Zobrazeno 1 - 10
of 116
pro vyhledávání: '"Lucinactant"'
Publikováno v:
Journal of Aerosol Medicine and Pulmonary Drug Delivery
Background: Lucinactant for inhalation is an investigational noninvasive, aerosolized surfactant replacement therapy for treatment of preterm neonates with respiratory distress syndrome. Lucinactant for inhalation consists of lyophilized lucinactant
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::62718ec5d57b5bfacacee566e43e4d66
https://doi.org/10.1089/jamp.2018.1505
https://doi.org/10.1089/jamp.2018.1505
Autor:
Ga Won Jeon
Publikováno v:
Korean Journal of Pediatrics
Korean Journal of Pediatrics, Vol 62, Iss 5, Pp 155-161 (2019)
Korean Journal of Pediatrics, Vol 62, Iss 5, Pp 155-161 (2019)
Following the first successful trial of surfactant replacement therapy for preterm infants with respiratory distress syndrome (RDS) by Fujiwara in 1980, several animal-derived natural surfactants and synthetic surfactants have been developed. Synthet
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6c4c823b8fe8842138bd63bf067f1cb8
https://doi.org/10.3345/kjp.2018.07185
https://doi.org/10.3345/kjp.2018.07185
Autor:
Steven M. Donn, Brian K. Jordan
Publikováno v:
Expert Review of Clinical Pharmacology. 6:115-121
Respiratory distress syndrome (RDS) is the leading cause of neonatal morbidity and mortality in premature infants. It is caused by surfactant deficiency and lung immaturity. Lucinactant is a synthetic surfactant containing sinapultide, a bioengineere
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cdc193b733d93cc3d4ddddfdfc8ff752
https://doi.org/10.1586/ecp.12.80
https://doi.org/10.1586/ecp.12.80
Autor:
Secil Ercin, Fahri Ovali
Publikováno v:
Volume: 8, Issue: 0
Journal of Pediatric Sciences
Journal of Pediatric Sciences
Animal derived natural surfactants have been used in the treatment of neonatal respiratory distress syndrome for nearly 25 years with great success, but new, better and cheap surfactants are still needed. THese new surfactants are mostly synthetic an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::25eac7e4ca81355cf8609e1b6f4be432
https://dergipark.org.tr/tr/pub/jps/issue/19092/615053
https://dergipark.org.tr/tr/pub/jps/issue/19092/615053
Autor:
Sunil K. Sinha, Robert Segal, Fernando Moya, Phillip D. Simmons, Carlos Guardia, Jay S. Greenspan
Publikováno v:
The Journal of Pediatric Pharmacology and Therapeutics. 17:220-227
OBJECTIVESReintubation and subsequent mechanical ventilation (MV) in preterm infants after surfactant replacement therapy are associated with excess morbidity and mortality and likely increase in-hospital costs. Specific surfactant therapy selection
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::192d0611c22c3c49f9ee6780f550ebb4
https://doi.org/10.5863/1551-6776-17.3.220
https://doi.org/10.5863/1551-6776-17.3.220
Autor:
Neal J, Thomas, Carlos G, Guardia, Fernando R, Moya, Ira M, Cheifetz, Barry, Markovitz, Pablo, Cruces, Phillip, Barton, Robert, Segal, Phillip, Simmons, Adrienne G, Randolph, Michele L, Shaffer
Publikováno v:
Pediatric Critical Care Medicine. 13:646-653
Background: Inhibition of surfactant function and abnormal surfactant synthesis lead to surfactant dysfunction in children with acute hypoxemic respiratory failure.] Objective: We evaluated whether intratracheal lucinactant, a synthetic, peptide-cont
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::21b62327666dc780aa921e9e46a1b58f
https://doi.org/10.1097/pcc.0b013e3182517bec
https://doi.org/10.1097/pcc.0b013e3182517bec
Autor:
Sze Ma, Christopher Cheng-Hwa Ma
Publikováno v:
The Open Respiratory Medicine Journal
The key feature of respiratory distress syndrome (RDS) is the insufficient production of surfactant in the lungs of preterm infants. As a result, researchers have looked into the possibility of surfactant replacement therapy as a means of preventing
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::27e7d33e85db50befe2c1fa7efdbc35f
http://europepmc.org/articles/PMC3409350
http://europepmc.org/articles/PMC3409350
Autor:
Hector Lafuente, Xabier Murgia, Adolfo Valls-i-Soler, Francisco J. Alvarez-Diaz, Carmen Rey-Santano, Victoria E. Mielgo, Elena Gastiasoro
Publikováno v:
Pediatric Critical Care Medicine. 13:e187-e194
OBJECTIVE Today, in meconium aspiration syndrome, treatment focuses on bronchoalveolar lavage, because it removes meconium and proinflammatory factors from airways. This technique might be more effective if different solutions were used such as salin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2141680748b169c7d52792ff228aaf58
https://doi.org/10.1097/pcc.0b013e318238b17f
https://doi.org/10.1097/pcc.0b013e318238b17f
Publikováno v:
Pediatric Research. 72:32-37
A lyophilized formulation of lucinactant has been developed to simplify preparation and dosing. Endotracheal administration of surfactant can be associated with potentially harmful transient hemodynamic changes including decreases in cerebral blood f
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5c62e8fb8a8495e43eea3b165b45ff1c
https://doi.org/10.1038/pr.2012.46
https://doi.org/10.1038/pr.2012.46
Autor:
Xabier Murgia, Francisco J. Alvarez-Diaz, E Ruiz-del-Yerro, Elena Gastiasoro, Hector Lafuente, Carmen Rey-Santano, Victoria E. Mielgo, A Valls-i-Soler
Publikováno v:
Pediatric Pulmonology. 46:991-999
This study was designed to study effects of lung lavage versus the classical bolus instillation with a peptide-based synthetic surfactant (lucinactant) in a model of Meconium Aspiration Syndrome (MAS). Eighteen newborn lambs received meconium and wer
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::af55cf323bb2ff33d9354e987fe2a56a
https://doi.org/10.1002/ppul.21460
https://doi.org/10.1002/ppul.21460