Výsledky vyhledávání - "Lucrecia Campayo"

Acid–base behaviour and binding to double stranded DNA/RNA of benzo[g]phthalazine-based ligands

Autor: Eudald Carbonell, Roberto Tejero, María J. R. Yunta, Enrique García-España, Lucrecia Campayo, Fernando Gómez-Contreras, Mercedes Cano, Cristina Galiana-Roselló, Álvaro Martínez-Camarena, Ana M. Sanz, Mario Inclán, Jorge González-García, Pilar Navarro

Publikováno v: Digital.CSIC. Repositorio Institucional del CSIC
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The affinity and the binding mode of two benzo[g]phthalazine compounds, functionalized with one or two 2-(imidazole-4-yl)-ethylamine groups, to DNA and RNA models have been evaluated by means of UV-Vis, fluorescence and circular dichroism (CD) spectr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d9a5d40939b490030d28f37255ea4880
https://doi.org/10.1039/c8nj05039b

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In vitro Leishmanicidal and Trypanosomicidal Properties of Imidazole-Containing Azine and Benzoazine Derivatives

Autor: Manuel Sánchez-Moreno, Kristina Kolodova, Carmen Cano, María José Rosales-Lombardo, María J. R. Yunta, Lucrecia Campayo, Ana M. Sanz, Lucía de Andrés-Gordo, Álvaro Martín-Montes, Alberto Gómez-Muñoz, Clotilde Marín

Publikováno v: Digibug. Repositorio Institucional de la Universidad de Granada
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The authors thank the MCINN Project CTQ2009-14288-C04-01 for financial support. We are also grateful to the NMR and Elemental Analysis C.A.I.s of the Universidad Complutense (Madrid), and to the Transmission-electron microscopy and Nuclear magnetic r

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::51dde5bebf5e553275be304a8520de8d
http://hdl.handle.net/10481/71408

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Synthesis and evaluation of in vitro and in vivo trypanocidal properties of a new imidazole-containing nitrophthalazine derivative

Autor: María José Rosales, Carmen Cano, Manuel Sánchez-Moreno, Francisco Olmo, David Martín-Oliva, Pilar Navarro, Lucrecia Campayo, María J. R. Yunta, Fernando Gómez-Contreras, Clotilde Marín

Publikováno v: European journal of medicinal chemistry. 106

A series of new phthalazine derivatives (1-4) containing imidazole rings and functionalized with nitro groups in the benzene ring of the phthalazine moiety were prepared and identified on the basis of their MS, elemental analyses and bidimensional (1

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1c4b6bea5af84579c9c6fc460b54540c
https://pubmed.ncbi.nlm.nih.gov/26523668

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In vitro leishmanicidal activity of imidazole- or pyrazole-based benzo[g]phthalazine derivatives against leishmania infantum and leishmania braziliensis species

Autor: Francisco Olmo, María J. R. Yunta, Ana M. Sanz, Manuel Sánchez-Moreno, Inmaculada Ramírez-Macías, Fernando Gómez-Contreras, Clotilde Marín, Lucrecia Campayo, Carmen Cano, Pilar Navarro

Publikováno v: Digital.CSIC. Repositorio Institucional del CSIC
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Objectives: To evaluate the in vitro leishmanicidal activity of imidazole-based (1-4) and pyrazole-based (5-6) benzo[g]phthalazine derivatives against Leishmania infantum and Leishmania braziliensis. Methods: The in vitro activity of compounds 1-6 wa

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7430064d9880d9a6beec28a03babe7e9
http://hdl.handle.net/10261/121583

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Imidazole-containing phthalazine derivatives inhibit Fe-SOD performance in Leishmania species and are active in vitro against visceral and mucosal leishmaniasis

Autor: María J. R. Yunta, Manuel Sánchez-Moreno, Lucrecia Campayo, Inmaculada Ramírez-Macías, Carmen Cano, Ana M. Sanz, Clotilde Marín, Fernando Gómez-Contreras, María José Rosales, Pilar Navarro

Publikováno v: Digital.CSIC. Repositorio Institucional del CSIC
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The in vitro leishmanicidal activity of a series of imidazole-containing phthalazine derivatives 1-4 was tested on Leishmania infantum, Leishmania braziliensis and Leishmania donovani parasites, and their cytotoxicity on J774·2 macrophage cells was

