The dual-specificity kinase DYRK1A interacts with the Hepatitis B virus genome and regulates the production of viral RNA.

Autor: Pastor, Florentin¹ (AUTHOR), Charles, Emilie¹ (AUTHOR), Di Vona, Chiara^2,3 (AUTHOR), Chapelle, Maëlys¹ (AUTHOR), Rivoire, Michel⁴ (AUTHOR), Passot, Guillaume⁵ (AUTHOR), Chabot, Benoit⁶ (AUTHOR), de la Luna, Susana^2,3 (AUTHOR), Lucifora, Julie¹ (AUTHOR), Durantel, David¹ (AUTHOR), Salvetti, Anna¹ (AUTHOR) anna.salvetti@inserm.fr

Publikováno v: PLoS ONE. 10/15/2024, Vol. 19 Issue 10, p1-21. 21p.

Farnesoid X receptor alpha ligands inhibit HDV in vitro replication and virion infectivity.

Autor: Legrand AF; CIRI, Centre International de Recherche en Infectiologie, Team VIRIMI, Univ Lyon, Inserm, Université Claude Bernard Lyon 1, CNRS, ENS de Lyon, Lyon, France.; University of Lyon, Université Claude Bernard Lyon, Villeurbanne, France., Lucifora J; University of Lyon, Université Claude Bernard Lyon, Villeurbanne, France.; CIRI, Centre ge International de Recherche en Infectiologie, Team HepVir, Univ Lyon, Inserm Université Claude Bernard Lyon 1, CNRS, ENS de Lyon, Lyon, France., Lacombe B; CIRI, Centre International de Recherche en Infectiologie, Team VIRIMI, Univ Lyon, Inserm, Université Claude Bernard Lyon 1, CNRS, ENS de Lyon, Lyon, France., Ménard C; CIRI, Centre International de Recherche en Infectiologie, Team VIRIMI, Univ Lyon, Inserm, Université Claude Bernard Lyon 1, CNRS, ENS de Lyon, Lyon, France., Michelet M; INSERM U1052, Cancer Research Center of Lyon (CRCL), University of Lyon (UCBL1), CNRS Centre Léon Bérard, Lyon, France., Foca A; CIRI, Centre International de Recherche en Infectiologie, Team VIRIMI, Univ Lyon, Inserm, Université Claude Bernard Lyon 1, CNRS, ENS de Lyon, Lyon, France., Abrial P; CIRI, Centre International de Recherche en Infectiologie, Team VIRIMI, Univ Lyon, Inserm, Université Claude Bernard Lyon 1, CNRS, ENS de Lyon, Lyon, France., Salvetti A; University of Lyon, Université Claude Bernard Lyon, Villeurbanne, France., Rivoire M; INSERM Centre Léon Bérard (CLB), Lyon, France., Lotteau V; CIRI, Centre International de Recherche en Infectiologie, Team VIRIMI, Univ Lyon, Inserm, Université Claude Bernard Lyon 1, CNRS, ENS de Lyon, Lyon, France., Durantel D; University of Lyon, Université Claude Bernard Lyon, Villeurbanne, France.; CIRI, Centre ge International de Recherche en Infectiologie, Team HepVir, Univ Lyon, Inserm Université Claude Bernard Lyon 1, CNRS, ENS de Lyon, Lyon, France., André P; CIRI, Centre International de Recherche en Infectiologie, Team VIRIMI, Univ Lyon, Inserm, Université Claude Bernard Lyon 1, CNRS, ENS de Lyon, Lyon, France.; University of Lyon, Université Claude Bernard Lyon, Villeurbanne, France., Ramière C; CIRI, Centre International de Recherche en Infectiologie, Team VIRIMI, Univ Lyon, Inserm, Université Claude Bernard Lyon 1, CNRS, ENS de Lyon, Lyon, France.; University of Lyon, Université Claude Bernard Lyon, Villeurbanne, France.; Virology Laboratory, Hospices Civils de Lyon, Hôpital de la Croix-Rousse, Lyon, France.

Publikováno v: Hepatology communications [Hepatol Commun] 2023 Apr 14; Vol. 7 (5). Date of Electronic Publication: 2023 Apr 14 (Print Publication: 2023).

Highlights from the 2023 International Meeting on the Molecular Biology of Hepatitis B virus.

