Výsledky vyhledávání - "Luckhurst CA"

Akademický článek

Knockout or inhibition of USP30 protects dopaminergic neurons in a Parkinson's disease mouse model.

Autor: Fang TZ; Department of Neurology, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA, USA. szhang9@bidmc.harvard.edu., Sun Y; UK Dementia Research Institute at the University of Cambridge and Department of Clinical Neurosciences, University of Cambridge, Cambridge Biomedical Campus, Cambridge, CB2 0AH, UK., Pearce AC; Mission Therapeutics Ltd. Glenn Berge Building, Babraham Research Campus, Cambridge, CB22 3FH, UK., Eleuteri S; Department of Neurology, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA, USA., Kemp M; Mission Therapeutics Ltd. Glenn Berge Building, Babraham Research Campus, Cambridge, CB22 3FH, UK., Luckhurst CA; Mission Therapeutics Ltd. Glenn Berge Building, Babraham Research Campus, Cambridge, CB22 3FH, UK., Williams R; Mission Therapeutics Ltd. Glenn Berge Building, Babraham Research Campus, Cambridge, CB22 3FH, UK., Mills R; Mission Therapeutics Ltd. Glenn Berge Building, Babraham Research Campus, Cambridge, CB22 3FH, UK., Almond S; Mission Therapeutics Ltd. Glenn Berge Building, Babraham Research Campus, Cambridge, CB22 3FH, UK., Burzynski L; Mission Therapeutics Ltd. Glenn Berge Building, Babraham Research Campus, Cambridge, CB22 3FH, UK., Márkus NM; Mission Therapeutics Ltd. Glenn Berge Building, Babraham Research Campus, Cambridge, CB22 3FH, UK., Lelliott CJ; Wellcome Sanger Institute, Cambridge, CB10 1SA, UK., Karp NA; Wellcome Sanger Institute, Cambridge, CB10 1SA, UK., Adams DJ; Wellcome Sanger Institute, Cambridge, CB10 1SA, UK., Jackson SP; Mission Therapeutics Ltd. Glenn Berge Building, Babraham Research Campus, Cambridge, CB22 3FH, UK.; The Gurdon Institute and Department of Biochemistry, University of Cambridge, Cambridge, CB2 1QN, UK.; Cancer Research UK Cambridge Institute, University of Cambridge, Cambridge Biomedical Campus, Cambridge, CB2 0RE, UK., Zhao JF; MRC Protein Phosphorylation and Ubiquitylation Unit, University of Dundee, Dundee, DD1 5EH, UK., Ganley IG; MRC Protein Phosphorylation and Ubiquitylation Unit, University of Dundee, Dundee, DD1 5EH, UK., Thompson PW; Mission Therapeutics Ltd. Glenn Berge Building, Babraham Research Campus, Cambridge, CB22 3FH, UK. PThompson@missiontherapeutics.com., Balmus G; UK Dementia Research Institute at the University of Cambridge and Department of Clinical Neurosciences, University of Cambridge, Cambridge Biomedical Campus, Cambridge, CB2 0AH, UK. gb318@cam.ac.uk.; Department of Molecular Neuroscience, Transylvanian Institute of Neuroscience, 400191, Cluj-Napoca, Romania. gb318@cam.ac.uk., Simon DK; Department of Neurology, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA, USA.

Publikováno v: Nature communications [Nat Commun] 2023 Nov 13; Vol. 14 (1), pp. 7295. Date of Electronic Publication: 2023 Nov 13.

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Akademický článek

Identification of a Potent, Selective, and Brain-Penetrant Rho Kinase Inhibitor and its Activity in a Mouse Model of Huntington's Disease.

Autor: Ladduwahetty T; Discovery from Charles River, Chesterford Research Park, Saffron Walden CB10 1XL, U.K., Lee MR; CHDI Management/CHDI Foundation, 6080 Center Drive, Los Angeles, California 90045, United States., Maillard MC; CHDI Management/CHDI Foundation, 6080 Center Drive, Los Angeles, California 90045, United States., Cachope R; CHDI Management/CHDI Foundation, 6080 Center Drive, Los Angeles, California 90045, United States., Todd D; Discovery from Charles River, Chesterford Research Park, Saffron Walden CB10 1XL, U.K., Barnes M; Discovery from Charles River, Chesterford Research Park, Saffron Walden CB10 1XL, U.K., Beaumont V; CHDI Management/CHDI Foundation, 6080 Center Drive, Los Angeles, California 90045, United States., Chauhan A; Discovery from Charles River, Chesterford Research Park, Saffron Walden CB10 1XL, U.K., Gallati C; Discovery from Charles River, Chesterford Research Park, Saffron Walden CB10 1XL, U.K., Haughan AF; Discovery from Charles River, Chesterford Research Park, Saffron Walden CB10 1XL, U.K., Kempf G; Proteros Biostructures GmbH, Bunsenstr. 7a, D-82152 Planegg-Martinsried, Germany., Luckhurst CA; Discovery from Charles River, Chesterford Research Park, Saffron Walden CB10 1XL, U.K., Matthews K; Discovery from Charles River, Chesterford Research Park, Saffron Walden CB10 1XL, U.K., McAllister G; Discovery from Charles River, Chesterford Research Park, Saffron Walden CB10 1XL, U.K., Mitchell P; Discovery from Charles River, Chesterford Research Park, Saffron Walden CB10 1XL, U.K., Patel H; Discovery from Charles River, Chesterford Research Park, Saffron Walden CB10 1XL, U.K., Rose M; CHDI Management/CHDI Foundation, 6080 Center Drive, Los Angeles, California 90045, United States., Saville-Stones E; Discovery from Charles River, Chesterford Research Park, Saffron Walden CB10 1XL, U.K., Steinbacher S; Proteros Biostructures GmbH, Bunsenstr. 7a, D-82152 Planegg-Martinsried, Germany., Stott AJ; Discovery from Charles River, Chesterford Research Park, Saffron Walden CB10 1XL, U.K., Thatcher E; Discovery from Charles River, Chesterford Research Park, Saffron Walden CB10 1XL, U.K., Tierney J; Discovery from Charles River, Chesterford Research Park, Saffron Walden CB10 1XL, U.K., Urbonas L; Discovery from Charles River, Chesterford Research Park, Saffron Walden CB10 1XL, U.K., Munoz-Sanjuan I; CHDI Management/CHDI Foundation, 6080 Center Drive, Los Angeles, California 90045, United States., Dominguez C; CHDI Management/CHDI Foundation, 6080 Center Drive, Los Angeles, California 90045, United States.

