Zobrazeno 1 - 10
of 249
pro vyhledávání: '"Lucy, Dorrell"'
Autor:
Gavuthami Murugesan, Rachel L. Paterson, Rakesh Kulkarni, Veronica Ilkow, Richard J. Suckling, Mary M. Connolly, Vijaykumar Karuppiah, Robert Pengelly, Archana Jadhav, Jose Donoso, Tiaan Heunis, Wilawan Bunjobpol, Gwilym Philips, Kafayat Ololade, Daniel Kay, Anshuk Sarkar, Claire Barber, Ritu Raj, Carole Perot, Tressan Grant, Agatha Treveil, Andrew Walker, Marcin Dembek, Dawn Gibbs-Howe, Miriam Hock, Ricardo J. Carreira, Kate E. Atkin, Lucy Dorrell, Andrew Knox, Sarah Leonard, Mariolina Salio, Luis F. Godinho
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-15 (2024)
Abstract The non-polymorphic HLA-E molecule offers opportunities for new universal immunotherapeutic approaches to chronic infectious diseases. Chronic Hepatitis B virus (HBV) infection is driven in part by T cell dysfunction due to elevated levels o
Externí odkaz:
https://doaj.org/article/3dc727caf8474340a5e4d1bb478f8c46
Autor:
Jakub Kopycinski, Hongbing Yang, Gemma Hancock, Matthew Pace, Ellen Kim, John Frater, Wolfgang Stöhr, Tomás Hanke, Sarah Fidler, Lucy Dorrell, RIVER trial study group
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-10 (2023)
Abstract ‘Kick and kill’ cure strategies aim to induce HIV protein expression in latently infected cells (kick), and thus trigger their elimination by cytolytic T cells (kill). In the Research in Viral Eradication of HIV Reservoirs trial (NCT0233
Externí odkaz:
https://doaj.org/article/19593e2c5fbc4f9091240b09b4c2b090
Autor:
Zoë Wallace, Jakub Kopycinski, Hongbing Yang, Michelle L. McCully, Christian Eggeling, Jakub Chojnacki, Lucy Dorrell
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-13 (2022)
Abstract T cell exhaustion develops in human immunodeficiency virus (HIV) infection due to chronic viral antigenic stimulation. This adaptive response primarily affects virus-specific CD8+ T cells, which may remain dysfunctional despite viral load-re
Externí odkaz:
https://doaj.org/article/fdde8440cb184babaf7c956ef964feda
Autor:
Xu Peng, Isaac Woodhouse, Gemma Hancock, Robert Parker, Kristina Marx, Julius Müller, Silvia Salatino, Thomas Partridge, Annalisa Nicastri, Hanqing Liao, Gary Kruppa, Karin Hellner, Lucy Dorrell, Nicola Ternette
Publikováno v:
iScience, Vol 26, Iss 3, Pp 106101- (2023)
Summary: Current immunotherapeutic approaches for human papillomavirus (HPV)-driven cervical cancer target the viral oncogenes E6 and E7. We report viral canonical and alternative reading frame (ARF)-derived sequences presented on cervical tumor cell
Externí odkaz:
https://doaj.org/article/7a2d88fc08a94b27b6d93df3c7c3919a
Autor:
Aljawharah Alrubayyi, Ester Gea-Mallorquí, Emma Touizer, Dan Hameiri-Bowen, Jakub Kopycinski, Bethany Charlton, Natasha Fisher-Pearson, Luke Muir, Annachiara Rosa, Chloe Roustan, Christopher Earl, Peter Cherepanov, Pierre Pellegrino, Laura Waters, Fiona Burns, Sabine Kinloch, Tao Dong, Lucy Dorrell, Sarah Rowland-Jones, Laura E. McCoy, Dimitra Peppa
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-16 (2021)
Understanding the pathology and immunological response to SARS CoV2 infection in specific patient groups is essential for informing the scientific and clinical handling of infections within these patient populations. Here the authors characterise the
