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Akademický článek

P2X4 Receptor Function in the Nervous System and Current Breakthroughs in Pharmacology

Autor: Leanne Stokes, Janice A. Layhadi, Lucka Bibic, Kshitija Dhuna, Samuel J. Fountain

Publikováno v: Frontiers in Pharmacology, Vol 8 (2017)

Adenosine 5′-triphosphate is a well-known extracellular signaling molecule and neurotransmitter known to activate purinergic P2X receptors. Information has been elucidated about the structure and gating of P2X channels following the determination o

Externí odkaz: https://doaj.org/article/f86b15d565184928947460be9f6f3e84

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Development of High-Throughput Fluorescent-Based Screens to Accelerate Discovery of P2X Inhibitors from Animal Venoms

Autor: Leanne Stokes, Glenn F. King, Lucka Bibic, Volker Herzig

Publikováno v: Journal of Natural Products

Animal venoms can play an important role in drug discovery, as they are a rich source of evolutionarily tuned compounds that target a variety of ion channels and receptors. To date, there are six FDA-approved drugs derived from animal venoms, with re

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e737c51f6670646415805f5325950f36
http://europepmc.org/articles/PMC7123434

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Revisiting the Idea That Amyloid-β Peptide Acts as an Agonist for P2X7

Autor: Leanne Stokes, Lucka Bibic

Publikováno v: Frontiers in Molecular Neuroscience, Vol 13 (2020)
Frontiers in Molecular Neuroscience

The P2X7 receptor (P2X7) is a cell surface ligand-gated ion channel, activated by its physiological nucleotide agonist ATP and a synthetic analog (BzATP). However, it has also been suggested that there may be structurally unrelated, non-nucleotide ag

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5a2c529e425914aa6f3bcdda5bf27f7d
https://www.frontiersin.org/article/10.3389/fnmol.2020.00166/full

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To Inhibit or Enhance? Is There a Benefit to Positive Allosteric Modulation of P2X Receptors?

Autor: Leanne Stokes, Lucka Bibic, Elizabeth Allum, Stefan Bidula

Publikováno v: Frontiers in Pharmacology, Vol 11 (2020)
Frontiers in Pharmacology

The family of ligand-gated ion channels known as P2X receptors were discovered several decades ago. Since the cloning of the seven P2X receptors (P2X1-P2X7), a huge research effort has elucidated their roles in regulating a range of physiological and

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4f470dc1df20aa7197068afc4fbe90ed
https://doi.org/10.3389/fphar.2020.00627

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A diverse view of science to catalyse change

Publikováno v: ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
CROATICA CHEMICA ACTA
Croatica Chemica Acta
Volume 93
Issue 1
Angewandte Chemie (International ed. in English), vol 59, iss 42
Angewandte Chemie (International Ed. in English)

Valuing diversity leads to scientific excellence, the progress of science and most importantly, it is simply the right thing to do. We can value diversity not only in words, but also in actions. From the structure of DNA,1 to computer science,2 and s

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9727161b2d2d9bcce5d63ae26be8878e

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Design and development of stapled transmembrane peptides that disrupt the activity of G-protein coupled receptor oligomers

Autor: Lesley A. Howell, Peter J. McCormick, Joaquin Botta, Patrick M. Killoran, Lucka Bibic

Publikováno v: The Journal of Biological Chemistry

Membrane proteins can associate into larger complexes. Examples include receptor tyrosine complexes, ion channels, transporters, and G protein–coupled receptors (GPCRs). For the latter, there is abundant evidence indicating that GPCRs assemble into

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ef9244a0610b8bee48d49346556b0e83
https://ueaeprints.uea.ac.uk/id/eprint/72180/

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Bug off pain: An educational virtual reality game on spider venoms and chronic pain for public engagement

Autor: Lucka Bibic, Samuel Walpole, Jesús Angulo, Leanne Stokes, Justinas Druskis

Virtual reality (VR) technology has been capturing the public imagination for decades. VR software applications that allow for interactive immersion are emerging as a renowned medium in many areas, including educating the public in biochemistry-relat

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f51cfc846ff8855729345d85399fbc10
https://ueaeprints.uea.ac.uk/id/eprint/71119/

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