Impact of anticoagulants, antiplatelet agents, and oral antidiabetic drugs on the risk of stroke in patients with diabetes and nonvalvular atrial fibrillation: A case-referent study

Autor: Lamiae Grimaldi, Fabrice Bonnet, Yann Hamon, Emmanuel Touzé, Lucien Abenhaim

Publikováno v: Thrombosis Update, Vol 15, Iss , Pp 100173- (2024)

Background: Type 2 diabetes mellitus (T2DM) and atrial fibrillation are risk factors for stroke. The potential preventive effects of cardiovascular and antidiabetic treatments on stroke risk in patients with these diseases remain insufficiently docum

Externí odkaz: https://doaj.org/article/da471708ccc4477caa79ed2e97c9ee2f

The 'RCT augmentation': a novel simulation method to add patient heterogeneity into phase III trials

Autor: Helene Karcher, Shuai Fu, Jie Meng, Mikkel Zöllner Ankarfeldt, Orestis Efthimiou, Mark Belger, Josep Maria Haro, Lucien Abenhaim, Clementine Nordon, on behalf of the GetReal Consortium Work Package

Publikováno v: BMC Medical Research Methodology, Vol 18, Iss 1, Pp 1-14 (2018)

Abstract Background Phase III randomized controlled trials (RCT) typically exclude certain patient subgroups, thereby potentially jeopardizing estimation of a drug’s effects when prescribed to wider populations and under routine care (“effectiven

Externí odkaz: https://doaj.org/article/476787d5e1b34f6b872ca637c030a6cc

Immune thrombocytopenia in adults: a prospective cohort study of clinical features and predictors of outcome

Autor: Lamiae Grimaldi-Bensouda, Clémentine Nordon, Marc Michel, Jean-François Viallard, Daniel Adoue, Nadine Magy-Bertrand, Jean-Marc Durand, Philippe Quittet, Olivier Fain, Bernard Bonnotte, Anne-Sophie Morin, Nathalie Morel, Nathalie Costedoat-Chalumeau, Brigitte Pan-Petesch, Mehdi Khellaf, Antoinette Perlat, Karim Sacre, François Lefrere, Lucien Abenhaim, Bertrand Godeau

Publikováno v: Haematologica, Vol 101, Iss 9 (2016)

This prospective observational cohort study aimed to explore the clinical features of incident immune thrombocytopenia in adults and predictors of outcome, while determining if a family history of autoimmune disorder is a risk factor for immune throm

Externí odkaz: https://doaj.org/article/b08932410fa646d789be3750f7894ab7

Decongestant use and the risk of myocardial infarction and stroke: a case-crossover study

Autor: Yann Hamon, Yves Cottin, Nicolas Morisot, Clementine Nordon, Olivia Dialla, Bernard Bégaud, Emmanuel Touzé, Lucien Abenhaim, Elie Serrano, Jacques Benichou, Lamiae Grimaldi-Bensouda

Publikováno v: Scientific Reports
Scientific Reports, Nature Publishing Group, 2021, 11 (1), pp.4160. ⟨10.1038/s41598-021-83718-8⟩
Scientific Reports, Vol 11, Iss 1, Pp 1-8 (2021)

Pharmacovigilance reports of cerebral and cardiovascular events in those who use decongestants have triggered alerts related to their use. We aimed to assess the risk of stroke and myocardial infarction (MI) associated with the use of decongestants.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4b982fae81e9fe8f0108ec2a54bb6979
https://doi.org/10.1038/s41598-021-83718-8

Schizophr Res

Autor: Thomas Bovagnet, Hélène Verdoux, Josep Maria Haro, H Karcher, Javier Jimenez, Robert Olivares, Helene Chevrou-Severac, Lucien Abenhaim, Clementine Nordon, Mark Belger

Publikováno v: Schizophrenia Research
Schizophrenia Research, Elsevier, 2018, 193, pp.146-153. ⟨10.1016/j.schres.2017.07.031⟩

Objectives To explore the impact upon estimation of drug effect as a result of applying exclusion criteria in randomized-controlled trials (RCT) measuring the efficacy of antipsychotics (AP) in schizophrenia. Methods Three characteristics which may a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::409df326d0968d847bcaf05f5e8bc49c
https://doi.org/10.1016/j.schres.2017.07.031