Human regulatory T cells undergo self-inflicted damage via granzyme pathways upon activation.

Autor: Sula Karreci E; Transplantation Research Center, Renal Division, Brigham and Women's Hospital and Children's Hospital., Eskandari SK; Transplantation Research Center, Renal Division, Brigham and Women's Hospital and Children's Hospital., Dotiwala F; Program in Cellular and Molecular Medicine, Boston Children's Hospital., Routray SK; Transplantation Research Center, Renal Division, Brigham and Women's Hospital and Children's Hospital., Kurdi AT; Department of Medical Oncology, Dana-Farber Cancer Institute, and., Assaker JP; Transplantation Research Center, Renal Division, Brigham and Women's Hospital and Children's Hospital., Luckyanchykov P; Transplantation Research Center, Renal Division, Brigham and Women's Hospital and Children's Hospital., Mihali AB; Transplantation Research Center, Renal Division, Brigham and Women's Hospital and Children's Hospital., Maarouf O; Transplantation Research Center, Renal Division, Brigham and Women's Hospital and Children's Hospital., Borges TJ; Transplantation Research Center, Renal Division, Brigham and Women's Hospital and Children's Hospital., Alkhudhayri A; Transplantation Research Center, Renal Division, Brigham and Women's Hospital and Children's Hospital., Patel KR; Ann Romney Center for Neurologic Diseases, Brigham and Women's Hospital, Harvard Medical School, Massachusetts, USA., Radwan A; Transplantation Research Center, Renal Division, Brigham and Women's Hospital and Children's Hospital., Ghobrial I; Department of Medical Oncology, Dana-Farber Cancer Institute, and., McGrath M; Transplantation Research Center, Renal Division, Brigham and Women's Hospital and Children's Hospital., Chandraker A; Transplantation Research Center, Renal Division, Brigham and Women's Hospital and Children's Hospital., Riella LV; Transplantation Research Center, Renal Division, Brigham and Women's Hospital and Children's Hospital., Elyaman W; Ann Romney Center for Neurologic Diseases, Brigham and Women's Hospital, Harvard Medical School, Massachusetts, USA., Abdi R; Transplantation Research Center, Renal Division, Brigham and Women's Hospital and Children's Hospital., Lieberman J; Program in Cellular and Molecular Medicine, Boston Children's Hospital., Azzi J; Transplantation Research Center, Renal Division, Brigham and Women's Hospital and Children's Hospital.

Publikováno v: JCI insight [JCI Insight] 2017 Nov 02; Vol. 2 (21). Date of Electronic Publication: 2017 Nov 02.