Externí odkaz:
https://doaj.org/article/de4813a9861e43bab28f9f0beeed1ff5
Autor:
Elena Woods, Vanessa Zaiatz-Bittencourt, Ciaran Bannan, Colm Bergin, David K. Finlay, Matthias Hoffmann, Anthony Brown, Bethany Turner, Shokouh Makvandi-Nejad, Ventzi Vassilev, Stefania Capone, Antonella Folgori, Tomáš Hanke, Eleanor Barnes, Lucy Dorrell, Clair M. Gardiner, PEACHI Consortium
Publikováno v:
npj Vaccines, Vol 6, Iss 1, Pp 1-9 (2021)
Abstract Effective vaccines for human immunodeficiency virus-1 (HIV-1) and hepatitis C virus (HCV) remain a significant challenge for these infectious diseases. Given that the innate immune response is key to controlling the scale and nature of devel
Externí odkaz:
https://doaj.org/article/74d0067fe0754a63bf1b9631ac60ca73
Publikováno v:
Journal of Virus Eradication, Vol 8, Iss 3, Pp 100082- (2022)
Immunotherapeutic interventions to enhance natural HIV-specific CD8+ T cell responses, such as vaccination or adoptive T cell transfer, have been a major focus of HIV cure efforts. However, these approaches have not been effective in overcoming viral
Externí odkaz:
https://doaj.org/article/84796e9aac354731ad2b236809f06c47
Autor:
Jasmini Alagaratnam, Wolfgang Stöhr, Jamie Toombs, Amanda Heslegrave, Henrik Zetterberg, Magnus Gisslén, Sarah Pett, Mark Nelson, Amanda Clarke, Nneka Nwokolo, Margaret A. Johnson, Maryam Khan, Tomas Hanke, Jakub Kopycinski, Lucy Dorrell, Julie Fox, Sabine Kinloch, Jonathan Underwood, Matthew Pace, John Frater, Alan Winston, Sarah Fidler
Publikováno v:
Journal of Virus Eradication, Vol 7, Iss 3, Pp 100056- (2021)
Objective: HIV-remission strategies including kick-and-kill could induce viral transcription and immune-activation in the central nervous system, potentially causing neuronal injury. We investigated the impact of kick-and-kill on plasma neurofilament
Externí odkaz:
https://doaj.org/article/e67c8ca158464981987f7ea91b16fef1
Autor:
Beatriz Mothe, Christian Manzardo, Alvaro Sanchez-Bernabeu, Pep Coll, Sara Morón-López, Maria C. Puertas, Miriam Rosas-Umbert, Patricia Cobarsi, Roser Escrig, Núria Perez-Alvarez, Irene Ruiz, Cristina Rovira, Michael Meulbroek, Alison Crook, Nicola Borthwick, Edmund G. Wee, Hongbing Yang, Jose M. Miró, Lucy Dorrell, Bonaventura Clotet, Javier Martinez-Picado, Christian Brander, Tomáš Hanke
Publikováno v:
EClinicalMedicine, Vol 11, Iss , Pp 65-80 (2019)
Background: Strong and broad antiviral T-cell responses targeting vulnerable sites of HIV-1 will likely be a critical component for any effective cure strategy. Methods: BCN01 trial was a phase I, open-label, non-randomized, multicenter study in HIV-
Externí odkaz:
https://doaj.org/article/9525071b69b242ee8ae52281b8baa3b5
Autor:
Beatriz Mothe, Christian Manzardo, Alvaro Sanchez-Bernabeu, Pep Coll, Sara Morón-López, Maria C. Puertas, Miriam Rosas-Umbert, Patricia Cobarsi, Roser Escrig, Núria Perez-Alvarez, Irene Ruiz, Cristina Rovira, Michael Meulbroek, Alison Crook, Nicola Borthwick, Edmund G. Wee, Hongbing Yang, Jose M. Miró, Lucy Dorrell, Bonaventura Clotet, Javier Martinez-Picado, Christian Brander, Tomáš Hanke
Publikováno v:
EClinicalMedicine, Vol 18, Iss , Pp - (2020)
Externí odkaz:
https://doaj.org/article/a4f263379a7040ce9f20a42570c6a9c7