Autor: Allweiss L; Department of Internal Medicine, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.; German Center for Infection Research (DZIF), Braunschweig, Germany., Cohen C; Hepatitis B Foundation, Doylestown, PA, USA., Dias J; Laboratoire de Virologie Moléculaire, CNRS Université de Montpellier, Montpellier, France., Fumagalli V; Division of Immunology, Transplantation and Infectious Diseases, IRCCS San Raffaele Scientific Institute, 20132 Milan, Italy.; Vita-Salute San Raffaele University, 20132 Milan, Italy., Guo H; Department of Microbiology and Molecular Genetics; Cancer Virology Program, UPMC Hillman Cancer Center, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA., Harris JM; Nuffield Department of Medicine, University of Oxford, Oxford, UK., Hu J; Department of Microbiology and Immunology, The Pennsylvania State University College of Medicine, Hershey, PA, USA., Iannacone M; Division of Immunology, Transplantation and Infectious Diseases, IRCCS San Raffaele Scientific Institute, 20132 Milan, Italy.; Vita-Salute San Raffaele University, 20132 Milan, Italy., Isogawa M; Department of Virology II, National Institute of Infectious Diseases, Tokyo, Japan., Jeng WJ; Department of Gastroenterology and Hepatology, Chang Gung Memorial Hospital, Linkou Medical Center, Chang Gung University, Taoyuan, Taiwan, ROC., Kim KH; Department of Precision Medicine, School of Medicine, Sungkyunkwan University, Suwon, Republic of Korea., Kramvis A; Anna Kramvis Hepatitis Virus Diversity Research Unit, Department of Internal Medicine, School of Clinical Medicine, University of the Witwatersrand, Johannesburg, South Africa., Li W; National Institute of Biological Sciences, Beijing, PR China.; Tsinghua Institute of Multidisciplinary Biomedical Research, Tsinghua University, Beijing, PR China., Lucifora J; CIRI, Centre International de Recherche en Infectiologie, Univ Lyon, Inserm, U1111, Université Claude Bernard Lyon 1, CNRS, UMR5308, ENS de Lyon, F-69007, Lyon, France., Muramatsu M; Department of Infectious Disease Research, Institute of Biomedical Research and Innovation, Foundation for Biomedical Research and Innovation at Kobe, Kobe, Hyogo, Japan., Neuveut C; Laboratoire de Virologie Moléculaire, CNRS Université de Montpellier, Montpellier, France., Ploss A; Department of Molecular Biology, Princeton University, Princeton, NJ, USA., Pollicino T; Department of Clinical and Experimental Medicine, University Hospital of Messina, Messina, Italy., Protzer U; Institute of Virology, School of Medicine and Health, Technical University of Munich/Helmholtz Munich, Munich, Germany.; German Center for Infection Research (DZIF), Braunschweig, Germany., Tan A; Emerging Infectious Diseases, Duke-NUS Medical School, Singapore, Singapore., Tanaka Y; Department of Gastroenterology and Hepatology, Faculty of Life Sciences, Kumamoto University, Kumamoto 860-8556, Japan., Tu T; Storr Liver Centre, The Westmead Institute for Medical Research, The University of Sydney at Westmead Hospital, Westmead, NSW, Australia.; Centre for Infectious Diseases and Microbiology, Sydney Infectious Diseases Institute, The University of Sydney at Westmead Hospital, Westmead, NSW, Australia., Tsukuda S; Nuffield Department of Medicine, University of Oxford, Oxford, UK., Thimme R; Department of Medicine II, University Hospital Freiburg, Breisgau, Germany., Urban S; German Center for Infection Research (DZIF), Braunschweig, Germany., Watashi K; Research Center for Drug and Vaccine Development, National Institute of Infectious Diseases, Tokyo, Japan., Yuan Z; Key Lab of Medical Molecular Virology, Shanghai Medical College, Fudan University, Shanghai, PR China., Yeh SH; Graduate Institute of Microbiology, National Taiwan University College of Medicine, Taipei, Taiwan, ROC.; Department of Clinical Laboratory Sciences and Medical Biotechnology, National Taiwan University College of Medicine, Taipei, Taiwan, ROC., McKeating JA; Chinese Academy of Medical Sciences Oxford Institute, University of Oxford, Oxford, UK.; Nuffield Department of Medicine, University of Oxford, Oxford, UK., Revill PA; Victorian Infectious Diseases Reference Laboratory, Royal Melbourne Hospital at the Peter Doherty Institute for Infection and Immunity, Parkville, Victoria, Australia.; Department of Infectious Diseases, University of Melbourne, Parkville, Victoria, Australia.

Publikováno v: The Journal of general virology [J Gen Virol] 2024 May; Vol. 105 (5).

Modifying immune responses to adeno-associated virus vectors by capsid engineering.

