Zobrazeno 1 - 7
of 7
pro vyhledávání: '"Lucille Kohlenberg"'
Autor:
Jared Carlson-Stevermer, Amritava Das, Amr A. Abdeen, David Fiflis, Benjamin I Grindel, Shivani Saxena, Tugce Akcan, Tausif Alam, Heidi Kletzien, Lucille Kohlenberg, Madelyn Goedland, Micah J. Dombroe, Krishanu Saha
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-18 (2020)
Gene correction of multiple alleles is a promising therapeutic strategy. Here the authors present bi-allelic correction of Pompe disease and provide an in silico model for predicting in vivo somatic editing outcomes.
Externí odkaz:
https://doaj.org/article/9ea7446371264a6ca5170a5851e05415
Autor:
Jared Carlson-Stevermer, Amr A. Abdeen, Lucille Kohlenberg, Madelyn Goedland, Kaivalya Molugu, Meng Lou, Krishanu Saha
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-13 (2017)
Using CRISPR to write specific genetic sequences can sometimes be difficult due to the preference of mammalian cells to repair breaks using NHEJ. Here the authors form nanoparticles to localize the template sequence to the nuclease, shifting repair i
Externí odkaz:
https://doaj.org/article/f08b65b2ded04098a2d3fda73679eeab
Autor:
Jared Carlson-Stevermer, Madelyn Goedland, Benjamin Steyer, Arezoo Movaghar, Meng Lou, Lucille Kohlenberg, Ryan Prestil, Krishanu Saha
Publikováno v:
Stem Cell Reports, Vol 6, Iss 1, Pp 109-120 (2016)
CRISPR-Cas9 gene editing of human cells and tissues holds much promise to advance medicine and biology, but standard editing methods require weeks to months of reagent preparation and selection where much or all of the initial edited samples are dest
Externí odkaz:
https://doaj.org/article/461c0091c8994da3a1b47b5bd26b8ac1
Autor:
Jared Carlson-Stevemer, Amritava Das, Amr Abdeen, David Fiflis, Benjamin Grindel, Tugce Akcan, Tausif Alam, Heidi Kletzien, Lucille Kohlenberg, Madelyn Goedland, Micah Dombroe, Krishanu Saha
Gene correction of multiple alleles for compound heterozygous recessive or polygenic diseases is a promising therapeutic strategy. However, the targeting of multiple alleles using genome editors in a single cell could lead to mixed genotypes and adve
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1c1c7a455fae82c05072d86031104ce1
https://doi.org/10.21203/rs.3.rs-90150/v1
https://doi.org/10.21203/rs.3.rs-90150/v1
Publikováno v:
Proceedings of the National Academy of Sciences. 114:13804-13809
Negative and positive feedback effects of ovarian 17β-estradiol (E2) regulating release of gonadotropin releasing hormone (GnRH) and luteinizing hormone (LH) are pivotal events in female reproductive function. While ovarian feedback on hypothalamo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ec0fd16b41e69537d3df111746734cd5
https://doi.org/10.1073/pnas.1716097115
https://doi.org/10.1073/pnas.1716097115
Autor:
Meng Lou, Benjamin Steyer, Lucille Kohlenberg, Madelyn Goedland, Arezoo Movaghar, Jared Carlson-Stevermer, Krishanu Saha, Ryan Prestil
Publikováno v:
Stem Cell Reports, Vol 6, Iss 1, Pp 109-120 (2016)
Stem Cell Reports
Stem Cell Reports
Summary CRISPR-Cas9 gene editing of human cells and tissues holds much promise to advance medicine and biology, but standard editing methods require weeks to months of reagent preparation and selection where much or all of the initial edited samples
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a37be80049cda5806a02d83b1051b761
http://www.sciencedirect.com/science/article/pii/S2213671115003653
http://www.sciencedirect.com/science/article/pii/S2213671115003653
Autor:
Arezoo Movaghar, Meng Lou, Krishanu Saha, Ryan Prestil, Madelyn Goedland, Benjamin Steyer, Lucille Kohlenberg, Jared Carlson-Stevermer
Publikováno v:
Molecular Therapy. 24:S229-S230
Gene-edited human cells are important resources for drug target identification, regulatory science, regenerative medicine and basic biology. Recently, use of the CRISPR-Cas9 system drastically cut the time required to produce gene-edited cell lines d
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::93fc67d99037fb788d988c5aa46f34f0
https://doi.org/10.1016/s1525-0016(16)33383-4
https://doi.org/10.1016/s1525-0016(16)33383-4