Zobrazeno 1 - 10
of 134
pro vyhledávání: '"Lucio, Gama"'
Autor:
Joana Dias, Giulia Fabozzi, Slim Fourati, Xuejun Chen, Cuiping Liu, David R. Ambrozak, Amy Ransier, Farida Laboune, Jianfei Hu, Wei Shi, Kylie March, Anna A. Maximova, Stephen D. Schmidt, Jakob Samsel, Chloe A. Talana, Keenan Ernste, Sung Hee Ko, Margaret E. Lucas, Pierce E. Radecki, Kristin L. Boswell, Yoshiaki Nishimura, John-Paul Todd, Malcolm A. Martin, Constantinos Petrovas, Eli A. Boritz, Nicole A. Doria-Rose, Daniel C. Douek, Rafick-Pierre Sékaly, Jeffrey D. Lifson, Mangaiarkarasi Asokan, Lucio Gama, John R. Mascola, Amarendra Pegu, Richard A. Koup
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-18 (2024)
Abstract Anti-HIV-1 broadly neutralizing antibodies (bNAbs) have the dual potential of mediating virus neutralization and antiviral effector functions through their Fab and Fc domains, respectively. So far, bNAbs with enhanced Fc effector functions i
Externí odkaz:
https://doaj.org/article/bf19edfc45874c86ab18e09d0df26155
Autor:
Ameena Goga, Trisha Ramraj, Logashvari Naidoo, Brodie Daniels, Masefetsane Matlou, Terusha Chetty, Reshmi Dassaye, Nobubelo K. Ngandu, Laura Galli, Tarylee Reddy, Ishen Seocharan, Qondeni Ndlangamandla, Qholokazi September, Nokwanda Ngcobo, Mayuri Reddy, Tamon Cafun-Naidoo, Kubashni Woeber, Nitesha Jeenarain, Rabia Imamdin, Keshnee Maharajh, Ashmintha Ramjeth, Thobile Bhengu, Emma Clarence, Philippe Van de Perre, Thorkild Tylleskär, Nicolas Nagot, Jean-Pierre Moles, Penny L. Moore, Nonhlanhla N. Mkhize, Lucio Gama, Stefania Dispinseri, Priscilla Biswas, Gabriella Scarlatti, the PedMAb1 clinical trial team
Publikováno v:
BMC Infectious Diseases, Vol 24, Iss 1, Pp 1-17 (2024)
Abstract Background The ambitious goal to eliminate new pediatric HIV infections by 2030 requires accelerated prevention strategies in high-risk settings such as South Africa. One approach could be pre-exposure prophylaxis (PrEP) with broadly neutral
Externí odkaz:
https://doaj.org/article/289c4aae8d584a3bb56f8bc46eb6cc68
Autor:
Stephen R Walsh, Cynthia L Gay, Shelly T Karuna, Ollivier Hyrien, Timothy Skalland, Kenneth H Mayer, Magdalena E Sobieszczyk, Lindsey R Baden, Paul A Goepfert, Carlos Del Rio, Guiseppe Pantaleo, Philip Andrew, Carissa Karg, Zonglin He, Huiyin Lu, Carmen A Paez, Jane A G Baumblatt, Laura L Polakowski, Wairimu Chege, Maija A Anderson, Sophie Janto, Xue Han, Yunda Huang, Julie Dumond, Margaret E Ackerman, Adrian B McDermott, Britta Flach, Estelle Piwowar-Manning, Kelly Seaton, Georgia D Tomaras, David C Montefiori, Lucio Gama, John R Mascola, HVTN 127/HPTN 087 Study Team
Publikováno v:
PLoS Medicine, Vol 21, Iss 6, p e1004329 (2024)
BackgroundBroadly neutralizing antibodies (bnAbs) are a promising approach for HIV-1 prevention. In the Antibody Mediated Prevention (AMP) trials, a CD4-binding site targeting bnAb, VRC01, administered intravenously (IV), demonstrated 75% prevention
Externí odkaz:
https://doaj.org/article/4be70ce338214ab0a34f240e9ededde1
Autor:
Yunda Huang, Lily Zhang, Shelly Karuna, Philip Andrew, Michal Juraska, Joshua A. Weiner, Heather Angier, Evgenii Morgan, Yasmin Azzam, Edith Swann, Srilatha Edupuganti, Nyaradzo M. Mgodi, Margaret E. Ackerman, Deborah Donnell, Lucio Gama, Peter L. Anderson, Richard A. Koup, John Hural, Myron S. Cohen, Lawrence Corey, M. Juliana McElrath, Peter B. Gilbert, Maria P. Lemos
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-19 (2023)
Abstract Broadly neutralizing monoclonal antibodies (mAbs) are being developed for HIV-1 prevention. Hence, these mAbs and licensed oral pre-exposure prophylaxis (PrEP) (tenofovir-emtricitabine) can be concomitantly administered in clinical trials. I
Externí odkaz:
https://doaj.org/article/1573cc55a90c4367a36a05f7470f768e
Autor:
Bryan T. Mayer, Lily Zhang, Allan C. deCamp, Chenchen Yu, Alicia Sato, Heather Angier, Kelly E. Seaton, Nicole Yates, Julie E. Ledgerwood, Kenneth Mayer, Marina Caskey, Michel Nussenzweig, Kathryn Stephenson, Boris Julg, Dan H. Barouch, Magdalena E. Sobieszczyk, Srilatha Edupuganti, Colleen F. Kelley, M. Juliana McElrath, Huub C. Gelderblom, Michael Pensiero, Adrian McDermott, Lucio Gama, Richard A. Koup, Peter B. Gilbert, Myron S. Cohen, Lawrence Corey, Ollivier Hyrien, Georgia D. Tomaras, Yunda Huang
Publikováno v:
Pharmaceutics, Vol 16, Iss 5, p 594 (2024)
