Cell-free DNA profiling of metastatic prostate cancer reveals microsatellite instability, structural rearrangements and clonal hematopoiesis

Autor: Markus Mayrhofer, Bram De Laere, Tom Whitington, Peter Van Oyen, Christophe Ghysel, Jozef Ampe, Piet Ost, Wim Demey, Lucien Hoekx, Dirk Schrijvers, Barbara Brouwers, Willem Lybaert, Els Everaert, Daan De Maeseneer, Michiel Strijbos, Alain Bols, Karen Fransis, Steffi Oeyen, Pieter-Jan van Dam, Gert Van den Eynden, Annemie Rutten, Markus Aly, Tobias Nordström, Steven Van Laere, Mattias Rantalainen, Prabhakar Rajan, Lars Egevad, Anders Ullén, Jeffrey Yachnin, Luc Dirix, Henrik Grönberg, Johan Lindberg

Publikováno v: Genome Medicine, Vol 10, Iss 1, Pp 1-13 (2018)

Abstract Background There are multiple existing and emerging therapeutic avenues for metastatic prostate cancer, with a common denominator, which is the need for predictive biomarkers. Circulating tumor DNA (ctDNA) has the potential to cost-efficient

Externí odkaz: https://doaj.org/article/4783b889dd4d4c3c8abf60a59cf0a086

Intravascular double J stent migration: A case report, review, and management algorithm

Autor: Stefan De Wachter, Donald Vaganée, Sam Tilborghs, Lucien Hoekx

Publikováno v: Urology Annals
Urology Annals, Vol 11, Iss 1, Pp 93-97 (2019)

A double J stent (DJS) is the main therapy for ureteral obstruction when conservative treatment fails. Antegrade migration in the bladder u or retrograde migration in the ureter u are well-known complications. We present a case with intravascular mig

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4a35b56e9c3f63e2896085d08e040e14
http://europepmc.org/articles/PMC6362790

Effects of a six-month supervised physical exercise program on physical and cardio-metabolic profile and quality of life in patients with prostate cancer on androgen deprivation therapy: a pilot and feasibility study

Autor: Natalia S. Zabegalina, Stefan De Wachter, Lucien Hoekx, Gaetane Stassijns, Veerle Lamotte, Michaël M E L Henderickx, Bart Segers

Publikováno v: Central European Journal of Urology
Central European journal of urology, 71(2), 234-241. Panstwowy Zaklad Wydawnictw Lekarskich

Introduction To evaluate the effect of a six-month supervised physical exercise program on the physical and cardio-metabolic profile and quality of life in patients with prostate cancer on androgen deprivation therapy. Material and methods Twenty-sev

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4898d1a2833297b4521e59ef04ac7f10
http://europepmc.org/articles/PMC6051362

TP53 outperforms other androgen receptor biomarkers to predict abiraterone or enzalutamide outcome in metastatic castration-resistant prostate cancer

Autor: Annemie Rutten, Steven Van Laere, Henrik Grönberg, Peter A. van Dam, Dirk Goossens, Daan De Maeseneer, Mattias Rantalainen, Willem Lybaert, Piet Ost, Steffi Oeyen, Jozef Ampe, Gert Van den Eynden, Jurgen Del Favero, Lien Heyrman, Michiel Strijbos, Barbara Brouwers, Anja Brouwer, Karen Fransis, Peter Van Oyen, Bram De Laere, Wim Demey, Lucien Hoekx, Stefan Sleijfer, Anders Ullén, Christophe Ghysel, Els Everaert, Prabhakar Rajan, Alain Bols, Nick Beije, Ingeborg E. de Kruijff, Jeffrey Yachnin, Markus Mayrhofer, Johan Lindberg, Valerie van Dam, Tom Whitington, Dirk Schrijvers, Luc Dirix

Publikováno v: Clinical cancer research
CLINICAL CANCER RESEARCH
Clinical Cancer Research, 25(6), 1766-1773. American Association for Cancer Research Inc.

Purpose: To infer the prognostic value of simultaneous androgen receptor (AR) and TP53 profiling in liquid biopsies from patients with metastatic castration-resistant prostate cancer (mCRPC) starting a new line of AR signaling inhibitors (ARSi). Expe

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7775cd4b741e99e3013042119f7c15c7
https://hdl.handle.net/10067/1585390151162165141

Circulating tumour cells and survival in abiraterone- and enzalutamide-treated patients with castration-resistant prostate cancer

Autor: Jozef Ampe, Christophe Ghysel, Bram De Laere, Steven Van Laere, Lucien Hoekx, Wim Demey, Piet Van Kerckhove, Daan De Maeseneer, Karen Fransis, Peter Van Oyen, Piet Ost, Willem Lybaert, Els Everaert, Michiel Strijbos, Jean Vandebroek, Alain Bols, Luc Dirix, Barbara Brouwers, Dirk Schrijvers, Gert Van den Eynden

Publikováno v: Journal of Clinical Oncology. 35:5049-5049

5049 Background: A heterogeneous landscape of patients with metastatic castration-resistant prostate cancer (mCRPC) exists in current clinical practice. We investigated the prognostic value of CTC enumeration and dynamics, in the context of second-li

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::b0f45365e5fc09e32adb373021fe1eb3
https://doi.org/10.1200/jco.2017.35.15_suppl.5049