Zobrazeno 1 - 7
of 7
pro vyhledávání: '"Lucille Lumley"'
Publikováno v:
Epilepsia Open, Vol 8, Iss S1, Pp S117-S140 (2023)
Abstract Despite new antiseizure medications, the development of cholinergic‐induced refractory status epilepticus (RSE) continues to be a therapeutic challenge as pharmacoresistance to benzodiazepines and other antiseizure medications quickly deve
Externí odkaz:
https://doaj.org/article/1aa984e56cb347e196acca6ed7c66a1d
Autor:
Lucille Lumley, Fu Du, Brenda Marrero-Rosado, Michael Stone, Zora-Maya Keith, Caroline Schultz, Kimberly Whitten, Katie Walker, Cindy Acon-Chen, Linnzi Wright, Tsung-Ming Shih
Publikováno v:
Toxicology Reports, Vol 8, Iss , Pp 896-907 (2021)
Animal models are essential for evaluating the toxicity of chemical warfare nerve agents (CWNAs) to extrapolate to human risk and are necessary to evaluate the efficacy of medical countermeasures. The Göttingen minipig is increasingly used for toxic
Externí odkaz:
https://doaj.org/article/15f8b06964f947a390606a8fa34d62cd
Autor:
Lucille Lumley, Dennis Miller, William T. Muse, Brenda Marrero‐Rosado, Marcio de Araujo Furtado, Michael Stone, Jeffrey McGuire, Christopher Whalley
Publikováno v:
Epilepsia Open, Vol 4, Iss 3, Pp 382-396 (2019)
Abstract Objective Our objective was to evaluate the protective efficacy of the neurosteroid pregnanolone (3α‐hydroxy‐5β pregnan‐20‐one), a GABAA receptor‐positive allosteric modulator, as an adjunct to benzodiazepine therapy against the
Externí odkaz:
https://doaj.org/article/42d2473c8f4c4c4f928e47706e64ac82
Autor:
Jerome Niquet, Lucille Lumley, Roger Baldwin, Franco Rossetti, Lucie Suchomelova, David Naylor, Ireri Betsabe Franco Estrada, Mark Schultz, Marcio de Araujo Furtado, Claude G. Wasterlain
Publikováno v:
Neurobiology of Disease, Vol 133, Iss , Pp - (2020)
The initiation and maintenance phases of cholinergic status epilepticus (SE) are associated with maladaptive trafficking of synaptic GABAA and glutamate receptors. The resulting pharmacoresistance reflects a decrease in synaptic GABAA receptors and i
Externí odkaz:
https://doaj.org/article/e78b0cb0c11a4a889c6e00efd4a6bfc2
Autor:
Jerome Niquet, Roger Baldwin, Keith Norman, Lucie Suchomelova, Lucille Lumley, Claude G. Wasterlain
Publikováno v:
Neurobiology of Disease, Vol 104, Iss , Pp 41-49 (2017)
Early maladaptive internalization of synaptic GABAA receptors (GABAAR) and externalization of NMDA receptors (NMDAR) may explain the time-dependent loss of potency of standard anti-epileptic drugs (AED) in refractory status epilepticus (SE). We hypot
Externí odkaz:
https://doaj.org/article/df4afc0d943b4ede9da1aa2e35651717
Autor:
Jerome, Niquet, Roger, Baldwin, Lucie, Suchomelova, Lucille, Lumley, David, Naylor, Roland, Eavey, Claude G, Wasterlain
Publikováno v:
Annals of the New York Academy of Sciences. 1378(1)
Cholinergic status epilepticus (CSE) quickly becomes self-sustaining, independent of its initial trigger, and resistant to benzodiazepines and other antiepileptic drugs. We review a few of the many physiological changes associated with CSE, with an e
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::8f33352acf272cdea6ac3406115a91bc
https://pubmed.ncbi.nlm.nih.gov/27392038
https://pubmed.ncbi.nlm.nih.gov/27392038
