Výsledky vyhledávání - "Lucie-Anne Voyer"

Supplementary Figure 3 from eIF4E/4E-BP Ratio Predicts the Efficacy of mTOR Targeted Therapies

Autor: Nahum Sonenberg, Ivan Topisirovic, Yi Liu, Valentina Gandin, Lucie-Anne Voyer, Peter Metrakos, Victoria Marcus, Domenick Zammit, Mamatha Bhat, Nadeem Siddiqui, Akiko Yanagiya, Bruno D. Fonseca, Masahiro Morita, Tommy Alain

PDF file - 2.9MB, Figure S3 contains data that show that cells with elevated eIF4E expression exhibit resistance to asTORi. These data complement the main figures of the manuscript

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::741df993bd8ce1f83833e7b51c6479ad
https://doi.org/10.1158/0008-5472.22395990

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Supplementary Figure 2 from eIF4E/4E-BP Ratio Predicts the Efficacy of mTOR Targeted Therapies

PDF file - 2.7MB, Figure S2 contains data that show that cells with reduced levels of 4E-BP1/2 have increased resistance to the anti-neoplastic effects of PP242.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::089ebd7523754d0e243b489c1e8fb7ec
https://doi.org/10.1158/0008-5472.22395993

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Supplementary Figure Legends 1-4 from eIF4E/4E-BP Ratio Predicts the Efficacy of mTOR Targeted Therapies

PDF file - 101K

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::67c1714beb66eda4194a1348d62f0bf3
https://doi.org/10.1158/0008-5472.22395981

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Supplementary Figure 4 from eIF4E/4E-BP Ratio Predicts the Efficacy of mTOR Targeted Therapies

PDF file - 2.3MB, Figure S4 contains data that show that the eIF4E/4E-BP ratio influences the antiproliferative efficacy of asTORi.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1df800fd6ec4530a5d07d5f4583a6420
https://doi.org/10.1158/0008-5472.22395987.v1

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Supplementary Figure 1 from eIF4E/4E-BP Ratio Predicts the Efficacy of mTOR Targeted Therapies

PDF file - 2.1MB, Figure S1 contains data that show that cells acquire resistance to the anti-proliferative effects of PP242 by downregulating 4E-BP1 and 2

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::90938a63dda32d0d16e43d30401ef562
https://doi.org/10.1158/0008-5472.22395996.v1

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eIF4E/4E-BP Ratio Predicts the Efficacy of mTOR Targeted Therapies

Autor: Bruno D. Fonseca, Mamatha Bhat, Nahum Sonenberg, Victoria Marcus, Masahiro Morita, Lucie Anne Voyer, Peter Metrakos, Tommy Alain, Yi Liu, Nadeem Siddiqui, Valentina Gandin, Domenick Zammit, Ivan Topisirovic, Akiko Yanagiya

Publikováno v: Cancer Research. 72:6468-6476

Active-site mTOR inhibitors (asTORi) hold great promise for targeting dysregulated mTOR signaling in cancer. Because of the multifaceted nature of mTORC1 signaling, identification of reliable biomarkers for the sensitivity of tumors to asTORi is impe

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e1fae6aa1bf3d9f85961305ca49c283c
https://doi.org/10.1158/0008-5472.can-12-2395

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