Zobrazeno 1 - 7 of 7 pro vyhledávání: '"Lucrezia Della Volpe"'
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Akademický článek
A millifluidic bioreactor allows the long term culture of primary lymphocytes or CD34+ hematopoietic cells while allowing the detection of tumorigenic expansion
Autor: Paolo Ritter, Stefania Oliveto, Chiara Cordiglieri, Alessandra Fasciani, Christian Andrea Di Buduo, Lucrezia della Volpe, Alberto Bocconi, Claudio Conci, Carolina Paula Miguel, Raffaella Di Micco, Alessandra Balduini, Manuela Teresa Raimondi, Stefano Biffo
Publikováno v: Frontiers in Bioengineering and Biotechnology, Vol 12 (2024)
Long-term culture of primary lymphocytes and hematopoietic stem and progenitor cells (HSPCs) is pivotal to their expansion and study. Furthermore, genetic engineering of the above-mentioned primary human cells has several safety needs, including the
Externí odkaz: https://doaj.org/article/fbb1b54cf71244f7bd26fbbeaf6a7fce
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2
DNA damage contributes to neurotoxic inflammation in Aicardi-Goutières Syndrome astrocytes
Autor: Anna Maria Sole Giordano, Marco Luciani, Francesca Gatto, Monah Abou Alezz, Chiara Beghè, Lucrezia Della Volpe, Alessandro Migliara, Sara Valsoni, Marco Genua, Monika Dzieciatkowska, Giacomo Frati, Julie Tahraoui-Bories, Silvia Clara Giliani, Simona Orcesi, Elisa Fazzi, Renato Ostuni, Angelo D’Alessandro, Raffaella Di Micco, Ivan Merelli, Angelo Lombardo, Martin A.M. Reijns, Natalia Gromak, Angela Gritti, Anna Kajaste-Rudnitski
Publikováno v: Giordano, A M S, Luciani, M, Gatto, F, Alezz, M A, Beghè, C, Volpe, L D, Migliara, A, Valsoni, S, Genua, M, Dzieciatkowska, M, Frati, G, Tahraoui-Bories, J, Giliani, S, Orcesi, S, Fazzi, E, Ostuni, R, D'Alessandro, A, Di Micco, R, Merelli, I, Lombardo, A, Reijns, M A M, Gromak, N, Gritti, A & Kajaste-Rudnitski, A 2022, ' DNA damage contributes to neurotoxic inflammation in Aicardi-Goutières Syndrome astrocytes ', Journal of Experimental Medicine . https://doi.org/10.1084/jem.20211121
Aberrant induction of type I IFN is a hallmark of the inherited encephalopathy Aicardi-Goutières syndrome (AGS), but the mechanisms triggering disease in the human central nervous system (CNS) remain elusive. Here, we generated human models of AGS u
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b6ef1e584c11350bd68e39734f6e497a
https://hdl.handle.net/20.500.11820/f905c0ad-a583-41ee-b773-ef3151aa32fa
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3
Human iPSC-based neurodevelopmental models of globoid cell leukodystrophy uncover patient- and cell type-specific disease phenotypes
Autor: Angela Bachi, Elisabeth Mangiameli, Vittoria Matafora, Angela Pesenti Gritti, Lucrezia della Volpe, Lucia Susani, Daniela Gnani, Marianna Paulis, Francesca Sanvito, Sabata Martino, Anna Cecchele, Raffaella Di Micco, Francesco Morena, Angela Cattaneo
Publikováno v: Stem Cell Reports
Summary Globoid cell leukodystrophy (GLD) is a rare neurodegenerative lysosomal storage disease caused by an inherited deficiency of β-galactocerebrosidase (GALC). GLD pathogenesis and therapeutic correction have been poorly studied in patient neura
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5d521efd1a81132c0771462c4fa48f1a
https://pubmed.ncbi.nlm.nih.gov/33989519
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5
Differential phosphorylation-based regulation of αB-crystallin chaperone activity for multipass transmembrane proteins
Autor: Simona Allocca, Michela Ciano, Lucrezia della Volpe, Maria Camilla Ciardulli, Stefano Bonatti, Massimo D'Agostino
Publikováno v: Biochemical and Biophysical Research Communications
We have previously shown that αB-crystallin (CRYAB), a small heat shock protein (sHsp) that prevents irreversible aggregation of unfolded protein by an ATP-independent chaperone activity, plays a pivotal role in the biogenesis of multipass transmemb
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::310f60f8fb9199ccdedeb79ead4d2fc0
https://doi.org/10.1016/j.bbrc.2016.09.071
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6
Precise Gene Editing Preserves Hematopoietic Stem Cell Function following Transient p53-Mediated DNA Damage Response
Autor: Raffaella Di Micco, Giulia Schiroli, Valentina Vavassori, Anastasia Conti, Pietro Genovese, Delphine Ndiaye-Lobry, Patrizia Gasparini, Julie Chaumeil, Chiara Brombin, Lucrezia della Volpe, Ivan Merelli, Aurelien Jacob, Eugenio Montini, Andrea Calabria, Samuele Ferrari, Luigi Naldini, Stefano Beretta, Luisa Albano, Eralda Salataj
Publikováno v: Cell stem cell
(2019). doi:10.1016/j.stem.2019.02.019
info:cnr-pdr/source/autori:Schiroli G, Conti A, Ferrari S, Della Volpe L, Jacob A, Albano L, Beretta S, Calabria A, Vavassori V, Gasparini P, Salataj E, Ndiaye-Lobry D, Brombin C, Chaumeil J, Montini E, Merelli I, Genovese P, Naldini L, Di Micco R./titolo:Precise Gene Editing Preserves Hematopoietic Stem Cell Function following Transient p53-Mediated DNA Damage Response/doi:10.1016%2Fj.stem.2019.02.019/rivista:Cell stem cell (Print)/anno:2019/pagina_da:/pagina_a:/intervallo_pagine:/volume
Precise gene editing in hematopoietic stem and progenitor cells (HSPCs) holds promise for treating genetic diseases. However, responses triggered by programmable nucleases in HSPCs are poorly characterized and may negatively impact HSPC engraftment a
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::26e2c115a7ee7581180ef11317f7beb1
https://doi.org/10.1016/j.stem.2019.02.019
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