Zobrazeno 1 - 10
of 65
pro vyhledávání: '"Lucile Astorgues‐Xerri"'
Autor:
Cindy Neuzillet, Rémy Nicolle, Jérôme Raffenne, Annemilaï Tijeras‐Raballand, Alexia Brunel, Lucile Astorgues‐Xerri, Sophie Vacher, Floriane Arbateraz, Marjorie Fanjul, Marc Hilmi, Rémi Samain, Christophe Klein, Aurélie Perraud, Vinciane Rebours, Muriel Mathonnet, Ivan Bièche, Hemant Kocher, Jérôme Cros, Corinne Bousquet
Publikováno v:
The Journal of Pathology. 258:408-425
Cancer-associated fibroblasts (CAFs) are orchestrators of the pancreatic ductal adenocarcinoma (PDAC) microenvironment. Previously we described four CAF subtypes with specific molecular and functional features. Here, we have refined our CAF subtype s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1450bcbbd783e222a4a8474594bb4bc5
https://doi.org/10.1002/path.6011
https://doi.org/10.1002/path.6011
Autor:
Johannes H. Schulte, Esteban Cvitkovic, Angelika Eggert, Maria E. Riveiro, Lucile Astorgues-Xerri, Alexander Schramm, Natalie Sadowski, Sven Lindner, Kathy Astrahanseff, Annika Spruessel, Lukas Heukamp, Alexandra Florin, Katleen De Preter, Frank Westermann, Maike Nortmeyer, Emma Bell, Simon Schäfers, Frank Speleman, Richard Koche, Anneleen Beckers, Andrea Odersky, Kristina Althoff, Anton Henssen
Differentially expressed genes in IMR5 cells after OTX015 and JQ1 treatment respectively
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c7cd3ec694515f6a093660738eaa9330
https://doi.org/10.1158/1078-0432.22458741.v1
https://doi.org/10.1158/1078-0432.22458741.v1
Autor:
Johannes H. Schulte, Esteban Cvitkovic, Angelika Eggert, Maria E. Riveiro, Lucile Astorgues-Xerri, Alexander Schramm, Natalie Sadowski, Sven Lindner, Kathy Astrahanseff, Annika Spruessel, Lukas Heukamp, Alexandra Florin, Katleen De Preter, Frank Westermann, Maike Nortmeyer, Emma Bell, Simon Schäfers, Frank Speleman, Richard Koche, Anneleen Beckers, Andrea Odersky, Kristina Althoff, Anton Henssen
Mechanisms of reduced cell viability induced by OTX015 are cell line dependent. OTX015 reduces cell proliferation over time and induces cell cycle changes as well as apoptosis. (a) Representative photomicrographs of neuroblastoma cell lines treated w
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0f6c21717502a0e406b5de6278290afd
https://doi.org/10.1158/1078-0432.22458717
https://doi.org/10.1158/1078-0432.22458717
Autor:
Johannes H. Schulte, Esteban Cvitkovic, Angelika Eggert, Maria E. Riveiro, Lucile Astorgues-Xerri, Alexander Schramm, Natalie Sadowski, Sven Lindner, Kathy Astrahanseff, Annika Spruessel, Lukas Heukamp, Alexandra Florin, Katleen De Preter, Frank Westermann, Maike Nortmeyer, Emma Bell, Simon Schäfers, Frank Speleman, Richard Koche, Anneleen Beckers, Andrea Odersky, Kristina Althoff, Anton Henssen
All H3K27Ac peaks called in non-promoter regions in IMR5
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0c0bdb3202921740e4a27fb7232c3f5c
https://doi.org/10.1158/1078-0432.22458729.v1
https://doi.org/10.1158/1078-0432.22458729.v1
Autor:
Johannes H. Schulte, Esteban Cvitkovic, Angelika Eggert, Maria E. Riveiro, Lucile Astorgues-Xerri, Alexander Schramm, Natalie Sadowski, Sven Lindner, Kathy Astrahanseff, Annika Spruessel, Lukas Heukamp, Alexandra Florin, Katleen De Preter, Frank Westermann, Maike Nortmeyer, Emma Bell, Simon Schäfers, Frank Speleman, Richard Koche, Anneleen Beckers, Andrea Odersky, Kristina Althoff, Anton Henssen
OTX015 has no significant effect on non-malignant human fibroblasts. (a) Representative pictures of human fibroblasts treated for 72 h with 500 nM OTX015 or DMSO control. Scale bar=100 µm. (b) Growth of fibroblasts treated with 500 nM OTX015 (black)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::079d20d24933361e5347a563449a502c
https://doi.org/10.1158/1078-0432.22458723
https://doi.org/10.1158/1078-0432.22458723
Autor:
