiezo. L.B. performed the i

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6480563fade9371f99ef77d7e0718a36
http://hdl.handle.net/10481/64046

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Small RNAs Control Sodium Channel Expression, Nociceptor Excitability, and Pain Thresholds

Autor: Anthony H. Dickenson, Matthias Merkenschlager, Curtis O. Asante, Bradly S. Cobb, Jing Zhao, John N. Wood, James R. Perkins, Aliakmal Momin, Cruz-Miguel Cendan, Mohammed A. Nassar, Lucy A. Bee, Bjarke Abrahamsen, Samuel T. Shepherd, Man-Cheung Lee, Audrey Bethry, Mark D. Baker

To examine the role of small RNAs in peripheral pain pathways, we deleted the enzyme Dicer in mouse postmitotic damage-sensing neurons. We used a Nav1.8-Cre mouse to target those nociceptors important for inflammatory pain. The conditional null mice

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::36e398f62500c1feaa0dd7326a0f1721
https://europepmc.org/articles/PMC6634685/

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Mu-opioid and noradrenergic α(2)-adrenoceptor contributions to the effects of tapentadol on spinal electrophysiological measures of nociception in nerve-injured rats

Autor: Lucy A. Bee, Anthony H. Dickenson, Wahida Rahman, Kirsty Bannister

Publikováno v: PainReferences. 152(1)

Multiple pathological mechanisms at multiple sensory sites may underlie the pain that follows nerve injury. This provides a basis for recommending more than one agent, either sequentially or in combination, for its treatment. According to this premis

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c2ff52903485f3a98be36a63bd03cb83
https://pubmed.ncbi.nlm.nih.gov/21187272

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The importance of the descending monoamine system for the pain experience and its treatment

Autor: Lucy A. Bee, Anthony H. Dickenson

Publikováno v: F1000 Medicine Reports

Brainstem and midbrain areas engage descending facilitatory and inhibitory neurones to potentiate or suppress the passage of sensory inputs from spinal loci to the brain. The balance between descending controls, both excitatory and inhibitory, can be

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::324f8510868475b455e638e07cd45ae4
http://europepmc.org/articles/PMC2948332

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