p63 at the Crossroads between Stemness and Metastasis in Breast Cancer

Autor: Veronica Gatti, Lucilla Bongiorno-Borbone, Claudia Fierro, Margherita Annicchiarico-Petruzzelli, Gerry Melino, Angelo Peschiaroli

Publikováno v: International Journal of Molecular Sciences, Vol 20, Iss 11, p 2683 (2019)

After lung cancer, breast cancer (BC) is the most frequent cause of cancer death among women, worldwide. Although advances in screening approaches and targeted therapeutic agents have decreased BC incidence and mortality, over the past five years, tr

Externí odkaz: https://doaj.org/article/cd149ee55ede4c7c9479e15add8a5d22

A novel oral micellar fenretinide formulation with enhanced bioavailability and antitumour activity against multiple tumours from cancer stem cells

Autor: Giovanni Sette, Lello Zolla, Gerry Melino, Angelo Peschiaroli, Federica Francescangeli, Mariella Ferrari, Maria Laura De Angelis, Cristina Matteo, Ezia Bello, Antonio Di Virgilio, Massimo Zucchetti, Valentina Salvati, Mario Falchi, Isabella Orienti, Marta Baiocchi, Adriana Eramo, Ruggero De Maria, Ann Zeuner, Lucilla Bongiorno-Borbone

Publikováno v: Journal of Experimental & Clinical Cancer Research : CR
Journal of experimental & clinical cancer research (Online) 38 (2019). doi:10.1186/s13046-019-1383-9
info:cnr-pdr/source/autori:Orienti, Isabella; Salvati, Valentina; Sette, Giovanni; Zucchetti, Massimo; Bongiorno-Borbone, Lucilla; Peschiaroli, Angelo; Zolla, Lello; Francescangeli, Federica; Ferrari, Mariella; Matteo, Cristina; Bello, Ezia; Di Virgilio, Antonio; Falchi, Mario; De Angelis, Maria Laura; Baiocchi, Marta; Melino, Gerry; De Maria, Ruggero; Zeuner, Ann; Eramo, Adriana/titolo:A novel oral micellar fenretinide formulation with enhanced bioavailability and antitumour activity against multiple tumours from cancer stem cells/doi:10.1186%2Fs13046-019-1383-9/rivista:Journal of experimental & clinical cancer research (Online)/anno:2019/pagina_da:/pagina_a:/intervallo_pagine:/volume:38
Journal of Experimental & Clinical Cancer Research, Vol 38, Iss 1, Pp 1-17 (2019)

Background An increasing number of anticancer agents has been proposed in recent years with the attempt to overcome treatment-resistant cancer cells and particularly cancer stem cells (CSC), the major culprits for tumour resistance and recurrence. Ho

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9eb4fc89e25feeb0fbe91e57fe07b777
http://hdl.handle.net/11573/1336618

ΔNp63-mediated regulation of hyaluronic acid metabolism and signaling supports HNSCC tumorigenesis

Autor: Lucia Anemone, Gerry Melino, Giovina Ruberti, Veronica Gatti, Lucilla Bongiorno-Borbone, Huiqing Zhou, Alessandro Mauriello, Karen H. Vousden, Elke Markert, Claudia Fierro, Angelo Peschiaroli, Dario Presutti, Mirco Compagnone

Publikováno v: Proceedings of the National Academy of Sciences of the United States of America 114 (2017): 13254–13259. doi:10.1073/pnas.1711777114
info:cnr-pdr/source/autori:Compagnone, Mirco; Gatti, Veronica; Presutti, Dario; Ruberti, Giovina; Fierro, Claudia; Markert, Elke Katrin; Vousden, Karen H.; Zhou, Huiqing; Mauriello, Alessandro; Anemone, Lucia; Bongiorno-Borbone, Lucilla; Melino, Gerry; Peschiaroli, Angelo/titolo:Delta Np63-mediated regulation of hyaluronic acid metabolism and signaling supports HNSCC tumorigenesis/doi:10.1073%2Fpnas.1711777114/rivista:Proceedings of the National Academy of Sciences of the United States of America/anno:2017/pagina_da:13254/pagina_a:13259/intervallo_pagine:13254–13259/volume:114
Proceedings of the National Academy of Sciences USA, 114, 50, pp. 13254-13259
Proceedings of the National Academy of Sciences USA, 114, 13254-13259

Head and neck squamous cell carcinoma (HNSCC) is the sixth most common cancer worldwide, and several molecular pathways that underlie the molecular tumorigenesis of HNSCC have been identified. Among them, amplification or overexpression of Delta Np63

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1fa29c721f444887bacfb0436f25dc09
http://hdl.handle.net/2108/204065

p63 controls cell migration and invasion by transcriptional regulation of MTSS1

Autor: Alexey V. Antonov, E K Markert, J H Zhou, Angelo Peschiaroli, Gennaro Melino, Mirco Compagnone, Margherita Annicchiarico-Petruzzelli, Arianna Giacobbe, Lucilla Bongiorno-Borbone

Publikováno v: Oncogene (Basingstoke) 35 (2016): 1602–1608. doi:10.1038/onc.2015.230
info:cnr-pdr/source/autori:Giacobbe, A.; Compagnone, M.; Bongiorno-Borbone, L.; Antonov, A.; Markert, E. K.; Zhou, J. H.; Annicchiarico-Petruzzelli, M.; Melino, G.; Peschiaroli, A./titolo:p63 controls cell migration and invasion by transcriptional regulation of MTSS1/doi:10.1038%2Fonc.2015.230/rivista:Oncogene (Basingstoke)/anno:2016/pagina_da:1602/pagina_a:1608/intervallo_pagine:1602–1608/volume:35

Metastasis is a multistep cell-biological process, which is orchestrated by many factors, including metastasis activators and suppressors. Metastasis Suppressor 1 (MTSS1) was originally identified as a metastasis suppressor protein whose expression i

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9758958bf2ee5ed020ab57cb0259107b
http://hdl.handle.net/2108/239692

FLASH is an essential component of Cajal bodies

Autor: Eliana Munarriz, Daniela Barcaroli, Richard A. Knight, Michael H Neale, V De Laurenzi, Gerry Melino, E. Fava, T. M. Smith, A E Sayan, J. M. McWilliam, David Dinsdale, Lucilla Bongiorno-Borbone, Marco Ranalli

Publikováno v: Proceedings of the National Academy of Sciences. 103:14802-14807

Cajal bodies are small nuclear organelles with a number of nuclear functions. Here we show that FLICE-associated huge protein (FLASH), originally described as a component of the apoptosis signaling pathway, is mainly localized in Cajal bodies and is

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1933264924a19b966280e5b06ec29714
https://doi.org/10.1073/pnas.0604225103