Výsledky vyhledávání - "Lucie Wohlrábová"

Reversing protonation of weakly basic drugs greatly enhances intracellular diffusion and decreases lysosomal sequestration

Autor: Debabrata Dey, Shir Marciano, Anna Poryvai, Ondřej Groborz, Lucie Wohlrábová, Tomás Slanina, Gideon Schreiber

Drug efficacy depends not only on delivery but also on intracellular diffusion, distribution and availability. Yet, more than a half of pharmaceutical drugs are weakly basic and thus, protonated and sequestered at intracellular pH. Protonation reduce

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::f368b1e01da5e32e9fd320af212571ea
https://doi.org/10.1101/2023.04.19.537456

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Chalcogen-based ratiometric reversible BODIPY redox sensors for the determination of enantioselective methionine sulfoxide reductase activity

Autor: Michal Poljak, Lucie Wohlrábová, Eduardo Palao, Jela Nociarová, Jiří Míšek, Tomáš Slanina, Petr Klán

Publikováno v: Chemical communications (Cambridge, England). 58(44)

Many serious diseases are associated with degenerative changes caused by oxidative stress triggered by elevated concentrations of reactive oxygen species (ROS) in cells. Therefore, the development of suitable probes for monitoring such processes is o

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d62c80eae9c3c97f0568bbfd0ced6845
https://pubmed.ncbi.nlm.nih.gov/35543358

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