Abscisic Acid and Its Receptors LANCL1 and LANCL2 Control Cardiomyocyte Mitochondrial Function, Expression of Contractile, Cytoskeletal and Ion Channel Proteins and Cell Proliferation via ERRα

Autor: Sonia Spinelli, Lucrezia Guida, Mario Passalacqua, Mirko Magnone, Vanessa Cossu, Gianmario Sambuceti, Cecilia Marini, Laura Sturla, Elena Zocchi

Publikováno v: Antioxidants, Vol 12, Iss 9, p 1692 (2023)

The cross-kingdom stress hormone abscisic acid (ABA) and its mammalian receptors LANCL1 and LANCL2 regulate the response of cardiomyocytes to hypoxia by activating NO generation. The overexpression of LANCL1/2 increases transcription, phosphorylation

Externí odkaz: https://doaj.org/article/4dc2e87cc10b4478ab8cb3949999c275

The ABA-LANCL1/2 Hormone-Receptors System Protects H9c2 Cardiomyocytes from Hypoxia-Induced Mitochondrial Injury via an AMPK- and NO-Mediated Mechanism

Autor: Sonia Spinelli, Lucrezia Guida, Tiziana Vigliarolo, Mario Passalacqua, Giulia Begani, Mirko Magnone, Laura Sturla, Andrea Benzi, Pietro Ameri, Edoardo Lazzarini, Claudia Bearzi, Roberto Rizzi, Elena Zocchi

Publikováno v: Cells, Vol 11, Iss 18, p 2888 (2022)

Abscisic acid (ABA) regulates plant responses to stress, partly via NO. In mammals, ABA stimulates NO production by innate immune cells and keratinocytes, glucose uptake and mitochondrial respiration by skeletal myocytes and improves blood glucose ho

Externí odkaz: https://doaj.org/article/39205a5ca85e461aaf0422197f1a9c37

Abscisic Acid Improves Insulin Action on Glycemia in Insulin-Deficient Mouse Models of Type 1 Diabetes

Autor: Mirko Magnone, Sonia Spinelli, Giulia Begani, Lucrezia Guida, Laura Sturla, Laura Emionite, Elena Zocchi

Publikováno v: Metabolites, Vol 12, Iss 6, p 523 (2022)

Abscisic acid (ABA), a plant hormone, has recently been shown to play a role in glycemia regulation in mammals, by stimulating insulin-independent glucose uptake and metabolism in skeletal muscle. The aim of this study was to test whether ABA could i

Externí odkaz: https://doaj.org/article/6598846275ba467893ed43b42e8488fd

The ABA/LANCL Hormone/Receptor System in the Control of Glycemia, of Cardiomyocyte Energy Metabolism, and in Neuroprotection: A New Ally in the Treatment of Diabetes Mellitus?

Autor: Sonia Spinelli, Mirko Magnone, Lucrezia Guida, Laura Sturla, Elena Zocchi

Publikováno v: International Journal of Molecular Sciences. 24:1199

Abscisic acid (ABA), long known as a plant stress hormone, is present and functionally active in organisms other than those pertaining to the land plant kingdom, including cyanobacteria, fungi, algae, protozoan parasites, lower Metazoa, and mammals.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::846cda2e63e1d162078a256a03d02266
https://doi.org/10.3390/ijms24021199

Insulin-independent stimulation of skeletal muscle glucose uptake by low-dose abscisic acid via AMPK activation

Autor: Mirko Magnone 1, 2, Laura Emionite 3, Lucrezia Guida 1, Tiziana Vigliarolo 1, Laura Sturla 1, Sonia Spinelli 1, Ambra Buschiazzo 4, Cecilia Marini 4, 5, 6, Gianmario Sambuceti 4, Antonio De Flora 1, Anna Maria Orengo 4, Vanessa Cossu 4, Sara Ferrando 7, Ottavia Barbieri 3, Elena Zocchi 1.

Publikováno v: Scientific reports (Nature Publishing Group) 10 (2020): 1454. doi:10.1038/s41598-020-58206-0
info:cnr-pdr/source/autori:Mirko Magnone 1,2, Laura Emionite 3, Lucrezia Guida 1, Tiziana Vigliarolo 1, Laura Sturla 1, Sonia Spinelli 1, Ambra Buschiazzo 4, Cecilia Marini 4,5,6, Gianmario Sambuceti 4,5,6, Antonio De Flora 1, Anna Maria Orengo 4, Vanessa Cossu 4, Sara Ferrando 7, Ottavia Barbieri 3, Elena Zocchi 1./titolo:Insulin-independent stimulation of skeletal muscle glucose uptake by low-dose abscisic acid via AMPK activation./doi:10.1038%2Fs41598-020-58206-0/rivista:Scientific reports (Nature Publishing Group)/anno:2020/pagina_da:1454/pagina_a:/intervallo_pagine:1454/volume:10
Scientific Reports, Vol 10, Iss 1, Pp 1-14 (2020)
Scientific Reports

Abscisic acid (ABA) is a plant hormone active also in mammals where it regulates, at nanomolar concentrations, blood glucose homeostasis. Here we investigated the mechanism through which low-dose ABA controls glycemia and glucose fate. ABA stimulated

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b764d313b39e82d9d78c7570bef374ae
http://www.cnr.it/prodotto/i/416488