Zobrazeno 1 - 10
of 123
pro vyhledávání: '"Lucien J. Cote"'
Autor:
Francesca Garretti, John Pham, Xiaobo Mao, Julian Agin-Liebes, Ted M. Dawson, Simon Mallal, Curtis McMurtrey, Chelsea Carpenter, Ellen Kanter, April Frazier, John Sidney, Myles B.C. Dillon, Elizabeth J. Phillips, Bjoern Peters, Alessandro Sette, Christopher Liong, Lucien J. Cote, Roy N. Alcalay, Daniela Weiskopf, Carla Oseroff, Cecilia S. Lindestam Arlehamn, William H. Hildebrand, David Sulzer, Valina L. Dawson
Publikováno v:
Nature. 546:656-661
Genetic studies have shown the association of Parkinson's disease with alleles of the major histocompatibility complex. Here we show that a defined set of peptides that are derived from α-synuclein, a protein aggregated in Parkinson's disease, act a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::790b8c842ae14e7efdd60780531848a4
https://doi.org/10.1038/nature22815
https://doi.org/10.1038/nature22815
Autor:
Madeleine Sharp, Maritza Arroyo, Cheryl Waters, Joseph H. Friedman, Elan D. Louis, Martha Orbe Reilly, Lucien J. Cote, Haydeh Payami, Kevin Novak, William C. Nichols, Carmen Serrano, Caroline M. Tanner, Michael W. Pauciulo, Llency Rosado, Ronald F. Pfeiffer, Blair Ford, Lorraine N. Clark, John G. Nutt, Michael Rezak, Elise Caccappolo, Ming X. Tang, Cynthia L. Comella, Karen Marder, Stuart A. Factor, Stanley Fahn, Diana Ruiz, Roy N. Alcalay, Susan B. Bressman, Helen Mejia-Santana, Martha Nance, William K. Scott, Eric Molho
Publikováno v:
Movement Disorders. 30:278-283
Background Few studies have systematically investigated the association between PARKIN genotype and psychiatric co-morbidities of Parkison's disease (PD). PARKIN-associated PD is characterized by severe nigral dopaminergic neuronal loss, a finding th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::27b9082691efa674d4437e4bd96e4e41
https://doi.org/10.1002/mds.26065
https://doi.org/10.1002/mds.26065
Autor:
Mark Groves, Vicki Shanker, Diana Ruiz, Marta San Luciano, Mali Gana Weisz, Tanya Gurevich, Nir Giladi, Karen Marder, Elan D. Louis, Anat Mirelman, Ming X. Tang, Laurie J. Ozelius, Rivka Sachdev, Naomi Lubarr, Tsvyatko Dorovski, Harini Sarva, Joan Miravite, Ernest Roos, Roberto A. Ortega, Llency Rosado, Helen Mejia Santana, Deborah Raymond, Cheryl Waters, Christina Palmese, Lucien J. Cote, Kira Yasinovsky, Andres Deik, Susan Bressman, Maayan Zalis, Lawrence Severt, Blair Ford, Oren A. Levy, Lorraine N. Clark, Matthew Swan, Jeannie Soto-Valencia, Michael W. Pauciulo, Avi Orr-Urtreger, William C. Nichols, Stanley Fahn, Pietro Mazzoni, Martha Orbe-Reilly, Ann L. Hunt, Roy N. Alcalay, Avner Thaler, Jose Cabassa, Brooke Johannes, Matthew J. Barrett, Anat Bar Shira, Rachel Saunders-Pullman
Publikováno v:
Movement Disorders. 28:1966-1971
The phenotype of Parkinson's disease (PD) in patients with and without leucine-rich repeat kinase 2 (LRRK2) G2019S mutations reportedly is similar; however, large, uniformly evaluated series are lacking. The objective of this study was to characteriz
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c539948b419e56a29514350fe3a6c738
https://doi.org/10.1002/mds.25647
https://doi.org/10.1002/mds.25647
Autor:
Elan D. Louis, Helen Mejia-Santana, Xin Ye, Howard Andrews, Karen Marder, Xinmin Liu, Stanley Fahn, Joseph H. Lee, Cheryl Waters, Lucien J. Cote, Miguel Verbitsky, Sergey Kisselev, Blair Ford, Lorraine N. Clark, Rong Cheng
Publikováno v:
Molecular Genetics & Genomic Medicine
To date, only one genome-wide study has assessed the contribution of copy number variants (CNVs) to Parkinson's disease (PD). We conducted a genome-wide scan for CNVs in a case–control dataset of Ashkenazi Jewish (AJ) origin (268 PD cases and 178 c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8c3603426908ab9cd337b7134ab069d4
https://doi.org/10.1002/mgg3.18
https://doi.org/10.1002/mgg3.18
Autor:
Roy N. Alcalay, Yian Gu, Helen Mejia-Santana, Lucien J. Cote, Karen Marder, Nikolaos Scarmeas
Publikováno v:
