Zobrazeno 1 - 10
of 65
pro vyhledávání: '"Lucille A, Lumley"'
Autor:
Vassiliki Aroniadou-Anderjaska, Taiza H. Figueiredo, Marcio De Araujo Furtado, Volodymyr I. Pidoplichko, Lucille A. Lumley, Maria F.M. Braga
Publikováno v:
Neurobiology of Disease, Vol 200, Iss , Pp 106633- (2024)
The triggers of status epilepticus (SE) in non-epileptic patients can vary widely, from idiopathic causes to exposure to chemoconvulsants. Regardless of its etiology, prolonged SE can cause significant brain damage, commonly resulting in the developm
Externí odkaz:
https://doaj.org/article/a229ad7c53834fcdbd6242c1a93473f7
Autor:
Lucille A. Lumley, Brenda Marrero‐Rosado, Franco Rossetti, Caroline R. Schultz, Michael F. Stone, Jerome Niquet, Claude G. Wasterlain
Publikováno v:
Epilepsia Open, Vol 6, Iss 4, Pp 757-769 (2021)
Abstract Objective Cholinergic‐induced status epilepticus (SE) is associated with a loss of synaptic gamma‐aminobutyric acid A receptors (GABAAR) and an increase in N‐methyl‐D‐aspartate receptors (NMDAR) and amino‐3‐hydroxy‐5‐methyl
Externí odkaz:
https://doaj.org/article/8353077f8b364edd90a8daf425f335b3
Autor:
Lucille A. Lumley, Franco Rossetti, Marcio de Araujo Furtado, Brenda Marrero-Rosado, Caroline R. Schultz, Mark K. Schultz, Jerome Niquet, Claude G. Wasterlain
Publikováno v:
Data in Brief, Vol 27, Iss , Pp - (2019)
This article investigated the efficacy of the combination of antiepileptic drug therapy in protecting against soman-induced seizure severity, epileptogenesis and performance deficits. Adult male rats with implanted telemetry transmitters for continuo
Externí odkaz:
https://doaj.org/article/05c592851a2d4f11b2f42351c5b2da20
Female rats are less susceptible during puberty to the lethal effects of percutaneous exposure to VX
Publikováno v:
Toxicology Reports, Vol 3, Iss , Pp 895-899 (2016)
Nerve agents with low volatility such as VX are primarily absorbed through the skin when released during combat or a terrorist attack. The barrier function of the stratum corneum may be compromised during certain stages of development, allowing VX to
Externí odkaz:
https://doaj.org/article/3834084d687945afa1cc714650a7de07
Autor:
Jerome Niquet, Caroline R. Schultz, Brenda Marrero-Rosado, Franco Rossetti, Michael F. Stone, Claude G. Wasterlain, Lucille A. Lumley
Publikováno v:
Epilepsia Open, Vol 6, Iss 4, Pp 757-769 (2021)
Epilepsia Open
Epilepsia Open
Objective Cholinergic-induced status epilepticus (SE) is associated with a loss of synaptic gamma-aminobutyric acid A receptors (GABAA R) and an increase in N-methyl-D-aspartate receptors (NMDAR) and amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::888b700314b4f4ce5ef649e2f6874642
https://doaj.org/article/8353077f8b364edd90a8daf425f335b3
https://doaj.org/article/8353077f8b364edd90a8daf425f335b3
Autor:
Marcio de Araujo Furtado, Brenda Marrero-Rosado, Michael F. Stone, Erica Kundrick, Lucille A. Lumley, Caroline R. Schultz
Publikováno v:
Neurotoxicology
Cannabidiol, approved for treatment of pediatric refractory epilepsy, has anti-seizure effects in various animal seizure models. Chemical warfare nerve agents, including soman, are organophosphorus chemicals that can induce seizure and death if untre
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4e569ee3a5918d2776ec1fc215871b28
https://doi.org/10.1016/j.neuro.2020.12.002
https://doi.org/10.1016/j.neuro.2020.12.002
Autor:
Katie Walker, Linnzi K.M. Wright, Tsung-Ming Shih, Fu Du, Michael F. Stone, Zora-Maya Keith, Caroline R. Schultz, Lucille A. Lumley, Brenda Marrero-Rosado, Kimberly A. Whitten, Cindy Acon-Chen
Publikováno v:
Toxicology Reports, Vol 8, Iss, Pp 896-907 (2021)
Toxicology Reports
Toxicology Reports
Graphical abstract
Highlights • The median lethal dose of soman (GD) was estimated in adult male Göttingen minipigs. • GD exposure induces cholinesterase inhibition and behavioral seizure in minipigs. • GD induces neurodegeneration in vis
Highlights • The median lethal dose of soman (GD) was estimated in adult male Göttingen minipigs. • GD exposure induces cholinesterase inhibition and behavioral seizure in minipigs. • GD induces neurodegeneration in vis
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::757661aa0cf9bbfbadc91ef4471049fd
http://www.sciencedirect.com/science/article/pii/S2214750021000810
http://www.sciencedirect.com/science/article/pii/S2214750021000810
Autor:
Robyn B. Lee-Stubbs, Caroline R. Schultz, Lucille A. Lumley, Brenda Marrero-Rosado, Marcio de Araujo Furtado, Erica Kundrick, Michael F. Stone, Katie Walker
Publikováno v:
Ann N Y Acad Sci
Chemical warfare nerve agent exposure leads to status epilepticus (SE) that may progress to epileptogenesis and severe brain pathology when benzodiazepine treatment is delayed. We evaluated the dose–response effects of delayed midazolam on toxicity
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e5368ac9f2f25277a9abddfcf1f3bb06
https://doi.org/10.1111/nyas.14311
https://doi.org/10.1111/nyas.14311
Autor:
J.M. McGuire, Lucille A. Lumley, William T. Muse, Dennis B. Miller, Christopher E. Whalley, Marcio de Araujo Furtado, Brenda Marrero-Rosado, Michael F. Stone
Publikováno v:
Epilepsia Open
Epilepsia Open, Vol 4, Iss 3, Pp 382-396 (2019)
Epilepsia Open, Vol 4, Iss 3, Pp 382-396 (2019)
Objective Our objective was to evaluate the protective efficacy of the neurosteroid pregnanolone (3α‐hydroxy‐5β pregnan‐20‐one), a GABAA receptor‐positive allosteric modulator, as an adjunct to benzodiazepine therapy against the chemical
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0490527ae3e6eb1e7e36901e7404b5de
http://europepmc.org/articles/PMC6698686
http://europepmc.org/articles/PMC6698686
Autor:
Brenda Marrero-Rosado, Michael F. Stone, Lucille A. Lumley, C. Linn Cadieux, Caroline R. Schultz, Marcio de Araujo Furtado
Publikováno v:
International Journal of Molecular Sciences, Vol 22, Iss 1893, p 1893 (2021)
International Journal of Molecular Sciences
Volume 22
Issue 4
International Journal of Molecular Sciences
Volume 22
Issue 4
The identification of improved medical countermeasures against exposure to chemical warfare nerve agents (CWNAs), a class of organophosphorus compounds, is dependent on the choice of animal model used in preclinical studies. CWNAs bind to acetylcholi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e53550536bbd1ed3c06f07be15197820
https://www.mdpi.com/1422-0067/22/4/1893
https://www.mdpi.com/1422-0067/22/4/1893