Výsledky vyhledávání - "Lucilla Turco"

Detection, identification and quantification of a new de-fluorinated impurity in casopitant mesylate drug substance during late phase development: An analytical challenge involving a multidisciplinary approach

Autor: Damiano Papini, Lucilla Turco, Carla Marchioro, Ornella Curcuruto, Stefano Provera, Riet Dams, Damiano Castoldi, Luca Martini, Zadeo Cimarosti, Elena Bernabe, Anna Nicoletti

Publikováno v: Journal of Pharmaceutical and Biomedical Analysis. 54:67-73

During late phase development of the selective NK1 receptor antagonist casopitant mesylate, a de-fluorinated impurity was discovered and quantified by an orthogonal analytical approach, using NMR and LC–MS. A dedicated 19F NMR method was initially

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ae3c3966bf311dd0bad3d92f1a26d0f3
https://doi.org/10.1016/j.jpba.2010.08.010

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Application of LC-NMR and HR-NMR to the characterization of biphenyl impurities in the synthetic route development for vestipitant, a novel NK1 antagonist

Autor: Giuseppe Guercio, Carla Marchioro, Lucilla Turco, Stefano Provera, Laura Costa, Luca Martini

Publikováno v: Journal of Pharmaceutical and Biomedical Analysis. 53:389-395

Vestipitant (1) is a novel NK1 antagonist currently under investigation for the treatment of CNS disorders and emesis. The first synthetic step comprised a Grignard synthesis. An impurity was identified and initially expected to be a symmetric biphen

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::74748e67d5abb77f3bc1d3f797e0de07
https://doi.org/10.1016/j.jpba.2010.04.027

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An Efficient Scalable Route for the Synthesis of Enantiomerically Pure tert-Butyl-(1R,4S,6R)-4-(hydroxymethyl)-3-azabicyclo[4.1.0]heptane-3-carboxylate

Publikováno v: Organic Process Research & Development. 14:1239-1247

An efficient scalable route to synthesize the enantiomerically pure tert-butyl-(1R,4S,6R)-4-(hydroxymethyl)-3-azabicyclo[4.1.0]heptane-3-carboxylate is described. Compared to the original routes, significant improvements were made by using an innovat

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::cb19119ea9299a9302fec3bb306f634d
https://doi.org/10.1021/op100164v

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Overall Synthesis of GSK356278: Quick Delivery of a PDE4 Inhibitor Using a Fit-for-Purpose Approach

Autor: Paolo Stabile, Arianna Ribecai, Nicola Giubellina, Sara Rossi, Giuseppe Guercio, Lucilla Turco, Claudio Bismara, Riet Dams, Pieter Westerduin, Damiano Castoldi, Alessandro Lamonica, Anna Nicoletti, Stefano Provera

Publikováno v: Organic Process Research & Development. 14:1153-1161

The family of phosphodiesterase (PDE) enzymes hydrolyse cyclic nucleotides, cAMP and cGMP, leading to their inactivation as intracellular second messengers. Inhibition of these enzymes leads to an elevation of levels of cyclic nucleotides in the cell

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::f09bdd808d853a70a14a804585b37e4f
https://doi.org/10.1021/op1001148

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Identification of a Manufacturing Route of Novel CRF-1 Antagonists Containing a 2,3-Dihydro-1H-pyrrolo[2,3-b]pyridine Moiety

Autor: Angelo M. Manzo, Arianna Ribecai, Stefano Provera, Sara Rossi, Monica Delpogetto, Simone Guelfi, Pieter Westerduin, Marie Hourdin, Alcide Perboni, Sergio Bacchi, Lucilla Turco, Paolo Stabile

Publikováno v: Organic Process Research & Development. 14:895-901

A case study on the synthesis of novel CRF-1 antagonists containing the 2,3-dihydro-1H-pyrrolo[2,3-b]pyridine moiety is presented. The development of ever more efficient synthetic routes allowed th...

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::57f8ffcccb3566e72760c84047875f68
https://doi.org/10.1021/op100147h

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Highly efficient and safe procedure for the synthesis of aryl 1,2,3-triazoles from aromatic amine in a continuous flow reactor

Autor: Damiano Cancogni, Pieter Westerduin, Lucilla Turco, Federica Stazi, Sergio Bacchi

Publikováno v: Tetrahedron Letters. 51:5385-5387

The Letter reports a safe and reliable synthesis of aryl 1,2,3-triazoles from the corresponding anilines via intermediate aryl azides, using a continuous process. The method was applied to a variety of substrates with good to excellent yields, withou

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::d4c8337110d990b428cdaa888fadb461
https://doi.org/10.1016/j.tetlet.2010.07.149

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Application of LC-NMR to the identification of bulk drug impurities in NK1 antagonist GW597599 (vestipitant)

Autor: Ornella Curcuruto, Giuseppe Alvaro, Giuseppe Guercio, Carla Marchioro, T. Rossi, Stefano Provera, Lucilla Turco

Publikováno v: Magnetic resonance in chemistry : MRC. 48(7)

Liquid chromatography-NMR (LC-NMR) spectroscopy was used to obtain detailed information regarding the structure of the major bulk drug impurities present in GW597599 (vestipitant). The one-dimensional (1)H LC-NMR experiments were performed in both co

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::392b260af84380fe8abd4e6faaba0302
https://pubmed.ncbi.nlm.nih.gov/20535779

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A multi-technique approach using LC-NMR, LC-MS, semi-preparative HPLC, HR-NMR and HR-MS for the isolation and characterization of low-level unknown impurities in GW876008, a novel corticotropin-release factor 1 antagonist

Autor: Luca Rovatti, Lucilla Turco, Arianna Ribecai, Sergio Bacchi, Stefano Provera, Damiano Papini, Anna Mingardi, Simone Guelfi, Sebastiano Mozzo, Carla Marchioro, Alberto Spezzaferri

Publikováno v: Journal of pharmaceutical and biomedical analysis. 53(3)

A multi-technique approach was applied in order to fully characterize four low-level unknown impurities of GW876008, a novel CRF(1) receptor antagonist. Liquid chromatography (LC)-NMR spectroscopy was used in combination with LC-MS to obtain detailed

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fff54ac3c7c4c6ffe716540af5b293d8
https://pubmed.ncbi.nlm.nih.gov/20619567

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NMR spectroscopy and surface tension measurements applied to the study of self-association of casopitant mesylate, a novel NK1 antagonist

Autor: Stefania Beato, Zadeo Cimarosti, Andrea Casazza, Stefano Provera, Carla Marchioro, Grazia Caivano, Lucilla Turco

Publikováno v: Journal of pharmaceutical and biomedical analysis. 54(1)

The aggregation behaviour of casopitant mesylate, a new NK1 antagonist drug, was investigated by means of NMR spectroscopy and surface tension measurements. The critical micelle concentration (CMC) in glycine buffer at pH 3.5 was determined by analyz

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::931477d386bdabeb5f73b26312d3a192
https://pubmed.ncbi.nlm.nih.gov/20813479

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