Autor: Bentler M; Institute of Experimental Hematology, Hannover Medical School, 30625 Hannover, Germany., Hardet R; University of Rouen, INSERM, U1234, Pathophysiology Autoimmunity and Immunotherapy (PANTHER), Normandie University, 76000 Rouen, France., Ertelt M; Institute for Drug Discovery, University of Leipzig Medical Center, 04103 Leipzig, Germany.; Center for Scalable Data Analytics and Artificial Intelligence (ScaDS.AI), Dresden/Leipzig, Germany., Rudolf D; Laboratory for Vector Based Immunotherapy, Fraunhofer Institute for Cell Therapy and Immunology (IZI), 04103 Leipzig, Germany., Kaniowska D; Laboratory for Vector Based Immunotherapy, Fraunhofer Institute for Cell Therapy and Immunology (IZI), 04103 Leipzig, Germany.; Department of Medicine II, University Cancer Center Leipzig (UCCL), University of Leipzig Medical Center, 04103 Leipzig, Germany., Schneider A; Institute of Experimental Hematology, Hannover Medical School, 30625 Hannover, Germany., Vondran FWR; ReMediES, Department of General, Visceral and Transplant Surgery, Hannover Medical School, 30625 Hannover, Germany.; German Center for Infection Research (DZIF), Partner Site Hannover-Braunschweig, 38124 Braunschweig, Germany., Schoeder CT; Institute for Drug Discovery, University of Leipzig Medical Center, 04103 Leipzig, Germany., Delphin M; CIRI, Centre International de Recherche en Infectiologie, Université de Lyon, Inserm U1111, Université Claude Bernard Lyon 1, CNRS, UMR5308, ENS de Lyon, 69007 Lyon, France., Lucifora J; CIRI, Centre International de Recherche en Infectiologie, Université de Lyon, Inserm U1111, Université Claude Bernard Lyon 1, CNRS, UMR5308, ENS de Lyon, 69007 Lyon, France., Ott M; Department of Gastroenterology, Hepatology, and Endocrinology, Hannover Medical School, 30625 Hannover, Germany., Hacker UT; Institute of Experimental Hematology, Hannover Medical School, 30625 Hannover, Germany.; Laboratory for Vector Based Immunotherapy, Fraunhofer Institute for Cell Therapy and Immunology (IZI), 04103 Leipzig, Germany.; Department of Medicine II, University Cancer Center Leipzig (UCCL), University of Leipzig Medical Center, 04103 Leipzig, Germany., Adriouch S; University of Rouen, INSERM, U1234, Pathophysiology Autoimmunity and Immunotherapy (PANTHER), Normandie University, 76000 Rouen, France., Büning H; Institute of Experimental Hematology, Hannover Medical School, 30625 Hannover, Germany.; German Center for Infection Research (DZIF), Partner Site Hannover-Braunschweig, 38124 Braunschweig, Germany.

Publikováno v: Molecular therapy. Methods & clinical development [Mol Ther Methods Clin Dev] 2023 Aug 22; Vol. 30, pp. 576-592. Date of Electronic Publication: 2023 Aug 22 (Print Publication: 2023).

Hepatitis D virus interferes with hepatitis B virus RNA production via interferon-dependent and -independent mechanisms.

