Výsledky vyhledávání - "Lucila Isabel Hinrichsen"

Effect of sex and genotype of the host on the anthelmintic efficacy of albendazole microcrystals, in the CBi-IGE Trichinella infection murine model

Autor: Ana Victoria Codina, Darío Leonardi, María D. Vasconi, Lucila Isabel Hinrichsen, Maria Celina Lamas, Josefina Priotti

Publikováno v: Parasitology. 148:1545-1553

Albendazole (ABZ) is an anthelmintic pharmaceutical commonly used in the treatment of nematode infections. It is a Class II drug poorly water-soluble, with very low bioavailability, a feature particularly limiting to treat the trichinellosis chronic

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::dbe0ca6b014863d1cf444a3f4c584562
https://doi.org/10.1017/s0031182021001128

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Effect of Genotype and Sex of the Host on the Bioavailability of Novel Albendazole Microcrystals Based on Chitosan and Cellulose Derivatives

Autor: María D. Vasconi, Josefina Priotti, Maria Celina Lamas, Ana Victoria Codina, Darío Leonardi, Lucila Isabel Hinrichsen

Publikováno v: AAPS PharmSciTech. 21(5)

Albendazole (ABZ), an anthelmintic compound widely used in the treatment of systemic nematode infections, is included in the list of class II drugs based on the Biopharmaceutical Classification System. ABZ has limited effectiveness due to its poor wa

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::25c945ffb68b03126a3abef8d8236e07
https://pubmed.ncbi.nlm.nih.gov/32435903

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Synthesis and characterization of a new cyclodextrin derivative with improved properties to design oral dosage forms

Autor: María D. Vasconi, Lucila Isabel Hinrichsen, Maria Celina Lamas, Ana Victoria Codina, Josefina Priotti, Ariel D. Quiroga, Darío Leonardi, Agustina García

This work aimed to synthesize a novel β-cyclodextrin derivative, itaconyl-β-cyclodextrin to evaluate whether albendazole inclusion complexes with the new β-cyclodextrin derivative-improved albendazole dissolution efficiency and its anthelminthic a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8e9ea18c7a1f9f77112eda356c42b09e
http://link.springer.com/10.1007/s13346-018-0591-8

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Phenotypic Characterization of the Response to Infection with Trichinella spiralis in Genetically Defined Mouse Lines of the CBi-IGE Stock

Autor: Ana Victoria Codina, Paula Indelman, María D. Vasconi, Ricardo José Di Masso, Griselda Bertorini, Lucila Isabel Hinrichsen

Publikováno v: Open Journal of Veterinary Medicine. :111-122

Trichinella spiralis (T. spiralis), which is a cosmopolitan nematode that infects humans among other species, presents a complex host-parasite relationship that hinders the development of tools to eradicate the parasitosis. The aim of this research w

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::50531c6b83ae15526c183f0f68f1033b
https://doi.org/10.4236/ojvm.2015.55015

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Combined calcitriol and menadione reduces experimental murine triple negative breast tumor

Autor: Valeria Rodríguez, Solange Guizzardi, Viviana R. Rozados, Gabriela Picotto, Nori Tolosa de Talamoni, David Cremonezzi, Lucila Isabel Hinrichsen, Luciana Paola Bohl

Publikováno v: CONICET Digital (CONICET)
Consejo Nacional de Investigaciones Científicas y Técnicas
instacron:CONICET

Background Calcitriol (D) or 1,25(OH)2D3 inhibits the growth of several tumor cells including breast cancer cells, by activating cell death pathways. Menadione (MEN), a glutathione-depleting compound, may be used to potentiate the antiproliferative a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1556db5fc8b1a243fc759494cce8d97d
https://pubmed.ncbi.nlm.nih.gov/28750356

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Phenotypic differences on the outcome of the host–parasite relationship: Behavior of mice of the CBi stock in natural and experimental infections

Autor: P. Malfante, Silvia Revelli, R. J. Di Masso, Lucila Isabel Hinrichsen, María D. Vasconi, M. T. Font, Claudio Giudici, A. Bassi

Publikováno v: Veterinary Parasitology. 153:157-163

Investigation of defined animal models may help to elucidate the role of the host genetic background in the development and establishment of a parasitic infection. Four lines of mice obtained by disruptive selection for body conformation (CBi+, CBi�

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5469501d8b50ef578fbadc1ce332846e
https://doi.org/10.1016/j.vetpar.2008.01.019

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Novel albendazole formulations given during the intestinal phase of Trichinella spiralis infection reduce effectively parasitic muscle burden in mice

Autor: María D. Vasconi, Agustina García, Lucila Isabel Hinrichsen, María G. Barrera, Ricardo José Di Masso, Gisela Noemi Piccirilli, Maria Celina Lamas, Darío Leonardi

Publikováno v: Parasitology International. 62:568-570

Trichinellosis is a zoonotic disease affecting people all over the world, for which there is no speedy and reliable treatment. Albendazole (ABZ), an inexpensive benzimidazole used in oral chemotherapy against helminthic diseases, has a broad spectrum

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5ee81acff1026961d0721fb4fd53d9ab
https://doi.org/10.1016/j.parint.2013.08.009

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Efficacy of albendazole:β-cyclodextrin citrate in the parenteral stage of Trichinella spiralis infection

Autor: María D. Vasconi, Ana Victoria Codina, Darío Leonardi, Lucila Isabel Hinrichsen, Agustina García, Maria Celina Lamas, Ricardo José Di Masso

Publikováno v: CONICET Digital (CONICET)
Consejo Nacional de Investigaciones Científicas y Técnicas
instacron:CONICET

Albendazole–β-cyclodextrin citrate (ABZ:C-β-CD) inclusion complex in vivo antiparasitic activity was evaluated in the parenteral phase of Trichinella spiralis infection in mice. An equimolar complex of ABZ:C-β-CD was prepared by spray-drying and

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2fa462eb41b4332bc1d604f126b70b0c
https://pubmed.ncbi.nlm.nih.gov/25790725

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Characterization of albendazole-randomly methylated-β-cyclodextrin inclusion complex and in vivo evaluation of its antihelmitic activity in a murine model of Trichinellosis

Autor: Agustina García, María D. Vasconi, Maria Celina Lamas, Darío Leonardi, Lucila Isabel Hinrichsen

Publikováno v: PLoS ONE
PLoS ONE, Vol 9, Iss 11, p e113296 (2014)
CONICET Digital (CONICET)
Consejo Nacional de Investigaciones Científicas y Técnicas
instacron:CONICET

Albendazole is a benzimidazole carbamate extensively used in oral chemotherapy against intestinal parasites, due to its broad spectrum activity, good tolerance and low cost. However, the drug has the disadvantage of poor bioavailability due to its ve

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::caeaa6404ae89cb4247cde4cd55ceb69
https://pubmed.ncbi.nlm.nih.gov/25406084

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