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::37aba162579212d73bbf2272ba7c1930
http://hdl.handle.net/10261/117717

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A new series of heteroaromatic receptors containing the 1,3-bis(6-oxopyridazin-1-yl)propane unit: their selective transport ability towards NH4+ in relation to Na+, K+ and Ca2+

Autor: Ana Cotillas, Oscar Jaúregui, Fernando Gómez-Contreras, María J. R. Yunta, Carmen Cano, Mercedes Pardo, Pilar Navarro, Lucrecia Campayo, Ana M. Sanz

Publikováno v: Tetrahedron. 60:979-986

The synthesis of a new series of heteroaromatic macrocycles 6 – 9 containing the 1,3-bis(6-oxopyridazin-1-yl)propane and pyridine units is reported. The acyclic compounds 11 – 15 had to be prepared as the intermediates in the synthetic sequence.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::c4aa88498f3e579f9e6282c8aa143777
https://doi.org/10.1016/j.tet.2003.11.040

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A Proton-Ionizable Ester Crown of 3,5-Disubstituted 1H-Pyrazole Able To Form Stable Dinuclear Complexes with Lipophilic Phenethylamines

Autor: Jose M. Bueno, Jesús Jiménez-Barbero, Lucrecia Campayo, Gérard Pèpe, Pilar Navarro, Andre Samat, Carmen Ochoa

Publikováno v: The Journal of Organic Chemistry. 62:2684-2693

A convenient synthesis of the proton-ionizable crown 3 is reported that uses dibutyltin oxide. In acetonitrile, the reaction of 3 (LH(2)) with phenethylamine and homoveratrylamine (molar ratio 1:2) affords solid dinuclear complexes [LH(2)]2RNH(2) (4a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::228924892be54f29443d2db94d125dc9
https://doi.org/10.1021/jo9623651

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Phthalazine derivatives containing imidazole rings behave as Fe-SOD inhibitors and show remarkable anti-T. cruzi activity in immunodeficient-mouse mode of infection

Autor: Ana M. Sanz, Carmen Cano, Clotilde Marín, Manuel Sánchez-Moreno, Pilar Navarro, Francisco Olmo, Lucrecia Campayo, Fernando Gómez-Contreras, María José Rosales, María J. R. Yunta

Publikováno v: Journal of medicinal chemistry. 55(22)

A series of new phthalazine derivatives 1–4 containing imidazole rings were prepared. The monoalkylamino substituted derivatives 2 and 4 were more active in vitro against T. cruzi and less toxic against Vero cells than both their disubstituted anal

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::717b93d8860d4459e33f46d3e2f7d9f9
https://pubmed.ncbi.nlm.nih.gov/23043291

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The action of the DNA intercalating agents 4′-(9-acridinylamino) methanesulphon-m-anisidide and 1,4-bis(butylamino) benzo[G]phthalazine in U-937 human promonocytic cells: Relationship between cell cycle and differentiation

Autor: Concepcion Pérez, Pilar Navarro, Patricio Aller, L. Garcia-Bermejo, Lucrecia Campayo

Publikováno v: Biochemical Pharmacology. 48:72-82

The action of two structurally related DNA intercalating agents has been studied and compared, namely 4'-(9-acridinylamino) methanesulphon-m-anisidide (amsacrine, mAMSA) and 1,4-bis(butylamino)benzo[g]phthalazine (ABP) on the cell cycle and different

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c07fefa8136c94e2e082490133ff4279
https://doi.org/10.1016/0006-2952(94)90225-9

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Formation of mono- and di- nuclear complexes of Zn2+ from a 26 membered tetraester crown of 3,5-disubstituted pyrazole able to act as neutral and dianionic ligand

Autor: Lucrecia Campayo, Jose M. Bueno, Pilar Navarro, Carmen Acerete, M. Isabel Rodríguez-Franco, André Samat

Publikováno v: Tetrahedron. 50:4765-4774

A selective synthesis of bis(3,5-diketo-1H-pyrazole)-[26]crown- 12 ( 1 , L 1 ) has been performed. Its deprotonation pK a values, and those of the acyclic analogues ( 3 – 5 ) have been measured. The disodium dipyrazolate salt of 1 ( 2 , [L 2 ] 2- 2

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::18ebfe02749b511c20e67cf3712e47d4
https://doi.org/10.1016/s0040-4020(01)85015-8

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