Publikováno v: Journal of medicinal chemistry [J Med Chem] 2022 Jul 28; Vol. 65 (14), pp. 9819-9845. Date of Electronic Publication: 2022 Jul 11.

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Akademický článek

Evaluation of 5-(Trifluoromethyl)-1,2,4-oxadiazole-Based Class IIa HDAC Inhibitors for Huntington's Disease.

Autor: Stott AJ; Charles River Discovery, Chesterford Research Park, Saffron Walden, Essex CB10 1XL, United Kingdom., Maillard MC; CHDI Management/CHDI Foundation Inc., 6080 Center Drive, Suite 700, Los Angeles, California 90045, United States., Beaumont V; CHDI Management/CHDI Foundation Inc., 6080 Center Drive, Suite 700, Los Angeles, California 90045, United States., Allcock D; Charles River Discovery, Chesterford Research Park, Saffron Walden, Essex CB10 1XL, United Kingdom., Aziz O; Charles River Discovery, Chesterford Research Park, Saffron Walden, Essex CB10 1XL, United Kingdom., Borchers AH; CHDI Management/CHDI Foundation Inc., 6080 Center Drive, Suite 700, Los Angeles, California 90045, United States., Blackaby W; Charles River Discovery, Chesterford Research Park, Saffron Walden, Essex CB10 1XL, United Kingdom., Breccia P; Charles River Discovery, Chesterford Research Park, Saffron Walden, Essex CB10 1XL, United Kingdom., Creighton-Gutteridge G; Charles River Discovery, Chesterford Research Park, Saffron Walden, Essex CB10 1XL, United Kingdom., Haughan AF; Charles River Discovery, Chesterford Research Park, Saffron Walden, Essex CB10 1XL, United Kingdom., Jarvis RE; Charles River Discovery, Chesterford Research Park, Saffron Walden, Essex CB10 1XL, United Kingdom., Luckhurst CA; Charles River Discovery, Chesterford Research Park, Saffron Walden, Essex CB10 1XL, United Kingdom., Matthews KL; Charles River Discovery, Chesterford Research Park, Saffron Walden, Essex CB10 1XL, United Kingdom., McAllister G; Charles River Discovery, Chesterford Research Park, Saffron Walden, Essex CB10 1XL, United Kingdom., Pollack S; Charles River Discovery, Chesterford Research Park, Saffron Walden, Essex CB10 1XL, United Kingdom., Saville-Stones E; Charles River Discovery, Chesterford Research Park, Saffron Walden, Essex CB10 1XL, United Kingdom., Van de Poël AJ; Charles River Discovery, Chesterford Research Park, Saffron Walden, Essex CB10 1XL, United Kingdom., Vater HD; Charles River Discovery, Chesterford Research Park, Saffron Walden, Essex CB10 1XL, United Kingdom., Vann J; Charles River Discovery, Chesterford Research Park, Saffron Walden, Essex CB10 1XL, United Kingdom., Williams R; Charles River Discovery, Chesterford Research Park, Saffron Walden, Essex CB10 1XL, United Kingdom., Yates D; Charles River Discovery, Chesterford Research Park, Saffron Walden, Essex CB10 1XL, United Kingdom., Muñoz-Sanjuán I; CHDI Management/CHDI Foundation Inc., 6080 Center Drive, Suite 700, Los Angeles, California 90045, United States., Dominguez C; CHDI Management/CHDI Foundation Inc., 6080 Center Drive, Suite 700, Los Angeles, California 90045, United States.

Publikováno v: ACS medicinal chemistry letters [ACS Med Chem Lett] 2021 Feb 11; Vol. 12 (3), pp. 380-388. Date of Electronic Publication: 2021 Feb 11 (Print Publication: 2021).

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