Zobrazeno 1 - 10
of 33
pro vyhledávání: '"Lucile Moynié"'
Autor:
Lachlan P. Deimel, Lucile Moynié, Guoxuan Sun, Viliyana Lewis, Abigail Turner, Charles J. Buchanan, Sean A. Burnap, Mikhail Kutuzov, Carolin M. Kobras, Yana Demyanenko, Shabaz Mohammed, Mathew Stracy, Weston B. Struwe, Andrew J. Baldwin, James Naismith, Benjamin G. Davis, Quentin J. Sattentau
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-12 (2024)
Abstract Many archetypal and emerging classes of small-molecule therapeutics form covalent protein adducts. In vivo, both the resulting conjugates and their off-target side-conjugates have the potential to elicit antibodies, with implications for all
Externí odkaz:
https://doaj.org/article/cfce8b6432ac440bba75dc9b6023863a
Autor:
Lachlan P. Deimel, Lucile Moynié, Guoxuan Sun, Viliyana Lewis, Abigail Turner, Charles J. Buchanan, Sean A. Burnap, Mikhail Kutuzov, Carolin M. Kobras, Yana Demyanenko, Shabaz Mohammed, Mathew Stracy, Weston B. Struwe, Andrew J. Baldwin, James Naismith, Benjamin G. Davis, Quentin J. Sattentau
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-2 (2024)
Externí odkaz:
https://doaj.org/article/836c4e00b4f84b94874a2256fdbc25ff
Autor:
Jiandong Huo, Halina Mikolajek, Audrey Le Bas, Jordan J. Clark, Parul Sharma, Anja Kipar, Joshua Dormon, Chelsea Norman, Miriam Weckener, Daniel K. Clare, Peter J. Harrison, Julia A. Tree, Karen R. Buttigieg, Francisco J. Salguero, Robert Watson, Daniel Knott, Oliver Carnell, Didier Ngabo, Michael J. Elmore, Susan Fotheringham, Adam Harding, Lucile Moynié, Philip N. Ward, Maud Dumoux, Tessa Prince, Yper Hall, Julian A. Hiscox, Andrew Owen, William James, Miles W. Carroll, James P. Stewart, James H. Naismith, Raymond J. Owens
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-18 (2021)
Neutralizing nanobodies (Nb) are of considerable interest as therapeutic agents for COVID-19 treatment. Here, the authors functionally and structurally characterize Nbs that bind with high affinity to the receptor binding domain of the SARS-CoV-2 spi
Externí odkaz:
https://doaj.org/article/d505e344aed84336a3d7f7d369c5238a
Autor:
Lucile Moynié, Stefan Milenkovic, Gaëtan L. A. Mislin, Véronique Gasser, Giuliano Malloci, Etienne Baco, Rory P. McCaughan, Malcolm G. P. Page, Isabelle J. Schalk, Matteo Ceccarelli, James H. Naismith
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-14 (2019)
Bacteria produce small iron-binding molecules called siderophores, which are recognised by outer-membrane transporters. Here, the authors show that a Pseudomonas transporter recognises the siderophore enterobactin using extracellular loops distant fr
Externí odkaz:
https://doaj.org/article/8945e5c4fd1a454a9808f2cc55ad41dc
Autor:
Lucile Moynié, Ilaria Serra, Mariano A Scorciapino, Emilia Oueis, Malcolm GP Page, Matteo Ceccarelli, James H Naismith
Publikováno v:
eLife, Vol 7 (2018)
New strategies are urgently required to develop antibiotics. The siderophore uptake system has attracted considerable attention, but rational design of siderophore antibiotic conjugates requires knowledge of recognition by the cognate outer-membrane
Externí odkaz:
https://doaj.org/article/75667c88bc5a46d98e1880560aea680d
Autor:
Florian Georgescauld, Lucile Moynié, Johann Habersetzer, Laura Cervoni, Iulia Mocan, Tudor Borza, Pernile Harris, Alain Dautant, Ioan Lascu
