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of 2 099
pro vyhledávání: '"Luciferase reporter"'
Publikováno v:
Bone & Joint Research, Vol 13, Iss 2, Pp 52-65 (2024)
Aims: To investigate the effects of senescent osteocytes on bone homeostasis in the progress of age-related osteoporosis and explore the underlying mechanism. Methods: In a series of in vitro experiments, we used tert-Butyl hydroperoxide (TBHP) to in
Externí odkaz:
https://doaj.org/article/89a2d38515b04fb6a67d20bc4964cbed
Autor:
Yuanyuan Xu, Jianchang Xu, Sirong Chen, Anbang Zhou, Guangjing Huang, Shidao Huang, Dianbo Yu, Biaoliang Wu
Publikováno v:
BMC Medical Genomics, Vol 16, Iss 1, Pp 1-14 (2023)
Abstract Background Diabetic foot ulcers (DFU) are among the fastest-growing diseases worldwide. Recent evidence has emphasized the critical role of microRNA (miRNA)-mRNA networks in various chronic wounds, including DFU. In this study, we aimed to c
Externí odkaz:
https://doaj.org/article/8dfc5f8bd1f246b5afc2eb9117ca4656
Publikováno v:
World Journal of Surgical Oncology, Vol 21, Iss 1, Pp 1-11 (2023)
Abstract Background Long non-coding RNAs (lncRNAs) are critical regulators in the initiation and progression of breast cancer. Our study aims to characterize the functions of LINC02086 which few published in breast cancer and decipher the downstream
Externí odkaz:
https://doaj.org/article/75b4e29a4af040a4a6a79bd9ffebffc2
Autor:
Julia Tillmanns, Jintawee Kicuntod, Antonia Ehring, Endrit Elbasani, Eva Maria Borst, Debora Obergfäll, Regina Müller, Friedrich Hahn, Manfred Marschall
Publikováno v:
Pathogens, Vol 13, Iss 8, p 645 (2024)
Human cytomegalovirus (HCMV) represents a highly medically important pathogen which has constantly been the subject of both molecular and clinical investigations. HCMV infections, especially those in high-risk patients, still raise many unanswered qu
Externí odkaz:
https://doaj.org/article/6303abed90c243a794f8616fda463bb4
Autor:
Meghan V. Diefenbacher, Thomas J. Baric, David R. Martinez, Ralph S. Baric, Nicholas J. Catanzaro, Timothy P. Sheahan
Publikováno v:
Virus Research, Vol 339, Iss , Pp 199286- (2024)
The genetic diversity of the coronavirus (CoV) family poses a significant challenge for drug discovery and development. Traditional antiviral drugs often target specific viral proteins from specific viruses which limits their use, especially against
Externí odkaz:
https://doaj.org/article/f4cb635a13784784a2d1ae931b9ec45c
Publikováno v:
Journal of Integrative Agriculture, Vol 22, Iss 5, Pp 1445-1454 (2023)
MicroRNAs (miRNAs), a class of small non-coding RNAs, are crucial endogenous gene regulators in a range of animals, including plant-parasitic nematodes. Meloidogyne graminicola is an obligate sedentary endoparasite of rice and causes significant yiel
Externí odkaz:
https://doaj.org/article/d4e64c3fbc214cacb47ba85ab39292b8
Publikováno v:
Journal of Orthopaedic Surgery and Research, Vol 17, Iss 1, Pp 1-13 (2022)
Abstract Objective Osteosarcoma (OS) is more common in adolescents and significantly harmful, and the survival rate is considerably low, especially in patients with metastatic OS. The identification of effective biomarkers and associated regulatory m
Externí odkaz:
https://doaj.org/article/4ef8d399237643689d82ab5e2acf79df
Publikováno v:
Regenerative Therapy, Vol 21, Iss , Pp 342-350 (2022)
Introduction: To probe the impacts and biological roles of miR-4739/ITGA10 on the proliferation, differentiation and apoptosis of osteoblasts. Methods: Bioinformatics analysis was conducted to screen the key genes in osteoporosis. The upstream miRNAs
Externí odkaz:
https://doaj.org/article/64774651509248d6a904adfaad252697
Akademický článek
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Autor:
Dianne Marquez Lopez, Connor J. Maltby, Hannah Warming, Nullin Divecha, Mariana Vargas-Caballero, Mark J. Coldwell, Katrin Deinhardt
Publikováno v:
Frontiers in Neuroscience, Vol 17 (2023)
In Alzheimer’s disease, tau pathology is thought to spread via a prion-like manner along connected neuronal networks. For this to occur, the usually cytosolic tau protein must be secreted via an unconventional mechanism prior to uptake into the con
Externí odkaz:
https://doaj.org/article/603b8c1c08354d618dad80353d10ca98