Johannes H. Schulte, Esteban Cvitkovic, Angelika Eggert, Maria E. Riveiro, Lucile Astorgues-Xerri, Alexander Schramm, Natalie Sadowski, Sven Lindner, Kathy Astrahanseff, Annika Spruessel, Lukas Heukamp, Alexandra Florin, Katleen De Preter, Frank Westermann, Maike Nortmeyer, Emma Bell, Simon Schäfers, Frank Speleman, Richard Koche, Anneleen Beckers, Andrea Odersky, Kristina Althoff, Anton Henssen
GSEA of gene sets describing general cellular processes after treatment with OTX015 and/or JQ1(GSEA, Broad institute)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::342c4514be8e32a13a17e6c8666271cc
https://doi.org/10.1158/1078-0432.22458735.v1
https://doi.org/10.1158/1078-0432.22458735.v1
Autor:
Johannes H. Schulte, Esteban Cvitkovic, Angelika Eggert, Maria E. Riveiro, Lucile Astorgues-Xerri, Alexander Schramm, Natalie Sadowski, Sven Lindner, Kathy Astrahanseff, Annika Spruessel, Lukas Heukamp, Alexandra Florin, Katleen De Preter, Frank Westermann, Maike Nortmeyer, Emma Bell, Simon Schäfers, Frank Speleman, Richard Koche, Anneleen Beckers, Andrea Odersky, Kristina Althoff, Anton Henssen
BET inhibition preferentially disrupts expression of genes associated with super-enhancers. (a) ChIP-seq profiles for H3K27Ac binding at representative super-enhancer-associated gene loci, including MYCN, NCOR2, BCOR and GLI2, in MYCN-amplified IMR-5
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cde9e59bc7ca07c5c3ec4d2b98e90f35
https://doi.org/10.1158/1078-0432.22458705.v1
https://doi.org/10.1158/1078-0432.22458705.v1
Autor:
Johannes H. Schulte, Esteban Cvitkovic, Angelika Eggert, Maria E. Riveiro, Lucile Astorgues-Xerri, Alexander Schramm, Natalie Sadowski, Sven Lindner, Kathy Astrahanseff, Annika Spruessel, Lukas Heukamp, Alexandra Florin, Katleen De Preter, Frank Westermann, Maike Nortmeyer, Emma Bell, Simon Schäfers, Frank Speleman, Richard Koche, Anneleen Beckers, Andrea Odersky, Kristina Althoff, Anton Henssen
GSEA of cancer gene sets after treatment with OTX015 and/or JQ1(GSEA, Broad institute)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8019254c454179edf44c85046656f67a
https://doi.org/10.1158/1078-0432.22458738.v1
https://doi.org/10.1158/1078-0432.22458738.v1
Autor:
Johannes H. Schulte, Esteban Cvitkovic, Angelika Eggert, Maria E. Riveiro, Lucile Astorgues-Xerri, Alexander Schramm, Natalie Sadowski, Sven Lindner, Kathy Astrahanseff, Annika Spruessel, Lukas Heukamp, Alexandra Florin, Katleen De Preter, Frank Westermann, Maike Nortmeyer, Emma Bell, Simon Schäfers, Frank Speleman, Richard Koche, Anneleen Beckers, Andrea Odersky, Kristina Althoff, Anton Henssen
BET bromodomain inhibition leads to disruption of MYCN driven gene-expression programs even at high levels of MYCN. (a) Enrichment of the published gene expression signature for JQ1-treated human MYCN-amplified neuroblastoma cell lines (11) in differ
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5f15b6f946f7d96e97df919886734c08
https://doi.org/10.1158/1078-0432.22458708
https://doi.org/10.1158/1078-0432.22458708
Autor:
Johannes H. Schulte, Esteban Cvitkovic, Angelika Eggert, Maria E. Riveiro, Lucile Astorgues-Xerri, Alexander Schramm, Natalie Sadowski, Sven Lindner, Kathy Astrahanseff, Annika Spruessel, Lukas Heukamp, Alexandra Florin, Katleen De Preter, Frank Westermann, Maike Nortmeyer, Emma Bell, Simon Schäfers, Frank Speleman, Richard Koche, Anneleen Beckers, Andrea Odersky, Kristina Althoff, Anton Henssen
Purpose: Targeting BET proteins was previously shown to have specific antitumoral efficacy against MYCN-amplified neuroblastoma. We here assess the therapeutic efficacy of the BET inhibitor, OTX015, in preclinical neuroblastoma models and extend the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::564e2497e5310f69a9afa32ffba42ce0
https://doi.org/10.1158/1078-0432.c.6524022.v1
https://doi.org/10.1158/1078-0432.c.6524022.v1