Publikováno v:
PLoS ONE, Vol 8, Iss 3, p e57867 (2013)
Most nucleoside diphosphate kinases (NDPKs) are hexamers. The C-terminal tail interacting with the neighboring subunits is crucial for hexamer stability. In the NDPK from Mycobacterium tuberculosis (Mt) this tail is missing. The quaternary structure
Externí odkaz:
https://doaj.org/article/9c4941e5b62e43ea9a9b1fc3572e125e
Autor:
Robert J. Watson, Oliver Carnell, Jordan J. Clark, Francisco J. Salguero, Tessa Prince, William James, Michael J. Elmore, Miriam Weckener, Philip N. Ward, Audrey Le Bas, Chelsea Norman, Susan A. Fotheringham, Raymond J. Owens, Yper Hall, Parul Sharma, James H. Naismith, Adam Harding, Karen R. Buttigieg, Andrew Owen, Peter J. Harrison, Lucile Moynié, Jiandong Huo, Anja Kipar, Miles W. Carroll, Daniel K. Clare, James P. Stewart, Didier Ngabo, H. Mikolajek, Daniel Knott, Maud Dumoux, Joshua Dormon, Julia A. Tree, Julian A. Hiscox
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-18 (2021)
Nature Communications
Nature Communications
SARS-CoV-2 remains a global threat to human health particularly as escape mutants emerge. There is an unmet need for effective treatments against COVID-19 for which neutralizing single domain antibodies (nanobodies) have significant potential. Their
Autor:
Lucile, Moynié, Françoise, Hoegy, Stefan, Milenkovic, Mathilde, Munier, Aurélie, Paulen, Véronique, Gasser, Aline L, Faucon, Nicolas, Zill, James H, Naismith, Matteo, Ceccarelli, Isabelle J, Schalk, Gaëtan L A, Mislin
Publikováno v:
ACS infectious diseases. 8(9)
Enterobactin (ENT) is a tris-catechol siderophore used to acquire iron by multiple bacterial species. These ENT-dependent iron uptake systems have often been considered as potential gates in the bacterial envelope through which one can shuttle antibi
Autor:
Michael L. Knight, Pramila Rijal, Maud Dumoux, David I. Stuart, Loic Carrique, J. Huo, Lucile Moynié, Michael J. Elmore, Philip N. Ward, Miriam Weckener, Shah Pnm., Javier Gilbert-Jaramillo, Daniel K. Clare, A. Le Bas, Miles W. Carroll, Julia A. Tree, Reinis R. Ruza, Yuguang Zhao, Jingshan Ren, Tomas Malinauskas, Karen R. Buttigieg, H. Mikolajek, Raymond J. Owens, V K Vogirala, William James, James H. Naismith, Duyvesteyn Hme., Julika Radecke, Alain Townsend, Tiong Kit Tan, Naomi Coombes, D. Zhou, Peter J. Harrison
Publikováno v:
Nature Structural & Molecular Biology
The SARS-CoV-2 virus is more transmissible than previous coronaviruses and causes a more serious illness than influenza. The SARS-CoV-2 receptor binding domain (RBD) of the spike protein binds to the human angiotensin-converting enzyme 2 (ACE2) recep
Autor:
Lucile Moynié, Julien Godet, Véronique Gasser, Françoise Hoegy, Mathilde Munier, Yves Mély, Gaëtan L. A. Mislin, Quentin Perraud, Isabelle J. Schalk, James H. Naismith
Publikováno v:
ACS Chemical Biology
ACS Chemical Biology, American Chemical Society, 2018, 13 (9), pp.2603-2614. ⟨10.1021/acschembio.8b00543⟩
ACS Chemical Biology, American Chemical Society, 2018, 13 (9), pp.2603-2614. ⟨10.1021/acschembio.8b00543⟩
Enterobactin (ENT) is a siderophore (iron-chelating compound) produced by Escherichia coli to gain access to iron, an indispensable nutrient for bacterial growth. ENT is used as an exosiderophore by Pseudomonas aeruginosa with transport of ferri-ENT