iNOS promotes hypothalamic insulin resistance associated with deregulation of energy balance and obesity in rodents

Autor: Carlos Kiyoshi Katashima, Vagner Ramon Rodrigues Silva, Luciene Lenhare, Rodrigo Miguel Marin, José Barreto Campello Carvalheira

Publikováno v: Scientific Reports, Vol 7, Iss 1, Pp 1-11 (2017)

Abstract Inducible nitric oxide (iNOS)-mediated S-nitrosation of the metabolic signaling pathway has emerged as a post-translational modification that triggers insulin resistance in obesity and aging. However, the effects of S-nitrosation in controll

Externí odkaz: https://doaj.org/article/c3aa083aeca14bd2aebfe2399c96cba1

TGF‐β1 downregulation in the hypothalamus of obese mice through acute exercise

Autor: Licio A. Velloso, Vagner R. R. Silva, Alexandre M-Assis, Adelino Sanchez Ramos da Silva, Carlos K Katashima, Luciene Lenhare, Eduardo R. Ropelle, Leandro Pereira de Moura, Rodrigo S. Gaspar, Dennys E. Cintra, Joseane Morari, José Rodrigo Pauli

Publikováno v: Journal of Cellular Biochemistry. 120:18186-18192

Obesity and aging lead to abnormal transforming growth factor-β1 (TGF-β1) signaling in the hypothalamus, triggering the imbalance on glucose metabolism and energy homeostasis. Here, we determine the effect of acute exercise on TGF-β1 expression in

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::370c034f172091e1bc9dcecd5c766b1b
https://doi.org/10.1002/jcb.29124

High-intensity exercise training induces mitonuclear imbalance and activates the mitochondrial unfolded protein response in the skeletal muscle of aged mice

Autor: Barbara M. Crisol, Guilherme Francisco Peruca, Carlos K Katashima, Luciene Lenhare, Dennys E. Cintra, Fernando Moreira Simabuco, Adelino Sanchez Ramos da Silva, José Rodrigo Pauli, Leandro Pereira de Moura, Eduardo R. Ropelle, Chadi Pellegrini Anaruma, André V. Cordeiro, Vagner R. R. Silva, Renata R. Braga, Lucas Wesley Torres Barbosa, Rafael S Brícola

Publikováno v: Web of Science
Repositório Institucional da UNESP
Universidade Estadual Paulista (UNESP)
instacron:UNESP
GeroScience

Made available in DSpace on 2020-12-10T20:07:00Z (GMT). No. of bitstreams: 0 Previous issue date: 2020-07-31 Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq) Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9ee21027c6508e2d79cea6277c31398d

Exercise activates the hypothalamic S1PR1–STAT3 axis through the central action of interleukin 6 in mice

Autor: Eduardo R. Ropelle, Leandro Pereira de Moura, Licio A. Velloso, Jose Carlos de Lima-Junior, Luciene Lenhare, Dennys E. Cintra, Thayana O. Micheletti, Mario J.A. Saad, Adelino Sanchez Ramos da Silva, Juliana A. Camargo, Gabriela R. Passos, Rodrigo S. Gaspar, Vagner R. R. Silva, Carlos K. Katashima, Alexandre Moura-Assis, Joseane Morari, José Rodrigo Pauli

Publikováno v: Journal of Cellular Physiology. 233:9426-9436

Hypothalamic sphingosine-1-phosphate receptor 1 (S1PR1), the G protein-coupled receptor 1 of sphingosine-1-phosphate, has been described as a modulator in the control of energy homeostasis in rodents. However, this mechanism is still unclear. Here, w

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1391d335f2be5ad83a8cbf0501f21b77
https://doi.org/10.1002/jcp.26818

Chronic exercise reduces hypothalamic transforming growth factor-β1 in middle-aged obese mice

Autor: Mario Jose Abdalla Saad, Luciene Lenhare, Carla G. Bueno Silva, Carlos K. Katashima, Vagner R. R. Silva, Licio A. Velloso, Adelino Sanchez Ramos da Silva, Rafael Ludemann Camargo, Eduardo R. Ropelle, Joseane Morari, José Rodrigo Pauli

Publikováno v: Repositório Institucional da USP (Biblioteca Digital da Produção Intelectual)
Universidade de São Paulo (USP)
instacron:USP
Aging (Albany NY)

Obesity and aging are associated with hypothalamic inflammation, hyperphagia and abnormalities in the thermogenesis control. It has been demonstrated that the association between aging and obesity induces hypothalamic inflammation and metabolic disor

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1a568f6b223855816dc21ee317f4f025
https://doi.org/10.18632/aging.101281