Movement Disorders. 27:771-774
Background: Recent studies have demonstrated an association between a Mediterranean-type diet and Alzheimer’s risk. We assessed the association between Mediterranean-type diet adherence and Parkinson’s disease (PD) status. Methods: Two hundred an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::247bf6b6ad4e92f2249b010d062f28be
https://doi.org/10.1002/mds.24918
https://doi.org/10.1002/mds.24918
Autor:
Llency Rosado, Ming X. Tang, Ruth Ottman, Kevin Novak, Lucien J. Cote, Steven J. Frucht, Laura Marsh, Brad Hiner, Danna Jennings, Caroline M. Tanner, Miguel Verbitsky, Barbara Ross, William K. Scott, Stanley Fahn, Helen Mejia-Santana, Andrew Siderowf, Susan B. Bressman, Elan D. Louis, Howard Andrews, Ronald F. Pfeiffer, Joseph H. Friedman, Brian C. Rakitin, Sergey Kisselev, Roy N. Alcalay, Elise Caccappolo, Michael Rezak, Blair Ford, Lorraine N. Clark, Cynthia L. Comella, Amy Colcher, Cheryl Waters, Karen Marder, Susan F. Mickel, Martha Nance
Publikováno v:
Journal of the International Neuropsychological Society. 17:91-100
The cognitive profile of early onset Parkinson’s disease (EOPD) has not been clearly defined. Mutations in the parkin gene are the most common genetic risk factor for EOPD and may offer information about the neuropsychological pattern of performanc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e867c384f4661459f47a33ee84fa1da7
https://doi.org/10.1017/s1355617710001190
https://doi.org/10.1017/s1355617710001190
Autor:
Lucien J. Cote, Karen Marder, Madeleine Sharp, William C. Nichols, Jean-Paul Vonsattel, Lorraine N. Clark, Roy N. Alcalay
Publikováno v:
Movement Disorders. 29:566-568
Background PARKIN -related disease remains incompletely understood. First, the pathogenicity of heterozygous PARKIN mutations is unclear though some evidence supports causality. Second, unlike sporadic Parkinson’s disease (PD), Lewy bodies are pres
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b164b81500d8904595b7f7c10c40f1ea
https://doi.org/10.1002/mds.25792
https://doi.org/10.1002/mds.25792
Autor:
Cheryl Waters, Barbara Ross, Lucien J. Cote, Karen Marder, Yuanjia Wang, Blair Ford, Lorraine N. Clark, Helen Mejia-Santana, Stanley Fahn, Elan D. Louis, Ruth Ottman, Steven J. Frucht, Juliette Harris, Howard Andrews
Publikováno v:
Neurology. 69:1270-1277
Objective: To evaluate the frequency of glucocerebrosidase ( GBA ) mutations in cases and controls enrolled in the Genetic Epidemiology of Parkinson’s Disease (GEPD) study. Methods: We sequenced all exons of the GBA gene in 278 Parkinson disease (P
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0a6b2d88a2fbe022c40d40fe9c64bd9e
https://doi.org/10.1212/01.wnl.0000276989.17578.02
https://doi.org/10.1212/01.wnl.0000276989.17578.02
Autor:
Yuanjia Wang, Stanley Fahn, Lucien J. Cote, Elan D. Louis, Blair Ford, Lorraine N. Clark, L. Saito, Howard Andrews, Juliette Harris, Cheryl Waters, Karen Marder, Ruth Ottman, E. Karlins, Steven J. Frucht, Helen Mejia-Santana
Publikováno v:
Neurology. 67:1786-1791
To evaluate the frequency of leucine-rich repeat kinase gene (LRRK2) mutations and single nucleotide polymorphisms (SNPs) in early-onset Parkinson disease (EOPD) and late-onset Parkinson disease (LOPD).We genotyped five previously reported LRRK2 muta
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f730adb75d7881203b2490e1bd5fc4d1
https://doi.org/10.1212/01.wnl.0000244345.49809.36
https://doi.org/10.1212/01.wnl.0000244345.49809.36
Publikováno v:
Neuropsychologia. 44:1962-1977
Patients with Parkinson's disease (PD), a degenerative disorder primarily affecting the nigrostriatal dopamine system, exhibit deficits in selecting task-relevant stimuli in the presence of irrelevant stimuli, such as in visual search tasks. However,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6cb96200e160cb746d5883a8edac1d80
https://doi.org/10.1016/j.neuropsychologia.2006.01.037
https://doi.org/10.1016/j.neuropsychologia.2006.01.037