Monoclonal antibodies are commonly engineered with an introduction of Met428Leu and Asn434Ser, known as the LS mutation, in the fragment crystallizable region to improve pharmacokinetic profiles. The LS mutation delays antibody clearance by enhancing
Externí odkaz:
https://doaj.org/article/34ca5d472d9b40e7a742cd8a83e9c15b
Autor:
Baoshan Zhang, Deepika Gollapudi, Jason Gorman, Sijy O’Dell, Leland F. Damron, Krisha McKee, Mangaiarkarasi Asokan, Eun Sung Yang, Amarendra Pegu, Bob C. Lin, Cara W. Chao, Xuejun Chen, Lucio Gama, Vera B. Ivleva, William H. Law, Cuiping Liu, Mark K. Louder, Stephen D. Schmidt, Chen-Hsiang Shen, Wei Shi, Judith A. Stein, Michael S. Seaman, Adrian B. McDermott, Kevin Carlton, John R. Mascola, Peter D. Kwong, Q. Paula Lei, Nicole A. Doria-Rose
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-11 (2022)
Abstract The broadly neutralizing antibody (bNAb) CAP256-VRC26.25 has exceptional potency against HIV-1 and has been considered for clinical use. During the characterization and production of this bNAb, we observed several unusual features. First, th
Externí odkaz:
https://doaj.org/article/feda1737f1ab462b8d29f0c9ddbd2f07
Autor:
Nigel Garrett, Farzana Osman, Sharana Mahomed, Edmund Capparelli, Nonhlanhla Yende Zuma, Derseree Archary, Penny Moore, Natasha Samsunder, Lynn Morris, Salim Abdool Karim, Catherine Hankins, Carolyn Williamson, Bruno Pozzetto, Kevin Carlton, Richard A Koup, Quarraisha Abdool Karim, Leila Mansoor, Tanuja Narayansamy Gengiah, Ishana Harkoo, Precious Radebe, Izukanji T Sikazwe, Disebo Potloane, Nqobile Myeni, Lucio Gama, Sandeep Narpala, Leonid Serebryannyy, Nicole Doria-Rose
Publikováno v:
BMJ Open, Vol 13, Iss 8 (2023)
Introduction Women-controlled HIV prevention technologies that overcome adherence challenges of available daily oral pre-exposure prophylaxis and give women a choice of options are urgently needed. Broadly neutralising monoclonal antibodies (bnAbs) a
Externí odkaz:
https://doaj.org/article/88fe366c8a104a4da061d0ee7548e10d
Autor:
Denis R. Beckford-Vera, Robert R. Flavell, Youngho Seo, Enrique Martinez-Ortiz, Maya Aslam, Cassandra Thanh, Emily Fehrman, Marion Pardons, Shreya Kumar, Amelia N. Deitchman, Vahid Ravanfar, Brailee Schulte, I-Wei Katherine Wu, Tony Pan, Jacqueline D. Reeves, Christopher C. Nixon, Nikita S. Iyer, Leonel Torres, Sadie E. Munter, Tony Hyunh, Christos J. Petropoulos, Rebecca Hoh, Benjamin L. Franc, Lucio Gama, Richard A. Koup, John R. Mascola, Nicolas Chomont, Steven G. Deeks, Henry F. VanBrocklin, Timothy J. Henrich
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-15 (2022)
Here, the authors apply positron emission tomography (PET) imaging to visualize HIV tissue-wide burden in infected individuals using a radiolabeled broadly neutralizing antibody, 89Zr-VRC01, and show that PET tracer lymph node uptake positively corre
Externí odkaz:
https://doaj.org/article/42a11e0860df4b12b471a443fa8f7ecb
Autor:
Kristin L. Boswell, Timothy A. Watkins, Evan M. Cale, Jakob Samsel, Sarah F. Andrews, David R. Ambrozak, Jefferson I. Driscoll, Michael A. Messina, Sandeep Narpala, Christine S. Hopp, Alberto Cagigi, Joseph P. Casazza, Takuya Yamamoto, Tongqing Zhou, William R. Schief, Peter D. Crompton, Julie E. Ledgerwood, Mark Connors, Lucio Gama, Peter D. Kwong, Adrian McDermott, John R. Mascola, Richard A. Koup
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
The isolation and characterization of neutralizing antibodies from infection and vaccine settings informs future vaccine design, and methodologies that streamline the isolation of antibodies and the generation of B cell clones are of great interest.
Externí odkaz:
https://doaj.org/article/5545d1b2bd774ffa82a9c22a398ffe25
Autor:
Mikhaïl A. Van Herck, Luisa Vonghia, Wilhelmus J. Kwanten, Yvon Julé, Thomas Vanwolleghem, Didier G. Ebo, Peter P. Michielsen, Joris G. De Man, Lucio Gama, Benedicte Y. De Winter, Sven M. Francque
Publikováno v:
Cellular and Molecular Gastroenterology and Hepatology, Vol 10, Iss 3, Pp 467-490 (2020)
Background & Aims: Nonalcoholic steatohepatitis (NASH) is a multisystem condition, implicating liver and adipose tissue. Although the general involvement of the innate and adaptive immune system has been established, we aimed to define the exact role
Externí odkaz:
https://doaj.org/article/4e44727ed95a41d9b6a985c3cf095b2d