Autor: Lucifora J; CIRI, Centre International de Recherche en Infectiologie, Univ Lyon, Inserm, U1111, Université Claude Bernard Lyon 1, CNRS, UMR5308, ENS de Lyon, F-69007, Lyon, France; INSERM, U1052, Cancer Research Center of Lyon (CRCL), University of Lyon (UCBL1), CNRS UMR_5286, Centre Léon Bérard, Lyon, France. Electronic address: julie.lucifora@inserm.fr., Alfaiate D; INSERM, U1052, Cancer Research Center of Lyon (CRCL), University of Lyon (UCBL1), CNRS UMR_5286, Centre Léon Bérard, Lyon, France; Service des Maladies Infectieuses et Tropicales, Hôpital de la Croix-Rousse, Hospices Civils de Lyon, Lyon, France., Pons C; CIRI, Centre International de Recherche en Infectiologie, Univ Lyon, Inserm, U1111, Université Claude Bernard Lyon 1, CNRS, UMR5308, ENS de Lyon, F-69007, Lyon, France; INSERM, U1052, Cancer Research Center of Lyon (CRCL), University of Lyon (UCBL1), CNRS UMR_5286, Centre Léon Bérard, Lyon, France., Michelet M; INSERM, U1052, Cancer Research Center of Lyon (CRCL), University of Lyon (UCBL1), CNRS UMR_5286, Centre Léon Bérard, Lyon, France., Ramirez R; Gilead Sciences, Inc., Foster City, CA, USA., Fusil F; CIRI, Centre International de Recherche en Infectiologie, Univ Lyon, Inserm, U1111, Université Claude Bernard Lyon 1, CNRS, UMR5308, ENS de Lyon, F-69007, Lyon, France., Amirache F; CIRI, Centre International de Recherche en Infectiologie, Univ Lyon, Inserm, U1111, Université Claude Bernard Lyon 1, CNRS, UMR5308, ENS de Lyon, F-69007, Lyon, France., Rossi A; Institute of Experimental Hematology, Hannover Medical School, Hannover, Germany., Legrand AF; CIRI, Centre International de Recherche en Infectiologie, Univ Lyon, Inserm, U1111, Université Claude Bernard Lyon 1, CNRS, UMR5308, ENS de Lyon, F-69007, Lyon, France., Charles E; CIRI, Centre International de Recherche en Infectiologie, Univ Lyon, Inserm, U1111, Université Claude Bernard Lyon 1, CNRS, UMR5308, ENS de Lyon, F-69007, Lyon, France., Vegna S; INSERM, U1052, Cancer Research Center of Lyon (CRCL), University of Lyon (UCBL1), CNRS UMR_5286, Centre Léon Bérard, Lyon, France., Farhat R; INSERM, U1052, Cancer Research Center of Lyon (CRCL), University of Lyon (UCBL1), CNRS UMR_5286, Centre Léon Bérard, Lyon, France., Rivoire M; Centre Léon Bérard (CLB), INSERM, U1032, Lyon, France., Passot G; Service de chirurgie générale et Oncologique, Hôpital Lyon Sud, Hospices Civils de Lyon Et CICLY, EA3738, Université Lyon 1, France., Gadot N; INSERM, U1052, Cancer Research Center of Lyon (CRCL), University of Lyon (UCBL1), CNRS UMR_5286, Centre Léon Bérard, Lyon, France., Testoni B; INSERM, U1052, Cancer Research Center of Lyon (CRCL), University of Lyon (UCBL1), CNRS UMR_5286, Centre Léon Bérard, Lyon, France., Bach C; Université de Strasbourg, Inserm, Institut de Recherche sur les Maladies Virales et Hépatiques UMR_S1110, Strasbourg, France., Baumert TF; Université de Strasbourg, Inserm, Institut de Recherche sur les Maladies Virales et Hépatiques UMR_S1110, Strasbourg, France; Institut Hospitalo-Universitaire, Pôle Hépato-digestif, Nouvel Hôpital Civil, 67000 Strasbourg, France., Hyrina A; Gilead Sciences, Inc., Foster City, CA, USA., Beran RK; Gilead Sciences, Inc., Foster City, CA, USA., Zoulim F; INSERM, U1052, Cancer Research Center of Lyon (CRCL), University of Lyon (UCBL1), CNRS UMR_5286, Centre Léon Bérard, Lyon, France; Department of Hepatology, Croix-Rousse Hospital, Hospices Civils de Lyon, Lyon, France., Boonstra A; Department of Gastroenterology and Hepatology, Erasmus MC, University Medical Center Rotterdam, Gravendijkwal 230, Rotterdam, the Netherlands., Büning H; Institute of Experimental Hematology, Hannover Medical School, Hannover, Germany., Verrier ER; Université de Strasbourg, Inserm, Institut de Recherche sur les Maladies Virales et Hépatiques UMR_S1110, Strasbourg, France., Cosset FL; CIRI, Centre International de Recherche en Infectiologie, Univ Lyon, Inserm, U1111, Université Claude Bernard Lyon 1, CNRS, UMR5308, ENS de Lyon, F-69007, Lyon, France., Fletcher SP; Gilead Sciences, Inc., Foster City, CA, USA., Salvetti A; CIRI, Centre International de Recherche en Infectiologie, Univ Lyon, Inserm, U1111, Université Claude Bernard Lyon 1, CNRS, UMR5308, ENS de Lyon, F-69007, Lyon, France; INSERM, U1052, Cancer Research Center of Lyon (CRCL), University of Lyon (UCBL1), CNRS UMR_5286, Centre Léon Bérard, Lyon, France., Durantel D; CIRI, Centre International de Recherche en Infectiologie, Univ Lyon, Inserm, U1111, Université Claude Bernard Lyon 1, CNRS, UMR5308, ENS de Lyon, F-69007, Lyon, France; INSERM, U1052, Cancer Research Center of Lyon (CRCL), University of Lyon (UCBL1), CNRS UMR_5286, Centre Léon Bérard, Lyon, France.

Publikováno v: Journal of hepatology [J Hepatol] 2023 May; Vol. 78 (5), pp. 958-970. Date of Electronic Publication: 2023 Jan 24.