Výsledky vyhledávání - "Lucille M Rich"

Akademický článek

Temperature synchronisation of circadian rhythms in primary human airway epithelial cells from children

Autor: Weston T Powell, Lucille M Rich, Elizabeth R Vanderwall, Maria P White, Jason S Debley

Publikováno v: BMJ Open Respiratory Research, Vol 9, Iss 1 (2022)

Introduction Cellular circadian rhythms regulate immune pathways and inflammatory responses that mediate human disease such as asthma. Circadian rhythms in the lung may also contribute to exacerbations of chronic diseases such as asthma by regulating

Externí odkaz: https://doaj.org/article/c53fff4510a8422d905772e53cf4f7e4

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Akademický článek

Highly synergistic combinations of nanobodies that target SARS-CoV-2 and are resistant to escape

Publikováno v: eLife, Vol 10 (2021)

The emergence of SARS-CoV-2 variants threatens current vaccines and therapeutic antibodies and urgently demands powerful new therapeutics that can resist viral escape. We therefore generated a large nanobody repertoire to saturate the distinct and hi

Externí odkaz: https://doaj.org/article/81f21ae91fa645928a68302720f1052b

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Akademický článek

Stability of gene expression by primary bronchial epithelial cells over increasing passage number

Autor: Stephen R. Reeves, Kaitlyn A. Barrow, Maria P. White, Lucille M. Rich, Maryam Naushab, Jason S. Debley

Publikováno v: BMC Pulmonary Medicine, Vol 18, Iss 1, Pp 1-11 (2018)

Abstract Background An increasing number of studies using primary human bronchial epithelial cells (BECs) have reported intrinsic differences in the expression of several genes between cells from asthmatic and non-asthmatic donors. The stability of g

Externí odkaz: https://doaj.org/article/46dfa1045843498eab89a507fc6ba815

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Akademický článek

Respiratory Syncytial Virus Infection of Human Lung Fibroblasts Induces a Hyaluronan-Enriched Extracellular Matrix That Binds Mast Cells and Enhances Expression of Mast Cell Proteases

Autor: Stephen R. Reeves, Kaitlyn A. Barrow, Lucille M. Rich, Maria P. White, Nicholas J. Shubin, Christina K. Chan, Inkyung Kang, Steven F. Ziegler, Adrian M. Piliponsky, Thomas N. Wight, Jason S. Debley

Publikováno v: Frontiers in Immunology, Vol 10 (2020)

Human lung fibroblasts (HLFs) treated with the viral mimetic polyinosine-polycytidylic acid (poly I:C) form an extracellular matrix (ECM) enriched in hyaluronan (HA) that avidly binds monocytes and lymphocytes. Mast cells are important innate immune

Externí odkaz: https://doaj.org/article/7c17dc8327b34d829110902b4e1ab511

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Tuft cell-derived acetylcholine regulates epithelial fluid secretion

Autor: Tyler E. Billipp, Connie Fung, Lily M. Webeck, Derek B. Sargent, Matthew B. Gologorsky, Margaret M. McDaniel, Darshan N. Kasal, John W. McGinty, Kaitlyn A. Barrow, Lucille M. Rich, Alessio Barilli, Mark Sabat, Jason S. Debley, Richard Myers, Michael R. Howitt, Jakob von Moltke

Publikováno v: bioRxiv

Tuft cells are solitary chemosensory epithelial cells that can sense lumenal stimuli at mucosal barriers and secrete effector molecules to regulate the physiology and immune state of their surrounding tissue. In the small intestine, tuft cells detect

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e7a5077dec2253525a95e08a19d5a318
https://doi.org/10.1101/2023.03.17.533208

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IgM antibodies derived from memory B cells are potent cross-variant neutralizers of SARS-CoV-2

Publikováno v: The Journal of experimental medicine. 219(9)

Humoral immunity to SARS-CoV-2 can be supplemented with polyclonal sera from convalescent donors or an engineered monoclonal antibody (mAb) product. While pentameric IgM antibodies are responsible for much of convalescent sera’s neutralizing capaci

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1a2ad5a20085cb3b87ebd4b689c5e4a4
https://pubmed.ncbi.nlm.nih.gov/36036783

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Highly synergistic combinations of nanobodies that target SARS-CoV-2 and are resistant to escape

Publikováno v: bioRxiv
article-version (status) pre
article-version (number) 1
eLife, Vol 10 (2021)

SUMMARY Despite the great promise of vaccines, the COVID-19 pandemic is ongoing and future serious outbreaks are highly likely, so that multi-pronged containment strategies will be required for many years. Nanobodies are the smallest naturally occurr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::256e222ad1c80762e3e30acaf14d6531
https://doi.org/10.7554/elife.73027

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