Zobrazeno 1 - 10
of 51
pro vyhledávání: '"Lucy A Coupland"'
Autor:
Lucy A. Coupland, David J. Rabbolini, Jonathan G. Schoenecker, Philip J. Crispin, Jennene J. Miller, Tony Ghent, Robert L. Medcalf, Anders E. Aneman
Publikováno v:
Critical Care, Vol 27, Iss 1, Pp 1-14 (2023)
Abstract Background Fibrinolysisis is essential for vascular blood flow maintenance and is triggered by endothelial and platelet release of tissue plasminogen activator (t-PA). In certain critical conditions, e.g. sepsis, acute respiratory failure (A
Externí odkaz:
https://doaj.org/article/1ced2b4de044430591df027ad12967a8
Publikováno v:
eJHaem, Vol 3, Iss 1, Pp 80-85 (2022)
Abstract Platelet transfusions are not always available for bleeding in severe thrombocytopenia, as storage outside of major centers is limited by their short shelf‐life. Data are lacking to support alternative available blood products; however, ad
Externí odkaz:
https://doaj.org/article/296dada9878f487495f714d2b825c4fa
Publikováno v:
Platelets, Vol 32, Iss 5, Pp 662-670 (2021)
The ability of platelets to promote carcinoma and melanoma progression has been thoroughly studied and occurs in numerous ways. In contrast, the effect of platelets on sarcomas, tumors arising from mesenchymal cells, has received very little attentio
Externí odkaz:
https://doaj.org/article/7de76586a59641d38724f375ebd59f66
Autor:
Chang-Won Kang, Anneke C. Blackburn, Amos Hong Pheng Loh, Kuick Chick Hong, Jian Yuan Goh, Nadine Hein, Denis Drygin, Chris R. Parish, Ross D. Hannan, Katherine M. Hannan, Lucy A. Coupland
Publikováno v:
Biomedicines, Vol 11, Iss 4, p 1133 (2023)
The survival rate of patients with osteosarcoma (OS) has not improved over the last 30 years. Mutations in the genes TP53, RB1 and c-Myc frequently occur in OS and enhance RNA Polymerase I (Pol I) activity, thus supporting uncontrolled cancer cell pr
Externí odkaz:
https://doaj.org/article/828e24308c6e4101a33cd536ee4eaae4
Autor:
Connor H. O’ Meara, Lucy A. Coupland, Farzaneh Kordbacheh, Benjamin J. C. Quah, Chih-Wei Chang, David A. Simon Davis, Anna Bezos, Anna M. Browne, Craig Freeman, Dillon J. Hammill, Pradeep Chopra, Gergely Pipa, Paul D. Madge, Esther Gallant, Courtney Segovis, Angela F. Dulhunty, Leonard F. Arnolda, Imogen Mitchell, Levon M. Khachigian, Ross W. Stephens, Mark von Itzstein, Christopher R. Parish
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-17 (2020)
Histones, proteins that bind DNA, are toxic for pathogens outside cells but can also cause multi-organ damage as seen in sepsis. Here the authors develop small negatively charged molecules that can be used as histone antidotes, and show that they imp
Externí odkaz:
https://doaj.org/article/47652de3a653433fb4ea511fb90437ea
Publikováno v:
Platelets, Vol 31, Iss 3, Pp 315-321 (2020)
Diagnosis of immune thrombocytopenia (ITP) and prediction of response to therapy remain significant and constant challenges in hematology. In patients who present with ITP, the platelet count is frequently used as a surrogate marker for disease sever
Externí odkaz:
https://doaj.org/article/d924fb3f542846a5b5a182d3ebed21e9
Autor:
Sarah K. Popp, Federica Vecchio, Debra J. Brown, Riho Fukuda, Yuri Suzuki, Yuma Takeda, Rikako Wakamatsu, Mahalakshmi A. Sarma, Jessica Garrett, Anna Giovenzana, Emanuele Bosi, Antony R.A. Lafferty, Karen J. Brown, Elizabeth E. Gardiner, Lucy A. Coupland, Helen E. Thomas, Beng H. Chong, Christopher R. Parish, Manuela Battaglia, Alessandra Petrelli, Charmaine J. Simeonovic
Publikováno v:
JCI Insight, Vol 7, Iss 2 (2022)
Platelet-neutrophil aggregates (PNAs) facilitate neutrophil activation and migration and could underpin the recruitment of neutrophils to the pancreas during type 1 diabetes (T1D) pathogenesis. PNAs, measured by flow cytometry, were significantly ele
Externí odkaz:
https://doaj.org/article/6ed7806b9e764fde908116c406bf2ddb
Autor:
Dan Dan Tian, Samuel K. Bennett, Lucy A. Coupland, Kathryn Forwood, Yadanar Lwin, Niloofar Pooryousef, Illa Tea, Thy T. Truong, Teresa Neeman, Philip Crispin, James D’Rozario, Anneke C. Blackburn
Publikováno v:
Pharmacology Research & Perspectives, Vol 7, Iss 6, Pp n/a-n/a (2019)
Abstract Dichloroacetate (DCA) is an investigational drug targeting the glycolytic hallmark of cancer by inhibiting pyruvate dehydrogenase kinases (PDK). It is metabolized by GSTZ1, which has common polymorphisms altering enzyme or promoter activity.
Externí odkaz:
https://doaj.org/article/bc581c67dbd04d46abbcf7e34da22e4d
Autor:
James H. O’Connor, Hayley A. McNamara, Yeping Cai, Lucy A. Coupland, Elizabeth E. Gardiner, Christopher R. Parish, Brendan J. McMorran, Vitaly V. Ganusov, Ian A. Cockburn
Publikováno v:
The Journal of Immunology. 208:2738-2748
Liver-resident CD8+ T cells can play critical roles in the control of pathogens, including Plasmodium and hepatitis B virus. Paradoxically, it has also been proposed that the liver may act as the main place for the elimination of CD8+ T cells at the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::95401ea3e82160a25570fcbba69009d3
https://doi.org/10.4049/jimmunol.2101037
https://doi.org/10.4049/jimmunol.2101037
PDF file, 430K, 4T1.2 subcutaneous tumor growth in platelet-deficient mice.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::85b520c1b3f8738f6411bf9e6e6adfcf
https://doi.org/10.1158/0008-5472.22392000
https://doi.org/10.1158/0008-5472.22392000
